Detailed view for TVAG_405930

Basic information

TDR Targets ID: 886739
Trichomonas vaginalis, AGC family protein kinase
Source Database / ID: 

pI: 4.5393 | Length (AA): 740 | MW (Da): 82883 | Paralog Number: 13

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127530)

Species Accession Gene Product
Arabidopsis thaliana AT1G48490   putative protein kinase
Arabidopsis thaliana AT5G62310   putative serine/threonine protein kinase IRE
Arabidopsis thaliana AT1G45160   protein kinase
Arabidopsis thaliana AT3G17850   protein kinase family protein
Brugia malayi Bm1_57280   KIAA0303
Caenorhabditis elegans CELE_C10C6.1   Protein KIN-4, isoform B
Dictyostelium discoideum DDB_G0272282   MAST family protein kinase
Drosophila melanogaster Dmel_CG6498   CG6498 gene product from transcript CG6498-RB
Echinococcus granulosus EgrG_000454700   Microtubule-associated serine/threonine-protein kinase
Entamoeba histolytica EHI_006750   protein kinase, putative
Entamoeba histolytica EHI_193290   hypothetical protein
Echinococcus multilocularis EmuJ_000712200   serine:threonine protein kinase greatwall
Echinococcus multilocularis EmuJ_000454700   microtubule associated serine:threonine protein
Homo sapiens ENSG00000105613   microtubule associated serine/threonine kinase 1
Homo sapiens ENSG00000069020   microtubule associated serine/threonine kinase family member 4
Homo sapiens ENSG00000099308   microtubule associated serine/threonine kinase 3
Homo sapiens ENSG00000086015   microtubule associated serine/threonine kinase 2
Loa Loa (eye worm) LOAG_07481   AGC/MAST/MAST protein kinase
Mus musculus ENSMUSG00000031833   microtubule associated serine/threonine kinase 3
Mus musculus ENSMUSG00000053693   microtubule associated serine/threonine kinase 1
Mus musculus ENSMUSG00000003810   microtubule associated serine/threonine kinase 2
Mus musculus ENSMUSG00000034751   microtubule associated serine/threonine kinase family member 4
Oryza sativa 4333889   Os03g0711800
Oryza sativa 4352821   Os12g0621500
Schistosoma mansoni Smp_174820   serine/threonine protein kinase
Schmidtea mediterranea mk4.000282.03  
Schmidtea mediterranea mk4.000085.04  
Schmidtea mediterranea mk4.002603.00  
Schmidtea mediterranea mk4.002041.01  
Trichomonas vaginalis TVAG_479710   AGC family protein kinase
Trichomonas vaginalis TVAG_312180   AGC family protein kinase
Trichomonas vaginalis TVAG_347430   AGC family protein kinase
Trichomonas vaginalis TVAG_030400   AGC family protein kinase
Trichomonas vaginalis TVAG_587270   serine/threonine-protein kinase, putative
Trichomonas vaginalis TVAG_011160   AGC family protein kinase
Trichomonas vaginalis TVAG_470980   AGC family protein kinase
Trichomonas vaginalis TVAG_359020   AGC family protein kinase
Trichomonas vaginalis TVAG_346740   AGC family protein kinase
Trichomonas vaginalis TVAG_047880   AGC family protein kinase
Trichomonas vaginalis TVAG_405930   AGC family protein kinase
Trichomonas vaginalis TVAG_504520   AGC family protein kinase
Trichomonas vaginalis TVAG_597230   AGC family protein kinase
Trichomonas vaginalis TVAG_020880   AGC family protein kinase

Essentiality

TVAG_405930 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C10C6.1 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens microtubule associated serine/threonine kinase 3 Compounds References
Homo sapiens microtubule associated serine/threonine kinase 1 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 35.8% 349 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.8% 299 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 31.8% 321 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 28.4% 296 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 27.1% 203 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 36.7% 349 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 36.4% 349 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 25.6% 308 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 28.8% 333 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 25.6% 305 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 27.6% 272 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 28.0% 300 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0039 0.9485 0.5
0.0033 1 1
0.0004 0.5 0.5
0.0059 1 1
0.0081 0.5 0.5
0.0042 0.5 0.5
0.0067 0.5 0.5
0.0039 0.5 0.5
0.0081 1 0.5
0.0066 0.3101 0.5
0.0008 0.5 0.5
0.0022 0.5 0.5
0.0036 0.5 0.5
0.0026 0.5 0.5
0.0091 1 0.5
0.0032 0.5 0.5
0.0012 0.5 0.5
0.0027 1 0.5
0.0069 0.3067 0.5
0.0063 0.7244 0
0.0039 0.5 0.5
0.0061 0.6883 0.5304
0.0003 0.5 0.5
0.0007 0.5 0.5
0.0092 1 0.5
0.0023 0.5 0.5
0.0011 1 0.5
0.0029 0.5 0.5
0.0093 0.8828 0.5
0.0018 0.5 0.5
0.0037 1 0.5
0.0062 0.6935 0.5
0.0016 0.5 0.5
0.0059 1 1
0.0032 0.5 0.5
0.0007 0.5 0.5
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0059 1 1
0.0064 0.3377 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.2373
0.0056 1 0.5
0.0088 0.4477 1
0.0063 1 1
0.0016 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TVAG_405930 (Trichomonas vaginalis), AGC family protein kinase
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