Detailed view for TVAG_487370

Basic information

TDR Targets ID: 888713
Trichomonas vaginalis, TKL family protein kinase
Source Database / ID: 

pI: 7.9004 | Length (AA): 816 | MW (Da): 93375 | Paralog Number: 50

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127150)

Species Accession Gene Product
Caenorhabditis elegans CELE_T21G5.1   Protein T21G5.1
Loa Loa (eye worm) LOAG_02421   hypothetical protein
Trichomonas vaginalis TVAG_069920   TKL family protein kinase
Trichomonas vaginalis TVAG_391700   TKL family protein kinase
Trichomonas vaginalis TVAG_204700   TKL family protein kinase
Trichomonas vaginalis TVAG_375190   TKL family protein kinase
Trichomonas vaginalis TVAG_376060   TKL family protein kinase
Trichomonas vaginalis TVAG_293890   TKL family protein kinase
Trichomonas vaginalis TVAG_150000   TKL family protein kinase
Trichomonas vaginalis TVAG_364300   TKL family protein kinase
Trichomonas vaginalis TVAG_094540   TKL family protein kinase
Trichomonas vaginalis TVAG_457410   TKL family protein kinase
Trichomonas vaginalis TVAG_493660   TKL family protein kinase
Trichomonas vaginalis TVAG_072030   TKL family protein kinase
Trichomonas vaginalis TVAG_081730   TKL family protein kinase
Trichomonas vaginalis TVAG_306690   TKL family protein kinase
Trichomonas vaginalis TVAG_379230   TKL family protein kinase
Trichomonas vaginalis TVAG_466100   TKL family protein kinase
Trichomonas vaginalis TVAG_205560   TKL family protein kinase
Trichomonas vaginalis TVAG_237240   TKL family protein kinase
Trichomonas vaginalis TVAG_122590   TKL family protein kinase
Trichomonas vaginalis TVAG_335450   TKL family protein kinase
Trichomonas vaginalis TVAG_454640   TKL family protein kinase
Trichomonas vaginalis TVAG_062540   TKL family protein kinase
Trichomonas vaginalis TVAG_351460   TKL family protein kinase
Trichomonas vaginalis TVAG_295840   TKL family protein kinase
Trichomonas vaginalis TVAG_383270   TKL family protein kinase
Trichomonas vaginalis TVAG_487370   TKL family protein kinase
Trichomonas vaginalis TVAG_055920   TKL family protein kinase
Trichomonas vaginalis TVAG_214020   TKL family protein kinase
Trichomonas vaginalis TVAG_417670   TKL family protein kinase
Trichomonas vaginalis TVAG_539480   conserved hypothetical protein
Trichomonas vaginalis TVAG_228770   TKL family protein kinase
Trichomonas vaginalis TVAG_131540   TKL family protein kinase
Trichomonas vaginalis TVAG_161210   TKL family protein kinase
Trichomonas vaginalis TVAG_360070   TKL family protein kinase
Trichomonas vaginalis TVAG_012240   TKL family protein kinase
Trichomonas vaginalis TVAG_398890   TKL family protein kinase
Trichomonas vaginalis TVAG_223510   TKL family protein kinase
Trichomonas vaginalis TVAG_227130   TKL family protein kinase
Trichomonas vaginalis TVAG_397000   TKL family protein kinase
Trichomonas vaginalis TVAG_419390   TKL family protein kinase
Trichomonas vaginalis TVAG_294860   TKL family protein kinase
Trichomonas vaginalis TVAG_305410   AGC family protein kinase
Trichomonas vaginalis TVAG_034700   TKL family protein kinase
Trichomonas vaginalis TVAG_380230   conserved hypothetical protein
Trichomonas vaginalis TVAG_251550   TKL family protein kinase
Trichomonas vaginalis TVAG_058690   TKL family protein kinase
Trichomonas vaginalis TVAG_297410   TKL family protein kinase
Trichomonas vaginalis TVAG_011350   TKL family protein kinase
Trichomonas vaginalis TVAG_045930   TKL family protein kinase
Trichomonas vaginalis TVAG_247120   TKL family protein kinase
Trichomonas vaginalis TVAG_455190   TKL family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 25.9% 293 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0016 0.5 0.5
0.0059 1 1
0.0032 0.5 0.5
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0064 0.3377 0.5
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0011 1 0.5
0.0023 0.5 0.5
0.0018 0.5 0.5
0.0037 1 0.5
0.0029 0.5 0.5
0.0093 0.8828 0.5
0.0062 0.6935 0.5
0.0088 0.4477 1
0.0056 1 0.5
0.0063 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.2373
0.0067 0.5 0.5
0.0042 0.5 0.5
0.0039 0.5 0.5
0.0059 1 1
0.0081 0.5 0.5
0.0004 0.5 0.5
0.0066 0.3101 0.5
0.0081 1 0.5
0.0008 0.5 0.5
0.0036 0.5 0.5
0.0022 0.5 0.5
0.0033 1 1
0.0039 0.9485 0.5
0.0039 0.5 0.5
0.0063 0.7244 0
0.0061 0.6883 0.5304
0.0003 0.5 0.5
0.0007 0.5 0.5
0.0092 1 0.5
0.0091 1 0.5
0.0026 0.5 0.5
0.0032 0.5 0.5
0.0069 0.3067 0.5
0.0027 1 0.5
0.0012 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_487370 (Trichomonas vaginalis), TKL family protein kinase
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