Detailed view for TVAG_127310

Basic information

TDR Targets ID: 907673
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 7.4675 | Length (AA): 235 | MW (Da): 26765 | Paralog Number: 16

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02525   Flavodoxin-like fold

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130380)

Species Accession Gene Product
Escherichia coli b3351   potassium-efflux system ancillary protein for KefB, glutathione-regulated
Escherichia coli b0901   putative NAD(P)H-dependent oxidoreductase
Giardia lamblia GL50803_15004   NADPH oxidoreductase, putative
Giardia lamblia GL50803_17150   NADPH oxidoreductase, putative
Giardia lamblia GL50803_17151   NADPH oxidoreductase, putative
Homo sapiens ENSG00000124588   NAD(P)H dehydrogenase, quinone 2
Mus musculus ENSMUSG00000046949   NAD(P)H dehydrogenase, quinone 2
Trichomonas vaginalis TVAG_228030   conserved hypothetical protein
Trichomonas vaginalis TVAG_311580   NAD(P)H dehydrogenase, putative
Trichomonas vaginalis TVAG_144070   conserved hypothetical protein
Trichomonas vaginalis TVAG_478840   conserved hypothetical protein
Trichomonas vaginalis TVAG_574690   conserved hypothetical protein
Trichomonas vaginalis TVAG_502480   conserved hypothetical protein
Trichomonas vaginalis TVAG_406950   conserved hypothetical protein
Trichomonas vaginalis TVAG_445900   conserved hypothetical protein
Trichomonas vaginalis TVAG_144100   conserved hypothetical protein
Trichomonas vaginalis TVAG_009980   conserved hypothetical protein
Trichomonas vaginalis TVAG_502470   conserved hypothetical protein
Trichomonas vaginalis TVAG_407030   NAD(P)H dehydrogenase, putative
Trichomonas vaginalis TVAG_127310   conserved hypothetical protein
Trichomonas vaginalis TVAG_152110   conserved hypothetical protein
Trichomonas vaginalis TVAG_293430   conserved hypothetical protein
Trichomonas vaginalis TVAG_517010   NAD(P)H dehydrogenase, putative
Trichomonas vaginalis TVAG_465160   conserved hypothetical protein

