pI: 6.2449 |
Length (AA): 409 |
MW (Da): 46116 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128703)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G79640 | putative serine/threonine protein kinase |
Arabidopsis thaliana | AT5G14720 | protein kinase family protein |
Arabidopsis thaliana | AT4G24100 | protein kinase family protein |
Arabidopsis thaliana | AT4G10730 | putative serine/threonine protein kinase |
Brugia malayi | Bm1_11845 | oxidative-stress responsive 1 |
Caenorhabditis elegans | CELE_Y59A8B.23 | Protein GCK-3, isoform B |
Dictyostelium discoideum | DDB_G0276577 | FRAY subfamily protein kinase |
Drosophila melanogaster | Dmel_CG7693 | frayed |
Echinococcus granulosus | EgrG_000971600 | STE20:SPS1 proline alanine rich protein |
Echinococcus multilocularis | EmuJ_000971600 | STE20:SPS1 proline alanine rich protein |
Giardia lamblia | GL50803_10609 | Kinase, STE STE20 |
Homo sapiens | ENSG00000198648 | serine threonine kinase 39 |
Homo sapiens | ENSG00000172939 | oxidative stress responsive 1 |
Loa Loa (eye worm) | LOAG_02968 | STE/STE20/FRAY protein kinase |
Mus musculus | ENSMUSG00000036737 | oxidative-stress responsive 1 |
Mus musculus | ENSMUSG00000027030 | serine/threonine kinase 39 |
Neospora caninum | NCLIV_046870 | STE kinase, putative |
Oryza sativa | 4331385 | Os03g0114300 |
Oryza sativa | 4330977 | Os02g0791700 |
Oryza sativa | 4349130 | Os10g0518800 |
Oryza sativa | 4341068 | Os06g0486400 |
Schistosoma japonicum | Sjp_0051030 | ko:K08835 oxidative-stress responsive protein 1, putative |
Schistosoma mansoni | Smp_131800 | protein kinase |
Schmidtea mediterranea | mk4.002113.07 | |
Schmidtea mediterranea | mk4.000073.04 | |
Schmidtea mediterranea | mk4.003321.04 | |
Schmidtea mediterranea | mk4.004405.02 | |
Schmidtea mediterranea | mk4.000073.02 | |
Schmidtea mediterranea | mk4.000073.01 | |
Schmidtea mediterranea | mk4.003321.05 | |
Toxoplasma gondii | TGME49_225960 | STE kinase |
Trichomonas vaginalis | TVAG_124180 | STE family protein kinase |
Trichomonas vaginalis | TVAG_136430 | STE family protein kinase |
Trichomonas vaginalis | TVAG_165530 | STE family protein kinase |
Trichomonas vaginalis | TVAG_123500 | STE family protein kinase |
Trichomonas vaginalis | TVAG_292810 | STE family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y59A8B.23 | Caenorhabditis elegans | sterile | wormbase |
TGME49_225960 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | serine threonine kinase 39 | Compounds | References |
Homo sapiens | oxidative stress responsive 1 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 24.9% | 329 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 26.8% | 291 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 25.3% | 293 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 25.5% | 208 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 26.2% | 294 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 25.4% | 295 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 24.3% | 305 aa | Compounds | References |