Detailed view for TVAG_350290

Basic information

TDR Targets ID: 893729
Trichomonas vaginalis, STE family protein kinase
Source Database / ID: 

pI: 9.0078 | Length (AA): 335 | MW (Da): 38668 | Paralog Number: 55

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129424)

Species Accession Gene Product
Schmidtea mediterranea mk4.006075.03  
Schmidtea mediterranea mk4.086433.02   Cyclin-dependent kinase-like 2
Trichomonas vaginalis TVAG_008470   CAMK family protein kinase
Trichomonas vaginalis TVAG_008490   CAMK family protein kinase
Trichomonas vaginalis TVAG_162660   CAMK family protein kinase
Trichomonas vaginalis TVAG_390600   CAMK family protein kinase
Trichomonas vaginalis TVAG_374380   CAMK family protein kinase
Trichomonas vaginalis TVAG_082260   CAMK family protein kinase
Trichomonas vaginalis TVAG_350290   STE family protein kinase
Trichomonas vaginalis TVAG_015290   CAMK family protein kinase
Trichomonas vaginalis TVAG_274860   CAMK family protein kinase
Trichomonas vaginalis TVAG_359170   serine/threonine protein kinase, putative
Trichomonas vaginalis TVAG_483490   CAMK family protein kinase
Trichomonas vaginalis TVAG_008480   CAMK family protein kinase
Trichomonas vaginalis TVAG_125740   CAMK family protein kinase
Trichomonas vaginalis TVAG_204910   CAMK family protein kinase
Trichomonas vaginalis TVAG_140750   CAMK family protein kinase
Trichomonas vaginalis TVAG_094980   CAMK family protein kinase
Trichomonas vaginalis TVAG_440890   CAMK family protein kinase
Trichomonas vaginalis TVAG_248790   AGC family protein kinase
Trichomonas vaginalis TVAG_125390   CAMK family protein kinase
Trichomonas vaginalis TVAG_236710   CAMK family protein kinase
Trichomonas vaginalis TVAG_204920   CAMK family protein kinase
Trichomonas vaginalis TVAG_299540   CAMK family protein kinase
Trichomonas vaginalis TVAG_440120   CAMK family protein kinase
Trichomonas vaginalis TVAG_411680   CAMK family protein kinase
Trichomonas vaginalis TVAG_162650   CAMK family protein kinase
Trichomonas vaginalis TVAG_311640   CAMK family protein kinase
Trichomonas vaginalis TVAG_055630   CAMK family protein kinase
Trichomonas vaginalis TVAG_292830   CAMK family protein kinase
Trichomonas vaginalis TVAG_329120   CAMK family protein kinase
Trichomonas vaginalis TVAG_409590   CAMK family protein kinase
Trichomonas vaginalis TVAG_477880   CAMK family protein kinase
Trichomonas vaginalis TVAG_071810   CAMK family protein kinase
Trichomonas vaginalis TVAG_374370   CAMK family protein kinase
Trichomonas vaginalis TVAG_365220   CAMK family protein kinase
Trichomonas vaginalis TVAG_361490   CAMK family protein kinase
Trichomonas vaginalis TVAG_401680   AGC family protein kinase
Trichomonas vaginalis TVAG_254900   CAMK family protein kinase
Trichomonas vaginalis TVAG_043480   CAMK family protein kinase
Trichomonas vaginalis TVAG_094940   CAMK family protein kinase
Trichomonas vaginalis TVAG_422010   CAMK family protein kinase
Trichomonas vaginalis TVAG_315580   CAMK family protein kinase
Trichomonas vaginalis TVAG_382590   CAMK family protein kinase
Trichomonas vaginalis TVAG_263330   CAMK family protein kinase
Trichomonas vaginalis TVAG_228740   calcium/calmodulin-dependent protein kinase kinase, putative
Trichomonas vaginalis TVAG_411060   CAMK family protein kinase
Trichomonas vaginalis TVAG_267980   CAMK family protein kinase
Trichomonas vaginalis TVAG_094950   CAMK family protein kinase
Trichomonas vaginalis TVAG_322080   calcium/calmodulin-dependent protein kinase kinase, putative
Trichomonas vaginalis TVAG_280550   CAMK family protein kinase
Trichomonas vaginalis TVAG_171000   CAMK family protein kinase
Trichomonas vaginalis TVAG_146800   CAMK family protein kinase
Trichomonas vaginalis TVAG_202200   CAMK family protein kinase
Trichomonas vaginalis TVAG_425880   CAMK family protein kinase
Trichomonas vaginalis TVAG_167850   CAMK family protein kinase
Trichomonas vaginalis TVAG_440390   CAMK family protein kinase
Trichomonas vaginalis TVAG_125400   CAMK family protein kinase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Jak1 protein 210 aa 27.6% 199 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.9% 255 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 24.8% 266 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0016 0.5 0.5
0.0032 0.5 0.5
0.0059 1 1
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0064 0.3377 0.5
0.0059 1 1
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0011 1 0.5
0.0023 0.5 0.5
0.0037 1 0.5
0.0018 0.5 0.5
0.0029 0.5 0.5
0.0093 0.8828 0.5
0.0062 0.6935 0.5
0.0088 0.4477 1
0.0056 1 0.5
0.0063 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.2373
0.0042 0.5 0.5
0.0039 0.5 0.5
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0059 1 1
0.0081 0.5 0.5
0.0066 0.3101 0.5
0.0081 1 0.5
0.0008 0.5 0.5
0.0036 0.5 0.5
0.0022 0.5 0.5
0.0039 0.9485 0.5
0.0033 1 1
0.0063 0.7244 0
0.0039 0.5 0.5
0.0061 0.6883 0.5304
0.0003 0.5 0.5
0.0007 0.5 0.5
0.0092 1 0.5
0.0091 1 0.5
0.0026 0.5 0.5
0.0032 0.5 0.5
0.0069 0.3067 0.5
0.0027 1 0.5
0.0012 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_350290 (Trichomonas vaginalis), STE family protein kinase
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