Essentiality

TVAG_127310 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0901 Escherichia coli non-essential goodall
b3351 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NAD(P)H dehydrogenase, quinone 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0588 0.3693 0.3693
0.0156 1 1
0.0082 0.4429 1
0.0576 0.3853 0.9502
0.0149 0.4506 1
0.0835 0.288 0.687
0.1015 1 1
0.0493 0.3317 0.3317
0.1069 1 1
0.0252 1 1
0.0652 0.2579 0.2579
0.0084 0.2556 0.2556
0.1452 1 1
0.0764 0.4459 0.4968
0.0851 0.2576 0.6974
0.0328 0.3855 1
0.0094 0.2549 1
0.0105897 1 1
0.0162 1 1
0.0517 0.2582 0.2582
0.0806 1 1
0.0686 0.4513 0.4526
0.0838 1 1
0.0088 0.5427 1
0.0096 0.2644 1
0.2653 0.619 0.6189
0.0082 1 1
0.2653 0.619 0.6189
0.0263 1 1
0.1148 1 1
0.0079 0.3919 1
0.0084 0.5476 1
0.0596 1 1
0.0483 1 1
0.0183 0.4444 1
0.0818 1 1
0.0129965 1 1
0.0595 1 1
0.0426 1 1
0.0096 0.2917 1
0.1058 0.2749 0.2747
0.1058 0.2749 0.2747
0.024 0.2588 0.2586
0.0096 1 1
0.2277 1 1
0.0092 0.5048 1
0.0419 0.845 1
0.0943 0.4605 1
0.2277 1 1
0.0408 1 1
0.2277 1 1
0.0086 1 1
0.0078 1 1
0.0583 0.4747 0.4747
0.1291 0.4113 0.4113
0.0132 1 1
0.0096 1 1
0.0797 0.3379 1
0.1439 1 1
0.017 1 1
0.0241 1 1
0.0242 0.7432 1
0.0096 1 1
0.0452417 0.802393 0.914294
0.0247 1 1
0.0096 0.2563 0.2416
0.0096 1 1
0.0079 0.3919 1
0.0818 1 1
0.1271 1 1
0.0425 1 1
0.008 0.3097 1
0.0096 1 1
0.0504 0.321 0.4332
0.081 1 1
0.0747 0.3672 0.3671
0.017 1 1
0.1012 1 1
0.0158 1 1
0.2653 0.619 0.6189
0.0096 0.2922 0.2922
0.0068194 0.836054 1
0.1058 0.2749 0.2747
0.0356 0.2759 0.8961
0.1058 0.2749 0.2747
0.012 0.269 0.269
0.0738 1 1
0.0096 0.2998 1
0.0307 0.284 0.284
0.0407 1 1
0.0179 1 1
0.0928 0.4515 0.4514
0.024 0.2698 0.2666
0.137 1 1
0.0155 0.3051 1
0.0331 1 1
0.0567 0.4757 0.5864
0.1515 1 1
0.1077 1 1
0.0077 0.5017 1
0.0096 1 1
0.0096 1 1
0.0691 1 1
0.0132 1 1
0.1447 0.3583 1
0.0171 1 1
0.0947 0.2746 0.2734
0.0169 1 1
0.1297 0.9035 1
0.0134 0.269 1
0.1285 1 1
0.0663 0.362 0.8343
0.0241 0.3991 0.3957
0.049 0.5143 0.5134
0.0096 1 1
0.0082 0.5392 1
0.2653 0.619 0.6189
0.0096 1 1
0.0485 0.6096 1
0.0171 0.3458 0.3455
0.0838 1 1
0.0138 0.4548 1
0.0565 0.4479 1
0.0567 0.4757 0.5864
0.1303 1 1
0.0621 0.2628 0.2628
0.0328 0.3855 1
0.1444 1 1
0.1178 1 1
0.0096 1 1
0.0407 1 1
0.0078 0.3155 1
0.0077 0.4268 1
0.0592 0.4171 0.4986
0.085 0.372 0.372
0.0082 1 1
0.0504 0.7881 1
0.0263 1 1
0.0819 0.2702 0.2687
0.0475 0.2635 1
0.0312 0.7048 0.944
0.1148 1 1
0.0686 0.4513 0.4526
0.0077 0.4413 0.8397
0.0634 0.2657 0.2626
0.0132 1 1
0.0159 0.4417 1
0.0096 1 1
0.0988 1 1
0.0667 0.4668 0.4666
0.0379 0.3404 1
0.1037 1 1
0.0417 0.6206 1
0.1012 1 1
0.0518 0.2573 0.2551
0.0567 0.4757 0.5864
0.0266 1 1
0.0079 0.6238 1
0.0085 1 1
0.0175 1 1
0.0661 0.3697 0.3696
0.0436 1 1
0.0096 1 1
0.1533 0.6656 1
0.011014 0.265934 1
0.0078 1 1
0.0077 1 1
0.0495 0.2864 1
0.0162 1 1
