Detailed view for TVAG_501610

Basic information

TDR Targets ID: 899991
Trichomonas vaginalis, glucosylceramidase, putative

Source Database / ID: 

pI: 6.1151 | Length (AA): 375 | MW (Da): 42457 | Paralog Number: 14

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02055   Glycosyl hydrolase family 30 TIM-barrel domain
PF17189   Glycosyl hydrolase family 30 beta sandwich domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004348   glucosylceramidase activity  
GO:0006665   sphingolipid metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129423)

Species Accession Gene Product
Brugia malayi Bm1_32350   O-Glycosyl hydrolase family 30 protein
Caenorhabditis elegans CELE_Y4C6B.6   Protein GBA-4
Caenorhabditis elegans CELE_F11E6.1   Protein GBA-3, isoform B
Drosophila melanogaster Dmel_CG31414   CG31414 gene product from transcript CG31414-RC
Drosophila melanogaster Dmel_CG31148   CG31148 gene product from transcript CG31148-RA
Homo sapiens ENSG00000177628   glucosidase, beta, acid
Loa Loa (eye worm) LOAG_01915   O-glycosyl hydrolase family 30 protein
Mus musculus ENSMUSG00000028048   glucosidase, beta, acid
Onchocerca volvulus OVOC3102   Glucosylceramidase homolog
Trichomonas vaginalis TVAG_605430   glucosylceramidase, putative
Trichomonas vaginalis TVAG_074640   glucosylceramidase, putative
Trichomonas vaginalis TVAG_593180   glucosylceramidase, putative
Trichomonas vaginalis TVAG_602230   glucosylceramidase, putative
Trichomonas vaginalis TVAG_506520   glucosylceramidase, putative
Trichomonas vaginalis TVAG_556910   glucosylceramidase, putative
Trichomonas vaginalis TVAG_595250   glucosylceramidase, putative
Trichomonas vaginalis TVAG_285890   glucosylceramidase, putative
Trichomonas vaginalis TVAG_518590   glucosylceramidase, putative
Trichomonas vaginalis TVAG_528780   glucosylceramidase, putative
Trichomonas vaginalis TVAG_525180   glucosylceramidase, putative
Trichomonas vaginalis TVAG_501610   glucosylceramidase, putative
Trichomonas vaginalis TVAG_508090   glucosylceramidase, putative
Trichomonas vaginalis TVAG_511530   glucosylceramidase, putative
Trichomonas vaginalis TVAG_508590   glucosylceramidase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens glucosidase, beta, acid Compounds References
Bos taurus Glucosylceramidase Compounds References
Mus musculus glucosidase, beta, acid Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0301 0.3637 1
0.0312 1 1
0.0259 1 1
0.0276 0.2915 1
0.0313 0.3183 0.9458
0.0271 0.7277 1
0.0256 0.3793 1
0.328 0.3278 0.8825
