Detailed view for TVAG_452590

Basic information

TDR Targets ID: 905051
Trichomonas vaginalis, beta lactamase domain, putative

Source Database / ID: 

pI: 9.2234 | Length (AA): 248 | MW (Da): 28395 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00753   Metallo-beta-lactamase superfamily

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127147)

Species Accession Gene Product
Arabidopsis thaliana AT1G53580   persulfide dioxygenase ETHE1-like protein
Brugia malayi Bm1_46955   probable glyoxalase II, 78941-80643
Brugia malayi Bm1_46960   ethe1-prov protein
Caenorhabditis elegans CELE_C33A12.7   Protein ETHE-1
Dictyostelium discoideum DDB_G0291482   beta-lactamase domain-containing protein
Drosophila melanogaster Dmel_CG30022   CG30022 gene product from transcript CG30022-RB
Escherichia coli b0927   putative metal-binding enzyme
Echinococcus granulosus EgrG_001090400   ETHE1 protein
Entamoeba histolytica EHI_068560   metallo-beta-lactamase family protein
Echinococcus multilocularis EmuJ_001090400   ETHE1 protein
Giardia lamblia GL50803_15305   Hydroxyacylglutathione hydrolase
Giardia lamblia GL50803_8913   Hydroxyacylglutathione hydrolase
Homo sapiens ENSG00000105755   ethylmalonic encephalopathy 1
Loa Loa (eye worm) LOAG_00527   hypothetical protein
Mycobacterium leprae ML0493   Possible glyoxalase II (Hydroxyacylglutathione hydrolase) (GLX II)
Mus musculus ENSMUSG00000064254   ethylmalonic encephalopathy 1
Mycobacterium tuberculosis Rv2581c   Possible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II)
Mycobacterium tuberculosis Rv2260   Conserved hypothetical protein
Mycobacterium ulcerans MUL_1291   hypothetical protein
Mycobacterium ulcerans MUL_1731   Zn-dependent glyoxylase
Oryza sativa 4326319   Os01g0667200
Schistosoma japonicum Sjp_0023140   ko:K01774 ethe1; ethylmalonic encephalopathy 1, putative
Schistosoma mansoni Smp_080670   hypothetical protein
Schistosoma mansoni Smp_165640   beta lactamase domain
Schmidtea mediterranea mk4.012437.00   Persulfide dioxygenase ETHE1, mitochondrial
Schmidtea mediterranea mk4.008670.00   Persulfide dioxygenase ETHE1, mitochondrial
Schmidtea mediterranea mk4.000253.01   Persulfide dioxygenase ETHE1, mitochondrial
Trichomonas vaginalis TVAG_233760   beta lactamase domain, putative
Trichomonas vaginalis TVAG_452590   beta lactamase domain, putative
Trichomonas vaginalis TVAG_019300   beta lactamase domain, putative
Trichomonas vaginalis TVAG_132210   beta lactamase domain, putative
Trichomonas vaginalis TVAG_411410   beta lactamase domain, putative

Essentiality

TVAG_452590 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2295 Mycobacterium tuberculosis essential nmpdr
b0927 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0282 0.3876 1
0.0333 0.487 1
0.0101 0.5 0.5
0.0051 0.5023 0.5
0.0153 1 1
0.035 0.2506 1
0.0304 0.3722 1
0.0138 0.8072 0.8072
0.0304 0.3722 1
0.0156 1 1
0.0134 0.3422 1
0.0031 0.5 0.5
0.0173 0.5058 1
0.0259 0.336 0.9004
0.0153 1 1
0.0307 0.4131 1
0.0019 0.5 0.5
0.0085 0.271 0
0.0286 1 0.5
0.024 0.347 1
0.0151 0.5 0.5
0.0404 0.2792 0.8574
0.03 0.9089 1
0.0263 0.5703 1
0.0139 0.3313 1
0.0249 0.3365 1
0.03 0.9089 1
0.0079 0.301 0
0.0183 1 1
0.0065 0.5 0.5
0.0367 0.531 0.9883
0.0033 0.5 0.5
0.0161 1 1
0.0098 0.5 0.5
0.0068 0.616 0.5
0.0224 1 1
0.0101 0.5 0.5
0.0215 0.5175 0.5175
0.0208 0.4509 0.7815
0.0141 0.5 0.5
0.0284 0.6112 1
0.0115 1 0.5
0.0088 0.4106 0.5
0.032 0.4025 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_452590 (Trichomonas vaginalis), beta lactamase domain, putative
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