0.136742 1 1
0.0085 1 1
0.0079 1 1
0.0418 1 1
0.2277 1 1
0.058 0.38 0.6296
0.0096 0.2808 0.3186
0.1303 1 1
0.0087 0.5427 1
0.0096 0.377 1
0.0096 1 1
0.0096 1 1
0.0089 0.2653 0.9125
0.0162 1 1
0.0827 0.2697 0.2686
0.0207 0.2817 0.2806
0.0652 0.2579 0.2579
0.0396 1 1
0.0778 1 1
0.0751 0.3533 0.4069
0.1529 1 1
0.0132 1 1
0.0395 0.2519 0.2512
0.0081 0.2758 0.5439
0.016 0.792 1
0.2653 0.619 0.6189
0.0096 1 1
0.0962 0.2722 0.272
0.1123 0.9701 1
0.0082 0.4429 1
0.0105897 1 1
0.2653 0.619 0.6189
0.0096 1 1
0.0583 0.413 0.356
0.0855 0.2724 0.2724
0.025 1 1
0.0586 1 1
0.0909 0.318 0.5781
0.0079 0.7096 1
0.0263 1 1
0.0838 1 1
0.0407 0.4198 0.5364
0.0086 0.5356 1
0.0716 0.8253 1
0.0083 0.8926 1
0.0748 0.5122 0.5307
0.0504 0.7881 1
0.0828 1 1
0.0339 1 1
0.0732 0.266 0.266
0.0096 0.7438 1
0.0241 0.288 0.2878
0.0087 0.3791 1
0.0238 1 1
0.0083 0.963 1
0.0091 1 1
0.0255 0.292 0.292
0.2653 0.619 0.6189
0.0943 0.4605 1
0.0164 1 1
0.0241 1 1
0.0626 0.2972 0.2972
0.0079 0.3919 1
0.0109542 0.431171 0.431171
0.0491 1 1
0.0111398 1 1
0.0943 0.4605 1
0.2277 1 1
0.2277 1 1
0.0517 1 1
0.0096 1 1
0.0314 0.3177 1
0.0087 1 1
0.1275 0.2757 0.3657
0.0763 0.3318 0.3316
0.0828 1 1
0.0646 0.264 0.2636
0.1297 0.9035 1
0.0171 0.6997 1
0.0868 0.2713 0.2713
0.0079 0.3919 1
0.0567 0.4757 0.5864
0.1157 1 1
0.0096 1 1
0.2277 1 1
0.0082 1 1
0.1461 1 1
0.0652 0.2579 0.2579
0.0077 0.5576 1
0.0085 1 1
0.0096 1 1
0.0511 1 1
0.0475 0.2635 1
0.009 0.3646 1
0.0652 0.2579 0.2579
0.0092 0.6794 1
0.0158 0.4541 0.5346
0.0356 1 1
0.0077 0.2543 0.8042
0.055 1 1
0.0079 0.3919 1
0.0567 0.4757 0.5864
0.0105898 0.290559 1
0.0245 0.7282 0.7246
0.2277 1 1
0.0299 0.2849 0.2836
0.0922 1 1
0.0249 1 1
0.0079 0.2621 1
0.0244 1 1
0.0493 0.3439 0.4042
0.0096 1 1
0.0403 1 1
0.0073 1 1
0.0495 0.4974 0.6272
0.0163 0.3935 0.6882
0.0565 0.4479 1
0.0077 1 1
0.0587 0.3921 0.3918
0.0096 1 1
0.0855 0.3679 0.3677
0.0083 1 1
0.0855 0.3679 0.3677
0.0962 0.2722 0.272
0.0154 0.3576 0.5876
0.0517 0.8683 1
0.0578 0.416 0.4824
0.0079 0.4404 1
0.0068194 0.836054 1
0.0096 1 1
0.0096 0.3555 1
0.0401 0.293 1
0.0263 0.5069 0.6935
0.0096 0.2762 0.3436
0.0081 1 1
0.1461 1 1
0.0176 0.6343 0.7799
0.0808 1 1
0.0246 0.7871 0.892
0.0257 1 1
0.0477 0.484 1
0.0485 0.6096 1
0.0096 0.2917 1
0.0402 0.2621 1
0.0068194 0.836054 1
0.024 0.2588 0.2586
0.0096 1 1
0.008 1 1
0.0513 1 1
0.0096 0.4981 1
0.0079 0.3919 1
0.0828 1 1
0.0518 0.3194 0.3193
0.0583 0.4747 0.4747
0.0132 1 1
0.0486 1 1
0.0242 0.292 1
0.0567 0.4757 0.5864
0.1019 1 1
0.0841 0.2682 0.2682
0.1117 1 1
0.0162 1 1
0.0245 0.7282 0.7246
0.0096 1 1
0.0239 0.2597 0.2804
0.1423 0.6624 1
0.0171 1 1
0.0077 0.5816 1
0.0943 0.4605 1
0.0086 1 1
0.1058 0.2749 0.2747
0.0567 0.4757 0.5864
0.0667 1 1
0.0166 1 1
0.0842 0.296 0.5537
0.0132 1 1
0.0132 1 1
0.0595 1 1
0.058 0.38 0.6296
0.0583 0.413 0.356
0.0737 0.2644 0.5928
