pI: 6.4956 |
Length (AA): 218 |
MW (Da): 24443 |
Paralog Number:
6
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126886)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G60180 | uridylate kinase-like protein |
Arabidopsis thaliana | AT5G26667 | UMP-CMP kinase |
Babesia bovis | BBOV_II007680 | UMP-CMP kinase, putative |
Brugia malayi | Bm1_14420 | UMP-CMP kinase family protein |
Brugia malayi | Bm1_13790 | adenylate kinase isoenzyme 1 |
Candida albicans | CaO19.12662 | likely uridine kinase similar to S. cerevisiae URA6 (YKL024C) |
Candida albicans | CaO19.5195 | likely uridine kinase similar to S. cerevisiae URA6 (YKL024C) |
Caenorhabditis elegans | CELE_F40F8.1 | Protein F40F8.1 |
Caenorhabditis elegans | CELE_C29F7.3 | Protein C29F7.3 |
Cryptosporidium parvum | cgd1_3140 | P-loop nucleotide (UMP) kinase |
Dictyostelium discoideum | DDB_G0287495 | UMP-CMP kinase |
Drosophila melanogaster | Dmel_CG17146 | Adenylate kinase-1 |
Drosophila melanogaster | Dmel_CG6092 | CG6092 gene product from transcript CG6092-RA |
Echinococcus granulosus | EgrG_001107800 | UMP CMP kinase |
Echinococcus granulosus | EgrG_000114000 | adenylate kinase |
Entamoeba histolytica | EHI_044740 | UMP-CMP kinase, putative |
Entamoeba histolytica | EHI_143580 | UMP-CMP kinase, putative |
Echinococcus multilocularis | EmuJ_000114000 | adenylate kinase |
Echinococcus multilocularis | EmuJ_001107800 | UMP CMP kinase |
Giardia lamblia | GL50803_90402 | Adenylate kinase |
Giardia lamblia | GL50803_4849 | Adenylate kinase |
Homo sapiens | ENSG00000106992 | adenylate kinase 1 |
Homo sapiens | ENSG00000162368 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic |
Leishmania braziliensis | LbrM.04.0960 | adenylate kinase, putative |
Leishmania donovani | LdBPK_040960.1 | adenylate kinase, putative |
Leishmania infantum | LinJ.04.0960 | adenylate kinase, putative |
Leishmania major | LmjF.04.0960 | adenylate kinase, putative |
Leishmania mexicana | LmxM.04.0960 | adenylate kinase, putative |
Loa Loa (eye worm) | LOAG_08791 | UMP-CMP kinase |
Loa Loa (eye worm) | LOAG_13717 | adenylate kinase 1 |
Mus musculus | ENSMUSG00000026817 | adenylate kinase 1 |
Mus musculus | 66588 | cytidine monophosphate (UMP-CMP) kinase 1 |
Neospora caninum | NCLIV_028510 | Uridylate kinase Ura6, related |
Oryza sativa | 4330910 | Os02g0778400 |
Oryza sativa | 9267059 | Os06g0203500 |
Oryza sativa | 4343960 | Os07g0624700 |
Oryza sativa | 4339882 | Os06g0109600 |
Onchocerca volvulus | OVOC1890 | Adenylate kinase isoenzyme 1 homolog |
Plasmodium berghei | PBANKA_0202300 | UMP-CMP kinase, putative |
Plasmodium falciparum | PF3D7_0111500 | UMP-CMP kinase, putative |
Plasmodium knowlesi | PKNH_0202100 | UMP-CMP kinase, putative |
Plasmodium vivax | PVX_081230 | UMP-CMP kinase, putative |
Plasmodium yoelii | PY05596 | ump-cmp kinase |
Saccharomyces cerevisiae | YKL024C | bifunctional uridylate/adenylate kinase |
Schistosoma japonicum | Sjp_0212050 | ko:K00939 adenylate kinase [EC2.7.4.3], putative |
Schistosoma mansoni | Smp_071390 | adenylate kinase |
Schistosoma mansoni | Smp_043620 | cytidylate kinase |
Schmidtea mediterranea | mk4.014277.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.032381.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.000418.12 | |
Schmidtea mediterranea | mk4.001366.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.013859.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.007490.00 | UMP-CMP kinase |
Schmidtea mediterranea | mk4.000892.04 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.002057.01 | UMP-CMP kinase |
Schmidtea mediterranea | mk4.000459.04 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.002231.02 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.018288.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.003938.03 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.023284.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.001204.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.038042.00 | |
Schmidtea mediterranea | mk4.000051.23 | |
Schmidtea mediterranea | mk4.026582.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.004672.00 | UMP-CMP kinase |
Schmidtea mediterranea | mk4.018397.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.000037.12 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.064529.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.022072.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.001038.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.018067.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.005380.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.039209.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.004965.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.000313.05 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.039354.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.006642.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.021188.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.031525.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.038348.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.000056.08 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.002660.06 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.004240.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.001272.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.018288.01 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.027142.00 | Putative adenylate kinase |
Schmidtea mediterranea | mk4.002715.01 | UMP-CMP kinase |
Schmidtea mediterranea | mk4.001921.02 | Putative adenylate kinase |
Trypanosoma brucei gambiense | Tbg972.9.4610 | adenylate kinase, putative |
Trypanosoma brucei | Tb927.9.8450 | UMP/CMP kinase |
Trypanosoma congolense | TcIL3000_9_2920 | adenylate kinase, putative |
Trypanosoma cruzi | TcCLB.510575.180 | adenylate kinase, putative |
Trypanosoma cruzi | TcCLB.510243.50 | adenylate kinase, putative |
Toxoplasma gondii | TGME49_257740 | UMP-CMP kinase |
Theileria parva | TP02_0690 | UMP-CMP kinase, putative |
Trichomonas vaginalis | TVAG_273750 | adenylate kinase, putative |
Trichomonas vaginalis | TVAG_160390 | uridylate kinase, putative |
Trichomonas vaginalis | TVAG_179660 | adenylate kinase isoenzyme, putative |
Trichomonas vaginalis | TVAG_493000 | adenylate kinase 1, putative |
Trichomonas vaginalis | TVAG_070830 | cytidylate kinase, putative |
Trichomonas vaginalis | TVAG_130730 | adenylate kinase, putative |
Trichomonas vaginalis | TVAG_247200 | adenylate kinase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.0350 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.0350 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.0350 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.211.0350 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F40F8.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F40F8.1 | Caenorhabditis elegans | larval arrest | wormbase |
YKL024C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_257740 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.