Detailed view for TVAG_337220

Basic information

TDR Targets ID: 884265
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 8.0038 | Length (AA): 126 | MW (Da): 13903 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00581   Rhodanese-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:1902751   GO:positive regulation of cell cycle G2/M phase transition  

GO:0005622   intracellular  
GO:0004725   protein tyrosine phosphatase activity  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131881)

Species Accession Gene Product
Arabidopsis thaliana AT5G03455   dual specificity phosphatase Cdc25
Candida albicans CaO19.11662   similar to S. cerevisiae YGR203W putative CDC25-like phosphatase
Candida albicans CaO19.4185   similar to S. cerevisiae YGR203W putative CDC25-like phosphatase
Entamoeba histolytica EHI_072020   hypothetical protein
Giardia lamblia GL50803_4369   Dual specificity phosphatase Cdc25, putative
Leishmania braziliensis LbrM.32.2980   hypothetical protein, conserved
Leishmania donovani LdBPK_322880.1   As/Sb Reductase
Leishmania infantum LinJ.32.2880   As/Sb Reductase, putative;with=GeneDB:LmjF32.2740
Leishmania major LmjF.32.2740   As/Sb Reductase
Leishmania mexicana LmxM.31.2740   hypothetical protein, conserved
Oryza sativa 4331335   Os03g0108000
Oryza sativa 4349283   Os10g0545700
Saccharomyces cerevisiae YGR203W   Ych1p
Trypanosoma cruzi TcCLB.511543.20   As/Sb Reductase, putative
Trypanosoma cruzi TcCLB.508707.20   As/Sb Reductase, putative
Trichomonas vaginalis TVAG_337220   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0005 0.3625 0.3625

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_337220 (Trichomonas vaginalis), conserved hypothetical protein
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