0.0262 0.6132 0.9089
0.0503 0.4919 1
0.0548 0.2618 0.6816
0.0516 0.6199 1
0.052 0.6413 1
0.0289 0.3024 1
0.2168 0.7326 1
0.2925 0.2763 0.8898
0.0262 0.317 1
0.0535 0.3083 1
0.1038 0.3017 1
0.0252 0.3649 1
0.0887 1 1
0.0267 0.342 0.5406
0.2012 1 1
0.0598 0.7301 1
0.0293 1 1
0.0448 0.5614 1
0.2367 0.2865 0.764
0.0263 0.5697 1
0.0258 0.3098 1
0.0278 0.8777 1
0.0312 0.5624 1
0.1098 0.2506 1
0.0288 0.4338 1
0.6128 0.5637 1
0.0253 0.5503 1
0.0833 0.3543 1
0.0271 0.3122 1
0.0252 0.3023 1
0.0285 0.3163 1
0.2017 0.4907 1
0.0532 0.556 1
0.0312 0.314 1
0.0271 0.5852 0.8863
0.0291 0.2886 1
0.0258 0.3135 1
0.0312 0.3609 1
0.0289 0.4016 1
0.0312 0.3255 1
0.0251 0.3455 1
0.0253 0.252 0.3324
0.026 1 1
0.0285 0.4996 0.4964
0.0507 0.2976 0.6966
0.2108 0.3583 1
0.0289 0.3791 1
0.0299 0.3427 1
0.0251 0.4754 1
0.0253 0.3061 1
0.0283 0.3275 0.9713
0.0299 1 1
0.0383 0.5333 1
0.0252 0.6003 1
0.0272 0.3141 1
0.03 0.6276 1
0.0286 0.565 1
0.0312 0.5246 1
0.0291 0.3088 1
0.025 0.2778 1
0.9233 1 1
0.0295 0.3361 1
0.0312 0.5077 1
0.0266 0.5338 1
0.0819 0.3581 1
0.0251 0.2954 1
0.0809 0.8877 1
0.0256 0.5442 1
0.086 0.4462 0.8193
0.0251 0.2609 1
0.029 0.9102 1
0.0262 0.4645 1
0.0805 0.8014 1
0.1925 0.5594 0.9609
0.0257 1 1
0.0564 0.306 0.3058
0.0312 0.5038 1
0.03 1 1
0.1034 1 1
0.0295 0.2708 1
0.0312 0.3352 1
0.0312 0.6282 1
0.0312 0.3622 0.9415
0.0251 0.6562 1
0.0269 0.3201 1
0.0254 0.8471 1
0.0513 0.611 1
0.028 1 1
0.0312 0.384 1
0.0225 0.5304 0.5281
0.1625 0.5511 1
0.0267 0.4385 1
0.0515 0.6786 0.6759
0.0312 0.3323 1
0.0254 0.2524 1
0.0312 0.3631 1
0.0277 0.9189 1
0.0312 0.3038 1
0.0312 1 1
0.0258 0.3221 0.5389
0.0549 0.6961 1
0.0279 0.3421 0.8652
0.026 0.4599 0.9007
0.0312 0.3657 1
0.0529 0.317 1
0.0454 0.3087 1
0.0312 0.4394 1
0.0251 0.7946 1
0.0253 0.3589 1
0.0806 0.3251 1
0.379 0.4876 1
0.0209 0.7 0.7939
0.025 0.3134 1
0.0312 0.687 0.9716
0.0312 0.3993 1
0.0301 0.3014 1
0.1034 1 1
0.0559 0.3146 0.7393
0.0271 0.589 1
0.1024 0.2574 1
0.0252 0.3055 1
0.0251 0.3042 0.9061
0.0312 0.3104 0.4459
0.0502 0.7387 1
0.0771 0.2754 1
0.1807 0.6288 1
0.0253 0.2511 1
0.0312 0.3149 1
0.0504 0.3118 1
0.1688 0.2771 1
0.029 0.6251 0.8767
0.0514 0.3035 1
0.0941 0.3109 0.9674
0.0299 0.3989 1
0.0267 0.3107 1
0.1376 0.4611 1
0.0261 0.2839 1
0.1315 0.3332 0.3332
0.0303 0.3033 1
0.0254 0.3444 1
0.0274 0.2542 1
0.0264 0.3004 1
0.0277 0.355 0.3423
0.0262 0.3193 1
0.0312 1 1
0.048 0.5422 1
0.0268 0.4233 0.4233
0.2876 0.7359 1
0.0533 0.2726 0.4284
0.0214 0.348 0.7653
0.052 0.3042 1
0.0829 0.2773 1
0.0262 0.4917 1
0.0312 0.3021 1
