Detailed view for TVAG_485110

Basic information

TDR Targets ID: 918476
Trichomonas vaginalis, development and differentiation-enhancing factor, ddef, putative
Source Database / ID: 

pI: 6.5605 | Length (AA): 670 | MW (Da): 75631 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain
PF01412   Putative GTPase activating protein for Arf
PF16746   BAR domain of APPL family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005096   GTPase activator activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127817)

Species Accession Gene Product
Arabidopsis thaliana AT1G10870   ADP-ribosylation factor GTPase-activating protein AGD4
Arabidopsis thaliana AT5G61980   ADP-ribosylation factor GTPase-activating protein AGD1
Arabidopsis thaliana AT1G60860   ADP-ribosylation factor GTPase-activating protein AGD2
Arabidopsis thaliana AT5G13300   ADP-ribosylation factor GTPase-activating protein AGD3
Brugia malayi Bm1_47060   GTP-ase activating protein for Arf containing protein
Candida albicans CaO19.3050   potential ADP ribosylation factor GTPase activating protein (ARF GAP) similar to S. cerevisiae AGE1 (YDR524C) ARF GAP with a rol
Candida albicans CaO19.10568   potential ADP ribosylation factor GTPase activating protein (ARF GAP) similar to S. cerevisiae AGE1 (YDR524C) ARF GAP with a rol
Caenorhabditis elegans CELE_Y17G7B.15   Protein CNT-1, isoform B
Dictyostelium discoideum DDB_G0275843   Arf GTPase activating protein
Dictyostelium discoideum DDB_G0279649   Arf GTPase activating protein
Dictyostelium discoideum DDB_G0276395   Arf GTPase activating protein
Drosophila melanogaster Dmel_CG6742   Centaurin beta 1A
Echinococcus granulosus EgrG_000969700   arf GAP with coiled coil ANK repeat and PH
Entamoeba histolytica EHI_152090   ARF GTPase activating protein, putative
Echinococcus multilocularis EmuJ_000969700   arf GAP with coiled coil, ANK repeat and PH
Homo sapiens ENSG00000131584   ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Homo sapiens ENSG00000114331   ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Homo sapiens ENSG00000072818   ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Loa Loa (eye worm) LOAG_08699   GTP-ase activating protein for Arf containing protein
Mus musculus ENSMUSG00000029033   ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Mus musculus ENSMUSG00000001588   ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Mus musculus ENSMUSG00000049076   ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Oryza sativa 4347541   Os09g0510700
Oryza sativa 4330061   Os02g0632500
Oryza sativa 4346168   Os08g0537600
Schistosoma japonicum Sjp_0013720   Centaurin-beta-2, putative
Schistosoma mansoni Smp_000670   CENTB5 protein
Schmidtea mediterranea mk4.000245.06   CENTB5 protein
Trichomonas vaginalis TVAG_256810   centaurin beta, putative
Trichomonas vaginalis TVAG_439740   centaurin alpha, putative
Trichomonas vaginalis TVAG_230890   centaurin/arf, putative
Trichomonas vaginalis TVAG_485110   development and differentiation-enhancing factor, ddef, putative
Trichomonas vaginalis TVAG_110580   centaurin gamma, putative

Essentiality

TVAG_485110 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y17G7B.15 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_485110 (Trichomonas vaginalis), development and differentiation-enhancing factor, ddef, putative
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