pI: 7.7054 |
Length (AA): 966 |
MW (Da): 108671 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_130036)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G50240 | serine/threonine-protein kinase FUSED |
Caenorhabditis elegans | CELE_F32D8.1 | Protein F32D8.1 |
Dictyostelium discoideum | DDB_G0267962 | ULK family protein kinase |
Drosophila melanogaster | Dmel_CG6551 | fused |
Echinococcus granulosus | EgrG_001028900 | serine:threonine protein kinase 36 |
Echinococcus multilocularis | EmuJ_001028900 | serine:threonine protein kinase 36 |
Giardia lamblia | GL50803_17368 | Kinase, ULK |
Homo sapiens | ENSG00000163482 | serine/threonine kinase 36 |
Leishmania braziliensis | LbrM.13.0260 | mitogen-activated protein kinase kinase 2 |
Leishmania donovani | LdBPK_130280.1 | mitogen-activated protein kinase kinase 2 |
Leishmania infantum | LinJ.13.0280 | mitogen-activated protein kinase kinase 2 |
Leishmania major | LmjF.13.0440 | mitogen-activated protein kinase kinase 2 |
Leishmania mexicana | LmxM.13.0440 | mitogen-activated protein kinase kinase 2 |
Mus musculus | ENSMUSG00000033276 | serine/threonine kinase 36 |
Oryza sativa | 4352122 | Os12g0433500 |
Schistosoma japonicum | Sjp_0026310 | ko:K06228 fused,Serine/threonine protein kinase, putative |
Schistosoma mansoni | Smp_132260 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.014854.00 | |
Schmidtea mediterranea | mk4.020170.00 | Fused-like protein |
Schmidtea mediterranea | mk4.020170.01 | Serine/threonine-protein kinase 36 |
Schmidtea mediterranea | mk4.009350.00 | |
Trypanosoma brucei gambiense | Tbg972.11.5110 | protein kinase, putative,serine/threonine protein kinase, putative |
Trypanosoma brucei | Tb927.11.4470 | ULK family serine/threonine-protein kinase, putative |
Trypanosoma congolense | TcIL3000.11.4540 | serine/threonine protein kinase, putative |
Trypanosoma cruzi | TcCLB.504089.54 | ULK family serine/threonine-protein kinase, putative |
Trypanosoma cruzi | TcCLB.504001.6 | ULK family serine/threonine-protein kinase, putative |
Trichomonas vaginalis | TVAG_196800 | CAMK family protein kinase |
Trichomonas vaginalis | TVAG_368920 | CAMK family protein kinase |
Trichomonas vaginalis | TVAG_462850 | AGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.02.2050 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.2050 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.2050 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.2050 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | serine/threonine kinase 36 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 27.0% | 293 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 31.5% | 286 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 30.7% | 264 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 30.8% | 286 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 32.8% | 287 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 29.3% | 287 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 36.3% | 168 aa | Compounds | References |