Detailed view for TVAG_173640

Basic information

TDR Targets ID: 886351
Trichomonas vaginalis, cation-transporting ATPase, putative
Source Database / ID: 

pI: 7.4372 | Length (AA): 1206 | MW (Da): 136919 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00122   E1-E2 ATPase
PF00690   Cation transporter/ATPase, N-terminus
PF00702   haloacid dehalogenase-like hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016887   ATPase activity  
GO:0000166   nucleotide binding  
GO:0006812   cation transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127785)

Species Accession Gene Product
Arabidopsis thaliana AT5G23630   putative cation-transporting ATPase
Babesia bovis BBOV_IV002730   cation transporting ATPase, putative
Brugia malayi Bm1_38660   Probable cation-transporting ATPase C10C6.6 in chromosome IV
Candida albicans CaO19.7701   potential membrane protein similar to S. cerevisiae SPF1 (YEL031W) ER membrane P-type ATPase involved in calcium ion homeostasis
Candida albicans CaO19.30   potential membrane protein similar to S. cerevisiae SPF1 (YEL031W) ER membrane P-type ATPase involved in calcium ion homeostasis
Caenorhabditis elegans CELE_C10C6.6   Protein CATP-8
Cryptosporidium parvum cgd6_720   unknown protein
Dictyostelium discoideum DDB_G0293004   hypothetical protein
Drosophila melanogaster Dmel_CG6230   CG6230 gene product from transcript CG6230-RA
Echinococcus granulosus EgrG_000892300   cation transporting ATPase 13A1
Entamoeba histolytica EHI_065670   cation-transporting P-typeATPase, putative
Echinococcus multilocularis EmuJ_000892300   cation transporting ATPase 13A1
Giardia lamblia GL50803_92246   Cation-transporting ATPase 2, putative
Homo sapiens ENSG00000105726   ATPase type 13A1
Leishmania braziliensis LbrM.07.1110   cation-transporting ATPase, putative
Leishmania donovani LdBPK_071210.1   cation-transporting ATPase, putative
Leishmania infantum LinJ.07.1210   cation-transporting ATPase, putative
Leishmania major LmjF.07.1050   cation-transporting ATPase, putative
Leishmania mexicana LmxM.07.1050   cation-transporting ATPase, putative
Loa Loa (eye worm) LOAG_07782   hypothetical protein
Mus musculus ENSMUSG00000031862   ATPase type 13A1
Neospora caninum NCLIV_011090   cation-transporting ATPase, putative
Oryza sativa 4338738   Os05g0402800
Oryza sativa 9271115   Os05g0402850
Plasmodium berghei PBANKA_0211900   cation transporting ATPase, putative
Plasmodium falciparum PF3D7_0727800   cation transporting ATPase, putative
Plasmodium knowlesi PKNH_0212400   cation transporting ATPase, putative
Plasmodium vivax PVX_081695   cation transporting ATPase, putative
Plasmodium yoelii PY01447   Drosophila melanogaster BcDNA.GH06032
Saccharomyces cerevisiae YEL031W   ion-transporting P-type ATPase SPF1
Schistosoma japonicum Sjp_0314450   Probable cation-transporting ATPase 13A1, putative
Schistosoma japonicum Sjp_0090140   ko:K01552 ATP13A1, ATP13A; ATPase type 13A1 [EC:3.6.3.-], putative
Schistosoma japonicum Sjp_0048540   Probable cation-transporting ATPase C10C6.6, putative
Schistosoma mansoni Smp_164540   cation-transporting atpase 13a1 (G-box binding protein)
Schmidtea mediterranea mk4.003961.03   Probable cation-transporting ATPase
Schmidtea mediterranea mk4.003961.00   Probable cation-transporting ATPase
Schmidtea mediterranea mk4.003961.02  
Schmidtea mediterranea mk4.003961.07  
Schmidtea mediterranea mk4.017977.00  
Trypanosoma brucei gambiense Tbg972.8.250   cation-transporting ATPase, putative
Trypanosoma brucei Tb927.8.650   cation-transporting ATPase, putative
Trypanosoma congolense TcIL3000_8_130   cation-transporting ATPase, putative
Trypanosoma cruzi TcCLB.509611.80   cation-transporting ATPase, putative
Toxoplasma gondii TGME49_318460   P-type ATPase of unknown pump specificity (type V) protein
Theileria parva TP03_0375   integral membrane protein, putative
Trichomonas vaginalis TVAG_173640   cation-transporting ATPase, putative
Trichomonas vaginalis TVAG_182210   cation-transporting ATPase, putative

