pI: 5.2095 |
Length (AA): 320 |
MW (Da): 35360 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129356)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G54390 | PAP-specific phosphatase HAL2-like protein |
Arabidopsis thaliana | AT5G63980 | bifunctional 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase |
Candida albicans | CaO19.105 | one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt |
Candida albicans | CaO19.7752 | one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt |
Candida albicans | CaO19.99 | one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt |
Candida albicans | CaO19.7746 | one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt |
Cryptosporidium hominis | Chro.20197 | CysQ protein |
Cryptosporidium parvum | cgd2_1810 | CysQ, sulfite synthesis pathway protein, putative |
Chlamydia trachomatis | CT_774 | 3'(2'),5'-bisphosphate nucleotidase CysQ |
Dictyostelium discoideum | DDB_G0268652 | 3',5'-bisphosphate nucleotidase |
Escherichia coli | b4214 | 3'(2'),5'-bisphosphate nucleotidase |
Entamoeba histolytica | EHI_193350 | 3(2),5-bisphosphate nucleotidase, putative |
Neospora caninum | NCLIV_048810 | inositol monophosphatase domain-containing protein, putative |
Oryza sativa | 4351686 | Os12g0183300 |
Oryza sativa | 4351685 | Os12g0183200 |
Oryza sativa | 4331065 | Os02g0805500 |
Saccharomyces cerevisiae | YOL064C | Met22p |
Toxoplasma gondii | TGME49_223668 | LYAR-type C2HC zinc finger protein |
Trichomonas vaginalis | TVAG_144580 | inositol monophosphatase, putative |
Trichomonas vaginalis | TVAG_275770 | diphosphonucleoside phosphohydrolase, putative |
Trichomonas vaginalis | TVAG_278540 | inositol monophosphatase, putative |
Trichomonas vaginalis | TVAG_308070 | myo inositol monophosphatase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b4214 | Escherichia coli | non-essential | goodall |
TGME49_223668 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_223668 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Bos taurus | Inositol-1(or 4)-monophosphatase 1 | 277 aa | 22.2% | 270 aa | Compounds | References |
Rattus norvegicus | Inositol monophosphatase 1 | 277 aa | 21.7% | 258 aa | Compounds | References |