Detailed view for TVAG_371920

Basic information

TDR Targets ID: 885744
Trichomonas vaginalis, TKL family protein kinase
Source Database / ID: 

pI: 5.843 | Length (AA): 912 | MW (Da): 104325 | Paralog Number: 79

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128906)

Species Accession Gene Product
Trichomonas vaginalis TVAG_300120   conserved hypothetical protein
Trichomonas vaginalis TVAG_356070   conserved hypothetical protein
Trichomonas vaginalis TVAG_336340   conserved hypothetical protein
Trichomonas vaginalis TVAG_339790   conserved hypothetical protein
Trichomonas vaginalis TVAG_580310   protein phosphatase 1 regulatory inhibitor subunit 16A, putative
Trichomonas vaginalis TVAG_491650   conserved hypothetical protein
Trichomonas vaginalis TVAG_330340   conserved hypothetical protein
Trichomonas vaginalis TVAG_094280   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_004640   conserved hypothetical protein
Trichomonas vaginalis TVAG_001560   ankyrin repeat domain protein, putative
Trichomonas vaginalis TVAG_358140   conserved hypothetical protein
Trichomonas vaginalis TVAG_364130   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_404710   conserved hypothetical protein
Trichomonas vaginalis TVAG_119470   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_362950   conserved hypothetical protein
Trichomonas vaginalis TVAG_079660   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_475860   conserved hypothetical protein
Trichomonas vaginalis TVAG_495810   fetal globin-inducing factor, putative
Trichomonas vaginalis TVAG_432810   conserved hypothetical protein
Trichomonas vaginalis TVAG_394280   ankyrin, putative
Trichomonas vaginalis TVAG_396290   conserved hypothetical protein
Trichomonas vaginalis TVAG_364260   conserved hypothetical protein
Trichomonas vaginalis TVAG_472760   conserved hypothetical protein
Trichomonas vaginalis TVAG_239700   conserved hypothetical protein
Trichomonas vaginalis TVAG_387720   ankyrin repeat-rich membrane-spanning protein, putative
Trichomonas vaginalis TVAG_078320   ankyrin repeat and FYVE domain containing protein, putative
Trichomonas vaginalis TVAG_026090   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_434280   homeobox-containing protein wariai, putative
Trichomonas vaginalis TVAG_102350   serine/threonine-protein kinase ripk4, putative
Trichomonas vaginalis TVAG_035020   conserved hypothetical protein
Trichomonas vaginalis TVAG_153810   conserved hypothetical protein
Trichomonas vaginalis TVAG_238810   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_076550   homeobox-containing protein wariai, putative
Trichomonas vaginalis TVAG_054080   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_280080   TKL family protein kinase
Trichomonas vaginalis TVAG_337770   ankyrin repeat and FYVE domain containing protein, putative
Trichomonas vaginalis TVAG_464490   cortactin-binding protein, putative
Trichomonas vaginalis TVAG_129000   conserved hypothetical protein
Trichomonas vaginalis TVAG_286360   conserved hypothetical protein
Trichomonas vaginalis TVAG_130140   ankyrin repeat domain, putative
Trichomonas vaginalis TVAG_254780   conserved hypothetical protein
Trichomonas vaginalis TVAG_479630   conserved hypothetical protein
Trichomonas vaginalis TVAG_071820   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_434410   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_412600   conserved hypothetical protein
Trichomonas vaginalis TVAG_262940   conserved hypothetical protein
Trichomonas vaginalis TVAG_011170   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_487730   homeobox-containing protein wariai, putative
Trichomonas vaginalis TVAG_362960   conserved hypothetical protein
Trichomonas vaginalis TVAG_491540   conserved hypothetical protein
Trichomonas vaginalis TVAG_169950   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_135130   conserved hypothetical protein
Trichomonas vaginalis TVAG_348150   TKL family protein kinase
Trichomonas vaginalis TVAG_426180   conserved hypothetical protein
Trichomonas vaginalis TVAG_087210   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_417660   cortactin-binding protein, putative
Trichomonas vaginalis TVAG_126760   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_016710   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_321770   ankyrin repeat domain protein, putative
Trichomonas vaginalis TVAG_467750   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_261230   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_194910   conserved hypothetical protein
Trichomonas vaginalis TVAG_016740   conserved hypothetical protein
Trichomonas vaginalis TVAG_378580   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_171760   nuclear factor nf-kappa-B2, putative
Trichomonas vaginalis TVAG_367480   conserved hypothetical protein
Trichomonas vaginalis TVAG_367620   conserved hypothetical protein
Trichomonas vaginalis TVAG_257580   homeobox-containing protein wariai, putative
Trichomonas vaginalis TVAG_136540   cask-interacting protein (caskin) 1,2, putative
Trichomonas vaginalis TVAG_198700   cortactin-binding protein, putative
Trichomonas vaginalis TVAG_254320   conserved hypothetical protein
Trichomonas vaginalis TVAG_487780   skeletrophin, putative
Trichomonas vaginalis TVAG_025970   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_319920   conserved hypothetical protein
Trichomonas vaginalis TVAG_107520   conserved hypothetical protein
Trichomonas vaginalis TVAG_218940   conserved hypothetical protein
Trichomonas vaginalis TVAG_245780   conserved hypothetical protein
Trichomonas vaginalis TVAG_371920   TKL family protein kinase
Trichomonas vaginalis TVAG_400750   conserved hypothetical protein
Trichomonas vaginalis TVAG_459750   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0039 0.5 0.5
0.0003 0.5 0.5
0.0016 0.5 0.5
0.0066 0.3101 0.5
0.0007 0.5 0.5
0.0033 1 1
0.0018 0.5 0.5
0.0098 0.3242 0.2373
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0042 0.5 0.5
0.0037 1 0.5
0.0063 1 1
0.0039 0.9485 0.5
0.0067 0.5 0.5
0.0062 0.6935 0.5
0.0081 1 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0007 0.5 0.5
0.0059 1 1
0.0088 0.4477 1
0.0092 1 0.5
0.0063 0.7244 0
0.0032 0.5 0.5
0.0033 0.5 0.5
0.0026 0.5 0.5
0.0061 0.6883 0.5304
0.0012 0.5 0.5
0.0036 0.5 0.5
0.0029 0.5 0.5
0.0056 1 0.5
0.0081 0.5 0.5
0.0022 0.5 0.5
0.0011 1 0.5
0.0064 0.3377 0.5
0.0027 1 0.5
0.0093 0.8828 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0069 0.3067 0.5
0.0008 0.5 0.5
0.0091 1 0.5
0.0059 1 1
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0023 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_371920 (Trichomonas vaginalis), TKL family protein kinase
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