0.0083 0.5211 1
0.0851 0.2576 0.6974
0.0897 1 1
0.0962 0.2722 0.272
0.2653 0.619 0.6189
0.0477 0.484 1
0.0953 0.6552 1
0.1279 1 1
0.0173 0.6944 1
0.0475 0.2635 1
0.008 0.2959 1
0.0475 0.2635 1
0.0096 0.4322 1
0.0843 0.3646 0.3646
0.0333 0.4027 1
0.0404 0.5762 1
0.2653 0.619 0.6189
0.0253 1 1
0.0391 1 1
0.0932 0.9514 1
0.0096 1 1
0.0094 1 1
0.0636 0.266 0.266
0.018 0.5835 1
0.0404 1 1
0.0078 1 1
0.0475 0.2635 1
0.1123 0.9701 1
0.1037 1 1
0.0325 0.3805 1
0.0489 0.7185 1
0.0325 0.3148 1
0.0096 1 1
0.0828 0.9264 1
0.009 0.3069 1
0.0082 1 1
0.0412 0.666 1
0.016 1 1
0.1148 1 1
0.2653 0.619 0.6189
0.0325 0.3148 1
0.0452417 0.802393 0.914294
0.0083 0.9065 1
0.0096 1 1
0.0663 0.362 0.8343
0.1077 1 1
0.0267 1 1
0.1294 1 1
0.0078 0.3641 1
0.0258 1 1
0.0744 0.3718 0.3718
0.2653 0.619 0.6189
0.024 0.2588 0.2586
0.033 1 1
0.0426 0.2505 0.2505
0.0268 1 1
0.0078 0.2619 0.2512
0.0345 1 1
0.0089 0.6851 1
0.0078 1 1
0.0157 0.3838 0.6663
0.0587 1 1
0.0475 0.2635 1
0.0583 0.413 0.356
0.0528 1 1
0.0164 0.3031 1
0.058 0.38 0.6296
0.0475 0.2635 1
0.0101 0.2569 0.2038
0.0602 0.2581 0.4192
0.1603 1 1
0.0096 1 1
0.0268 0.9522 1
0.0157 0.2969 0.2877
0.2653 0.619 0.6189
0.0132 1 1
0.2653 0.619 0.6189
0.0087 1 1
0.1058 0.2749 0.2747
0.0245 0.7689 1
0.1148 1 1
0.0166 0.2995 0.6266
0.0772 0.3418 0.3814
0.0733 0.2676 0.2676
0.0327 1 1
0.0078 1 1
0.0835 0.288 0.687
0.0626 0.2972 0.2972
0.0751 0.2662 0.7528
0.0087 0.4529 1
0.0419 0.3527 0.3503
0.0096 1 1
0.1447 0.3583 1
0.0078 0.3641 1
0.077 0.4827 0.4822
0.0848 0.281 0.4282
0.0246 0.7871 0.892
0.0062 0.5 0.5
0.0171 0.3458 0.3455
0.0258 0.7423 1
0.0198 0.2799 0.2799
0.0096 1 0.5
0.0129965 1 1
0.0096 1 1
0.0079 0.5722 1
0.0163 1 1
0.0156 1 1
0.0207 0.2817 0.2806
0.0256 0.2536 0.2536
0.2653 0.619 0.6189
0.0077 0.6369 1
0.118 1 1
0.0163 0.2779 0.6882
0.0084 0.4269 1
0.0158 0.4163 0.4939
0.0517 0.8683 1
0.0404 0.5762 1
0.0175 1 1
0.1461 1 1
0.0096 0.4322 1
0.0096 1 1
0.0841 0.2682 0.2682
0.0245 1 1
0.0096 0.3768 1
0.0078 0.3641 1
0.0763 0.3318 0.3316
0.0096 1 1
0.1151 1 1
0.0082 1 1
0.0105898 0.290559 1
0.1497 1 1
0.0096 1 1
0.0478 0.412 1
0.0109542 0.431171 0.431171
0.0171 1 1
0.0079 0.5144 1
0.0079 0.3484 1
0.0827 1 1
0.0096 0.2644 1
0.0163 0.4309 0.4236
0.009 0.4569 1
0.0417 1 1
0.0258 0.7826 1
0.0567 0.4757 0.5864
0.0085 1 1
0.0962 0.2722 0.272
0.2653 0.619 0.6189
0.0843 0.3646 0.3646
0.1291 0.4113 0.4113
0.0924 0.9435 1
0.0086 0.3859 1
0.0877631 1 1
0.0091 0.5452 1
0.0079 0.5655 1
0.2653 0.619 0.6189
0.074 0.4884 0.4879
0.0818 1 1
0.1167 1 1
0.1366 1 1
0.0091 1 1
0.0096 0.4337 0.7572
0.0096 1 1
0.0756 0.2682 0.2675
0.0096 0.4615 1
0.0436 1 1
0.0078 0.4258 1
0.0163 0.4309 0.4236
0.0079 0.6363 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_127310 (Trichomonas vaginalis), conserved hypothetical protein
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