0.0262 0.3107 1
0.0836 0.7917 0.7901
0.0312 1 1
0.2696 1 1
0.0298 0.8707 0.8699
0.0312 0.5584 1
0.0313 0.7521 1
0.0787 1 1
0.048 1 1
0.0279 0.3349 1
0.0243 0.3398 0.5011
0.0312 0.5419 1
0.0281 0.7889 0.7845
0.0312 0.7011 0.9551
0.0312 0.3665 1
0.1057 0.2717 1
0.0562 0.2931 1
0.1594 0.2743 1
0.03 0.7682 1
0.0589 0.2751 1
0.0581 0.6244 1
0.3867 0.2931 1
0.0257 0.3341 0.4983
0.052 0.3077 1
0.026 0.4031 0.4998
0.026 0.2752 1
0.023 0.6255 1
0.0312 0.3677 1
0.0255 0.3091 0.5239
0.0291 0.6248 1
0.0312 1 1
0.0298 0.347 1
0.1082 0.7049 0.9483
0.0277 0.8237 1
0.1117 0.4398 0.634
0.0256 0.2776 1
0.0276 1 1
0.0256 0.3114 1
0.029 0.5884 1
0.0262 0.6276 0.8819
0.0276 0.3162 1
0.0566 0.3303 1
0.0259 0.2532 1
0.0534 0.6106 1
0.031 0.3101 1
0.1386 0.3338 1
0.0312 0.3514 1
0.0258 0.274 1
0.0274 0.3358 1
0.0293 0.2706 1
0.0266 0.3397 1
0.0256 0.7067 1
0.0252 0.2895 1
0.0261 0.2596 1
0.1575 0.9741 1
0.0516 0.3149 1
0.028 0.313 0.5523
0.0274 0.2901 1
0.1121 1 1
0.0505 0.2975 1
0.0451 0.3687 1
0.0584 0.3154 0.7398
0.027 0.3059 0.9422
0.0256 0.2873 0.4692
0.1133 0.3315 1
0.0312 0.4564 1
0.0572 0.6222 1
0.2426 0.3956 1
0.0266 0.5674 1
0.0303 0.2975 1
0.0266 0.3798 1
0.1319 0.2603 0.5978
0.0304 0.302 1
0.4495 1 1
0.0258 0.3678 1
0.0253 0.4993 1
0.0271 0.306 1
0.0295 0.9325 0.8467
0.1324 0.5186 0.8748
0.0557 0.3791 1
0.0165 0.276 1
0.0528 0.3041 1
0.0265 0.3058 0.9213
0.0273 0.4626 0.4626
0.0799 1 1
0.0249 0.6088 1
0.0579 0.6227 1
0.0262 0.2578 1
0.7473 0.5717 1
0.0254 0.4649 1
0.0293 0.6248 1
0.1065 0.5816 1
0.1125 0.7261 1
0.0763 1 1
0.0766 0.7264 1
0.0312 0.313 0.4311
0.0516 0.3106 1
0.0251 0.3101 1
0.0589 0.7134 1
0.0805 0.5152 1
0.0297 0.3532 1
0.0619 0.3161 1
0.0816 0.4643 1
0.1918 0.2502 0.8414
0.0795 0.8882 1
0.0312 0.314 0.962
0.0312 1 1
0.0855 1 1
0.0283 0.4001 1
0.0252 0.3382 1
0.2612 0.5196 1
0.0312 0.3649 1
0.1308 0.2662 0.8893
0.0232 0.2797 1
0.0187 0.2577 0.4937
0.0538 0.4435 1
0.0309 0.3585 0.8781
0.026 0.2561 1
0.2324 0.9181 1
0.0552 0.3363 0.7551
0.0258 0.2944 0.9499
0.0866 0.5306 1
0.0894636 1 1
0.057 0.3013 1
0.0312 0.3447 1
0.0281 0.2615 1
0.0252 0.3018 1
0.0252 1 1
0.0291 0.3685 0.5452
0.0263 0.3349 0.9244
0.0523 0.2935 1
0.0261 0.4377 0.4364
0.0312 1 1
0.0251 1 1
0.0255 0.2792 1
0.0833 0.2506 1
0.199 0.2692 1
0.0544 0.3665 0.4402
0.0444 0.2607 1
0.0299 0.3001 1
0.0271 1 1
0.0312 1 1
0.0519 0.5507 0.7735
0.0257 0.3155 0.9274
0.0312 1 1
0.0271 0.2589 1
0.1349 0.6298 0.9555
0.0253 0.8611 1
0.0522 0.3148 1
0.0553 0.263 1
0.0312 0.3113 1
0.0263 0.6528 1
0.0584 0.3213 1
0.0305 0.3313 1
