pI: 4.7468 |
Length (AA): 291 |
MW (Da): 32818 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127387)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G56190 | alpha-soluble NSF attachment protein 2 |
Babesia bovis | BBOV_II005240 | SNAP protein, putative |
Brugia malayi | Bm1_52745 | NSF attachment protein |
Candida albicans | CaO19.2518 | Peripheral membrane protein. |
Candida albicans | CaO19.10054 | Peripheral membrane protein. |
Caenorhabditis elegans | CELE_D1014.3 | Protein SNAP-1 |
Cryptosporidium hominis | Chro.20087 | SNAP protein (soluble N-ethylmaleimide-sensitive factor Attachment Protein) |
Cryptosporidium parvum | cgd2_760 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0285111 | soluble NSF attachment protein alpha isoform |
Drosophila melanogaster | Dmel_CG6625 | alpha Soluble NSF attachment protein |
Echinococcus granulosus | EgrG_000906800 | N ethylmaleimide sensitive factor attachment |
Entamoeba histolytica | EHI_064680 | alpha-soluble NSF attachment protein, putative |
Echinococcus multilocularis | EmuJ_000906800 | N ethylmaleimide sensitive factor attachment |
Giardia lamblia | GL50803_17224 | Alpha-SNAP, putative |
Homo sapiens | ENSG00000105402 | N-ethylmaleimide-sensitive factor attachment protein, alpha |
Homo sapiens | ENSG00000125814 | N-ethylmaleimide-sensitive factor attachment protein, beta |
Leishmania braziliensis | LbrM.32.3140 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.20.5850 | soluble n-ethylmaleimide sensitive factor, putative |
Leishmania donovani | LdBPK_201660.1 | soluble n-ethylmaleimide sensitive factor, putative |
Leishmania donovani | LdBPK_323040.1 | SNAP protein, putative |
Leishmania infantum | LinJ.32.3040 | hypothetical protein, conserved |
Leishmania infantum | LinJ.20.1660 | soluble n-ethylmaleimide sensitive factor, putative |
Leishmania major | LmjF.20.1690 | SNAP protein, putative |
Leishmania major | LmjF.32.2890 | SNAP protein, putative |
Leishmania mexicana | LmxM.31.2890 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.20.1690 | soluble n-ethylmaleimide sensitive factor, putative |
Loa Loa (eye worm) | LOAG_00033 | NSF attachment protein |
Mus musculus | ENSMUSG00000006024 | N-ethylmaleimide sensitive fusion protein attachment protein alpha |
Mus musculus | ENSMUSG00000027438 | N-ethylmaleimide sensitive fusion protein attachment protein beta |
Neospora caninum | NCLIV_061620 | hypothetical protein |
Oryza sativa | 9271886 | Os01g0812600 |
Oryza sativa | 4345167 | Os08g0282400 |
Plasmodium berghei | PBANKA_1108600 | SNAP protein, putative |
Plasmodium falciparum | PF3D7_0509000 | SNAP protein (soluble N-ethylmaleimide-sensitive factor attachment protein), putative |
Plasmodium knowlesi | PKNH_1024600 | SNAP protein (soluble N-ethylmaleimide-sensitive factor attachment protein), putative |
Plasmodium vivax | PVX_098015 | soluble NSF attachment protein (SNAP), putative |
Plasmodium yoelii | PY04299 | beta-soluble nsf attachment protein |
Saccharomyces cerevisiae | YBL050W | Sec17p |
Schistosoma japonicum | Sjp_0200910 | Alpha-soluble NSF attachment protein, putative |
Schistosoma mansoni | Smp_060950 | soluble NSF attachment protein (SNAP) |
Schmidtea mediterranea | mk4.000693.04 | |
Schmidtea mediterranea | mk4.000693.05 | Soluble NSF attachment protein |
Trypanosoma brucei gambiense | Tbg972.11.18020 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.1.1890 | soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative |
Trypanosoma brucei | Tb927.11.16080 | Soluble NSF attachment protein, SNAP, putative |
Trypanosoma brucei | Tb927.1.3110 | soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative |
Trypanosoma congolense | TcIL3000.11.16000 | Soluble NSF attachment protein, SNAP, putative |
Trypanosoma congolense | TcIL3000_1_1490 | soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative |
Trypanosoma cruzi | TcCLB.509073.50 | Soluble NSF attachment protein, SNAP, putative |
Trypanosoma cruzi | TcCLB.506363.150 | soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative |
Trypanosoma cruzi | TcCLB.508405.90 | soluble N-ethylmaleimide sensitive factor (NSF) attachment protein, putative |
Trypanosoma cruzi | TcCLB.508707.160 | Soluble NSF attachment protein, SNAP, putative |
Toxoplasma gondii | TGME49_218760 | SNAP protein (soluble N-ethylmaleimide-sensitive factor Attachment Protein), putative |
Theileria parva | TP02_0828 | SNAP protein (soluble N-ethylmaleimide-sensitive factor Attachment Protein), putative |
Theileria parva | TP02_0829 | hypothetical protein |
Trichomonas vaginalis | TVAG_176230 | soluble nsf attacment protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.3110 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.3110 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.3110 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.3110 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_D1014.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_D1014.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_D1014.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_D1014.3 | Caenorhabditis elegans | sterile | wormbase |
YBL050W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1108600 | Plasmodium berghei | Essential | plasmo |
TGME49_218760 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.