Essentiality

TVAG_173640 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.650 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.650 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.650 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.650 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0211900 Plasmodium berghei Essential plasmo
TGME49_318460 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0479 0.3193 0.4676
0.0138 0.2631 0.1571
0.0381 0.315 0.4673
0.047 0.2501 0
0.0447 0.2551 0
0.0597 0.3103 0.4677
0.0529 0.3194 0.4676
0.0562 0.2559 0
0.0562 0.2583 0.5861
0.0489 0.2743 0.4686
0.0617 0.3582 0.5855
0.0626 0.2535 0
0.0602 0.2524 0
0.0179 0.3747 0.5887
0.0135 0.3283 0.5887
0.0504 0.3187 0.4676
0.0103 0.3548 0.4686
0.0077 0.2665 0
0.0545 0.3603 0.5859
0.0064 0.2665 0
0.0615 0.3209 0.4677
0.0021 0.2665 0
0.009 0.3151 0.2915
0.0102 0.2665 0
0.0077 0.3345 0.4686
0.0328 0.3451 0.6285
0.007 0.291 0.4951
0.0572 0.2519 0
0.068 0.4136 0.6078
0.0168 0.2665 0.4017
0.0053 0.2613 0.3194
0.0426 0.2844 0.4674
0.0131 0.2665 0
0.0502 0.2513 0
0.0047 0.2697 0.4686
0.0373 0.3775 0.5851
0.0562 0.2583 0.5861
0.0421 0.3535 0.5845
0.0513 0.3141 0.6104
0.0241 0.327 0.5887
0.0542 0.2511 0
0.0456 0.2537 0
0.0093 0.2665 0.1856
0.0069 0.2697 0.4686
0.0562 0.2559 0
0.0095 0.3033 0.2981
0.0508 0.2509 0
0.0306 0.2665 0
0.0139 0.3345 0.4686
0.0079 0.2697 0.4686
0.0328 0.3451 0.6285
0.0011 0.2665 0.3393
0.0478 0.2501 0
0.0328 0.3451 0.6285
0.0328 0.3451 0.6285
0.0184 0.2697 0.4686
0.0373 0.3775 0.5851
0.0672 0.2536 0
0.0536 0.3441 0.4676
0.04 0.3779 0.5853
0.004 0.2983 0.4686
0.0513 0.3141 0.6104
0.0537 0.2516 0
0.0478 0.2512 0
0.0562 0.2583 0.5861
0.0533 0.2818 0.4676
0.0328 0.3451 0.6285
0.082 0.344 0.468
0.0395 0.3087 0.6282
0.0563 0.2561 0
0.0079 0.2697 0.4686
0.0253 0.3282 0.4686
0.0139 0.3819 0.6206
0.0151 0.2665 0.2223
0.0533 0.2818 0.4676
0.0345 0.4063 0.6166
0.0151 0.2665 0.2223
0.0503 0.2501 0
0.0562 0.2583 0.5861
0.0614 0.3209 0.4677
0.0095 0.3033 0.2981
0.0103 0.3548 0.4686
0.0447 0.2551 0
0.0155 0.3003 0.4915
0.0056 0.2665 0.3302
0.0579 0.2573 0.4676
0.0572 0.2519 0
0.0071 0.2665 0
0.0131 0.2665 0
0.0309 0.3779 0.5887
0.0463 0.2502 0
0.0632 0.3968 0.619
0.0508 0.2509 0
0.0421 0.3535 0.5845
0.026 0.2617 0.616
0.055 0.2515 0
0.0653 0.3216 0.4677
0.0328 0.3451 0.6285
0.0065 0.2665 0
0.0562 0.2583 0.5861
0.0516 0.2518 0
0.0129 0.2665 0
0.0062 0.2563 0.3992

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TVAG_173640 (Trichomonas vaginalis), cation-transporting ATPase, putative
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