Detailed view for TVAG_369500

Basic information

TDR Targets ID: 892509
Trichomonas vaginalis, tubulin, putative

Source Database / ID: 

pI: 4.6656 | Length (AA): 293 | MW (Da): 32119 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Pfam domains

PF00091   Tubulin/FtsZ family, GTPase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005874   microtubule  
GO:0005525   GTP binding  
GO:0003924   GTPase activity  
GO:0007017   microtubule-based process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_127652)

Species Accession Gene Product
Arabidopsis thaliana AT5G05620   tubulin gamma-2 chain
Arabidopsis thaliana AT3G61650   tubulin gamma-1 chain
Babesia bovis BBOV_IV007250   tubulin gamma chain
Brugia malayi Bm1_55245   Tubulin gamma chain
Candida albicans CaO19.8823   gamma tubulin-like protein
Candida albicans CaO19.1238   gamma tubulin-like protein
Caenorhabditis elegans CELE_F58A4.8   Protein TBG-1
Cryptosporidium hominis Chro.70228   gamma-tubulin
Cryptosporidium parvum cgd7_1980   gamma tubulin
Dictyostelium discoideum DDB_G0271738   gamma tubulin
Drosophila melanogaster Dmel_CG17566   gamma-Tubulin at 37C
Drosophila melanogaster Dmel_CG3157   gamma-Tubulin at 23C
Echinococcus granulosus EgrG_001099700   tubulin gamma 1 chain
Entamoeba histolytica EHI_008240   tubulin gamma chain
Echinococcus multilocularis EmuJ_001099700   tubulin gamma 1 chain
Giardia lamblia GL50803_114218   Gamma tubulin
Homo sapiens ENSG00000131462   tubulin, gamma 1
Homo sapiens ENSG00000037042   tubulin, gamma 2
Leishmania braziliensis LbrM.25.0840   gamma-tubulin
Leishmania donovani LdBPK_250990.1   tubulin gamma chain
Leishmania infantum LinJ.25.0990   gamma-tubulin
Leishmania major LmjF.25.0960   gamma-tubulin
Leishmania mexicana LmxM.25.0960   gamma-tubulin
Loa Loa (eye worm) LOAG_02400   tubulin gamma chain
Mus musculus ENSMUSG00000045007   tubulin, gamma 2
Mus musculus ENSMUSG00000035198   tubulin, gamma 1
Neospora caninum NCLIV_046130   Beta-tubulin, related
Oryza sativa 4337861   Os05g0156600
Plasmodium berghei PBANKA_1226600   tubulin gamma chain, putative
Plasmodium falciparum PF3D7_0803700   tubulin gamma chain
Plasmodium knowlesi PKNH_0115200   tubulin gamma chain, putative
Plasmodium vivax PVX_093560   tubulin gamma chain, putative
Plasmodium yoelii PY00808   tubulin gamma chain
Saccharomyces cerevisiae YLR212C   Tub4p
Schistosoma japonicum Sjp_0036720   ko:K10389 tubulin gamma, putative
Schistosoma mansoni Smp_034670   tubulin subunit gamma
Schmidtea mediterranea mk4.005127.01   Tubulin gamma chain
Schmidtea mediterranea mk4.005127.02   Tubulin gamma chain
Schmidtea mediterranea mk4.005127.00   Tubulin gamma chain
Schmidtea mediterranea mk4.006572.00   Tubulin gamma chain
Trypanosoma brucei gambiense Tbg972.3.550   gamma tubulin
Trypanosoma brucei Tb927.3.910   tubulin gamma chain
Trypanosoma congolense TcIL3000_0_03350   tubulin gamma chain
Trypanosoma cruzi TcCLB.511867.190   tubulin gamma chain
Theileria parva TP03_0233   tubulin gamma chain, putative
Trichomonas vaginalis TVAG_109820   tubulin gamma chain, putative
Trichomonas vaginalis TVAG_369500 this record   tubulin, putative


TVAG_369500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.910 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.910 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.910 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.910 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F58A4.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_F58A4.8 Caenorhabditis elegans sterile wormbase
YLR212C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Leishmania major gamma-tubulin Compounds References
Trypanosoma brucei tubulin gamma chain Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Tubulin 85 aa 30.9% 94 aa Compounds References

Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0321 0.3007 0.2994
0.0102 0.3953 0
0.0092 0.4079 0.4079
0.016 0.2927 0.2927
0.0085 0.3918 0
0.0502 0.2627 0.0704
0.0101 0.3552 0
0.0318 0.3037 0.303
0.0476 0.2934 0.2886


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_369500 (Trichomonas vaginalis), tubulin, putative
Title for this comment