Detailed view for TVAG_095240

Basic information

TDR Targets ID: 910932
Trichomonas vaginalis, 2-deoxyglucose-6-phosphate phosphatase, putative
Source Database / ID: 

pI: 5.1553 | Length (AA): 225 | MW (Da): 25465 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13419   Haloacid dehalogenase-like hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130317)

Species Accession Gene Product
Arabidopsis thaliana AT2G38740   haloacid dehalogenase-like hydrolase family protein
Candida albicans CaO19.5437   similar to S. cerevisiae RHR2 (YIL053W) and HOR2 (YER062C) DL-glycerol-3-phosphatase genes involved in response to osmotic stres
Candida albicans CaO19.12892   similar to S. cerevisiae RHR2 (YIL053W) and HOR2 (YER062C) DL-glycerol-3-phosphatase genes involved in response to osmotic stres
Escherichia coli b2293   sugar phosphatas
Entamoeba histolytica EHI_073350   HAD hydrolase, family IA, variant 3
Mycobacterium tuberculosis Rv3400   Probable hydrolase
Mycobacterium ulcerans MUL_0545   hydrolase
Mycobacterium ulcerans MUL_0908   hydrolase
Oryza sativa 4349443   Os10g0568900
Oryza sativa 4339881   Os06g0109500
Oryza sativa 4347017   Os09g0407700
Saccharomyces cerevisiae YER062C   glycerol-1-phosphatase HOR2
Saccharomyces cerevisiae YIL053W   glycerol-1-phosphatase RHR2
Trichomonas vaginalis TVAG_456730   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_095240   2-deoxyglucose-6-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_463690   2-deoxyglucose-6-phosphate phosphatase, putative

Essentiality

TVAG_095240 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3461 Mycobacterium tuberculosis non-essential nmpdr
b2293 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier TVAG_095240 (Trichomonas vaginalis), 2-deoxyglucose-6-phosphate phosphatase, putative
Title for this comment
Comment