0.0252 0.2953 0.4016
0.0252 0.3041 1
0.0287 0.6189 1
0.0251 0.4723 1
0.0275 0.454 0.454
0.0207 0.3056 1
0.0275 0.797 1
0.0513 0.338 0.3444
0.0259 0.6233 1
0.0552 0.7883 1
0.0259 0.308 1
0.1087 0.5576 1
0.0285 0.333 1
0.0259 0.3069 1
0.0312 0.5177 0.6146
0.0268 0.3541 1
0.0864 1 1
0.0517 0.2817 1
0.0277 0.532 1
0.1585 0.2742 1
0.0258 0.3118 0.5331
0.0258 1 1
0.0527 0.5166 1
0.0259 0.2812 0.9988
0.0586 1 1
0.0807 0.8288 1
0.0566 0.2614 0.9781
0.0248 0.2662 0.8721
0.0288 0.3437 0.9414
0.0312 0.3303 1
0.0312 1 1
0.0513 0.611 1
0.0312 0.3115 0.8801
0.0283 0.8876 1
0.0312 0.3609 1
0.0265 0.3585 1
0.025 0.5522 1
0.0282 0.5636 0.7832
0.0312 0.3023 1
0.0768 0.3366 1
0.0272 0.3699 1
0.0312 1 1
0.0185 0.2886 0.6601
0.0312 0.723 0.723
0.0312 0.3861 1
0.0258 0.2931 1
0.0518 0.3216 1
0.0542 0.6238 1
0.7995 1 1
0.0251 0.3649 1
0.9426 1 1
0.0312 0.3729 0.5929
0.0265 1 1
0.0312 0.3099 1
0.026 0.3199 1
0.0283 0.3153 1
0.0266 0.3033 0.9083
0.0312 0.8808 1
0.1134 0.4361 1
0.0283 0.311 0.528
0.0519 0.6036 1
0.029 0.3062 1
0.0258 0.6248 1
0.0302 0.8183 1
0.0301 0.3053 1
0.0557 0.6611 0.7653
0.0251 0.3072 1
0.1307 0.3962 1
0.0266 0.4416 1
0.0252 0.3631 1
0.0565 0.5621 1
0.0275 0.3385 1
0.0263 0.4087 0.4087
0.0252 0.3331 1
0.0291 1 1
0.0543 0.3001 1
0.1385 0.5582 0.6016
0.0249 0.3025 0.4455
0.0266 0.3219 0.9803
0.0521 0.3241 0.5472
0.0255 1 1
0.0253 0.4383 1
0.0312 0.378 1
0.0312 0.6273 1
0.2389 0.3851 1
0.0312 1 1
0.0529 0.317 1
0.0238 0.3346 1
0.027 1 1
0.0291 0.2656 1
0.0279 0.3134 1
0.1072 0.2542 1
0.1301 0.2912 1
0.0266 0.2997 0.4448
0.0268 0.3116 1
0.0282 0.4325 1
0.1315 0.2629 1
0.0312 0.6645 1
0.0312 1 1
0.0273 0.2758 1
0.0822 0.7063 0.7063
0.1073 0.2569 0.8768
0.0302 0.5565 0.5558
0.1025 0.4838 1
0.0266 0.3032 1
0.1295 0.7011 1
0.0303 0.3591 0.5201
0.028 0.2864 1
0.1637 0.5647 1
0.0542 0.3858 1
0.0279 1 1
0.6167 0.4178 1
0.0262 0.3255 1
0.0269 0.3147 1
0.0815 0.9743 1
0.0312 0.3447 1
0.0255 0.3104 1
0.1308 0.6346 1
0.0312 1 1
0.0301 0.3455 1
0.0518 0.3652 0.8796
0.1664 0.4825 1
0.0292 0.3107 1
0.0255 0.3762 1
0.1346 0.3733 1
0.0875 0.3533 0.3963
0.0312 0.4255 0.6526
0.028 0.3738 0.532
0.0269 0.707 1
0.03 0.4242 1
0.0271 0.3639 0.5391
0.0505 1 1
0.027 0.6624 1
0.052 0.312 1
0.0294 0.9333 1
0.0288 0.296 1
0.0505 0.5446 1
0.0297 0.3498 1
0.0278 0.298 1
0.0252 0.2917 0.8706
0.0262 0.3192 0.3387
0.051 1 1
0.0255 1 1
0.0263 0.6238 1
0.0561 0.3283 0.3498
0.025 0.6139 1
0.0564 1 1
0.1803 0.2656 1
0.0299 0.6612 1
0.0296 0.3938 0.5945
0.0532 0.3274 0.4603
0.0312 0.3033 1
0.0284 0.7753 1
0.0312 1 1
0.0312 1 1
0.08 0.3529 1
0.0252 0.33 0.5386
0.0272 0.3997 1
0.051 0.3683 1
0.0273 0.3364 1
0.2127 1 1
0.0537 0.3136 0.7434
0.0312 0.2808 1
0.0251 0.2939 1
0.0266 0.7939 1
0.0504 0.2979 1
0.025 0.275 1
0.0312 0.5565 1
0.1332 0.3595 1
0.1367 0.4618 1
0.0291 0.3077 1
0.0802 0.3166 1
0.0288 0.3609 0.8766
0.0251 0.5364 1
0.6443 0.5719 1
0.0848 0.5577 1
0.0249 0.3056 1
0.0312 0.3061 1
0.0284 0.381 1
0.0259 0.3384 0.8919
0.0263 1 1
0.0257 0.2747 0.5009
0.0305 0.3721 0.5691
0.0263 0.3043 0.9666
0.1282 0.5722 0.8935
0.0285 0.535 1
0.0312 0.3637 1
0.2623 0.4212 1
0.0263 0.2887 1
0.0312 0.6274 1
0.0312 1 1
0.0271 0.3389 1
0.0536 0.723 1
0.0291 0.3165 0.3592
0.0312 0.3126 0.6706
0.1437 0.269 1
0.0255 0.2644 0.9167
0.0286 0.3632 0.4534
0.027 0.6934 1
0.0536 0.3014 1
0.1366 0.3975 1
0.0871 0.3548 0.5319
0.0533 0.3381 1
0.0258 0.305 1
0.0261 0.6282 1
0.0563 0.2653 1
0.0277 1 1
0.0259 0.4844 1
0.0545 1 1
0.0312 0.6254 1
0.0269 1 1
0.0255 0.3074 1
0.0262 0.2975 1
0.0292 0.6232 1
0.1008 1 1
0.0257 1 1
0.1888 0.261 1
0.0312 1 1
0.0254 0.3049 1
0.0537 0.6558 1
0.0519 0.2694 1
0.029 0.2966 1
0.0527 0.3625 1
0.025 0.3041 1
0.0312 0.3124 1
0.0312 0.2681 1
0.1349 0.4765 1
0.0263 0.3272 1
0.1043 1 1
0.2786 0.352 1
0.0769 1 1
0.0962 0.4353 1
0.0283 0.3513 1
0.0301 0.6276 1
0.0272 0.2645 1
0.1114 0.3221 0.9387
0.1318 0.3669 1
0.0257 0.2785 1
0.0276 0.6948 1
0.1057 0.7692 1
0.0255 0.8223 1
0.0297 0.3606 0.4342
0.0513 0.4538 1
0.0312 1 1
0.055 0.3136 0.7385
0.0312 0.298 1
0.027 0.3081 0.3064
0.2167 0.8145 1
0.0312 0.3116 1
0.0259 0.276 1
0.0312 0.6961 1
0.0252 1 1
0.0312 0.3417 1
0.0581 0.6288 1
0.0257 0.3366 1
0.0312 0.301 1
0.2696 1 1
0.0271 0.2615 1
0.0312 0.6563 1
0.0265 0.5319 1
0.0256 0.2544 1
0.0261 0.2815 0.4039
0.0253 0.6232 0.7631
0.1342 0.2626 0.5405
0.0254 0.2878 1
0.0826 0.2663 0.4339
0.0284 0.5306 1
1.3464 1 1
0.0308 0.3123 0.8682
0.025 0.3008 1
0.0272 0.4629 1
0.2444 0.5206 1
0.0576 0.3239 1
0.0399 0.3818 0.6678
0.0251 0.362 0.2902
0.025 0.8746 0.8614
0.0312 0.3714 1
0.018 0.4692 0.4688
0.0286 0.2811 0.7989
0.0277 0.5638 1
0.114 0.2581 1
0.0521 0.3149 1
0.0251 0.7366 1
0.0255 0.3096 0.5365
0.0312 0.5906 1
0.1549 0.2607 1
0.0581 0.3134 0.7138
0.0266 0.3038 1
0.1642 0.6358 1
0.4497 1 1
0.0271 0.3301 1
0.0254 0.279 1
0.0509 0.5411 0.8274
0.0254 0.6811 1
0.1074 0.7826 1
0.0273 0.3197 1
0.0312 0.2899 1
0.0288 0.2812 1
0.0266 0.3668 0.4362
0.1068 0.3376 0.444
0.468 0.6344 1
0.0267 0.3111 1
0.025 0.3014 1
0.027 1 1
0.0312 0.3556 0.3646
0.0269 0.3417 1
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