pI: 10.5962 |
Length (AA): 129 |
MW (Da): 14138 |
Paralog Number:
13
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_126572)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G59910 | histone H2B |
Arabidopsis thaliana | AT3G45980 | histone HTB9 |
Arabidopsis thaliana | AT1G07790 | histone H2B |
Arabidopsis thaliana | AT2G28720 | histone H2B |
Arabidopsis thaliana | AT3G09480 | histone H2B |
Arabidopsis thaliana | AT5G22880 | histone H2B |
Arabidopsis thaliana | AT2G37470 | histone H2B |
Arabidopsis thaliana | AT5G02570 | histone H2B |
Arabidopsis thaliana | AT3G53650 | histone H2B |
Arabidopsis thaliana | AT3G46030 | histone HTB11 |
Babesia bovis | BBOV_II001750 | histone 2B protein, putative |
Babesia bovis | BBOV_IV006840 | histone H2B.1, putative |
Brugia malayi | Bm1_20280 | Probable histone H2B 3 |
Brugia malayi | Bm1_02800 | Histone H2B 2 |
Brugia malayi | Bm1_03575 | Probable histone H2B 4 |
Brugia malayi | Bm1_02510 | histone H2B 2 |
Candida albicans | CaO19.8654 | one of two closely related histone genes similar to S. cerevisiae HTB1 (YDR224C) and HTB2 (YBL002W) histone H2B |
Candida albicans | CaO19.6925 | one of two closely related histone genes similar to S. cerevisiae HTB1 (YDR224C) and HTB2 (YBL002W) histone H2B |
Candida albicans | CaO19.14187 | one of two closely related histone genes similar to S. cerevisiae HTB1 (YDR224C) and HTB2 (YBL002W) histone H2B |
Candida albicans | CaO19.1052 | one of two closely related histone genes similar to S. cerevisiae HTB1 (YDR224C) and HTB2 (YBL002W) histone H2B |
Caenorhabditis elegans | CELE_C50F4.5 | Protein HIS-41 |
Caenorhabditis elegans | CELE_F55G1.3 | Protein HIS-62 |
Caenorhabditis elegans | CELE_F54E12.4 | Protein HIS-58 |
Caenorhabditis elegans | CELE_B0035.8 | Protein HIS-48 |
Caenorhabditis elegans | CELE_H02I12.6 | Protein HIS-66 |
Caenorhabditis elegans | CELE_K06C4.12 | Protein HIS-22 |
Caenorhabditis elegans | CELE_ZK131.9 | Protein HIS-15 |
Caenorhabditis elegans | CELE_T10C6.11 | Protein HIS-4 |
Caenorhabditis elegans | CELE_F07B7.4 | Protein HIS-52 |
Caenorhabditis elegans | CELE_F07B7.11 | Protein HIS-54 |
Caenorhabditis elegans | CELE_F35H10.11 | Protein HIS-29 |
Caenorhabditis elegans | CELE_F08G2.1 | Protein HIS-44 |
Caenorhabditis elegans | CELE_F45F2.12 | Protein HIS-8 |
Caenorhabditis elegans | CELE_ZK131.5 | Protein HIS-11 |
Caenorhabditis elegans | CELE_K06C4.4 | Protein HIS-20 |
Caenorhabditis elegans | CELE_F17E9.9 | Protein HIS-34 |
Cryptosporidium hominis | Chro.70200 | histone H2B variant 1 |
Cryptosporidium hominis | Chro.50055 | histone H2B |
Cryptosporidium parvum | cgd5_3170 | histone H2B |
Cryptosporidium parvum | cgd7_1700 | histone H2B |
Dictyostelium discoideum | DDB_G0286509 | histone H2B domain-containing protein |
Drosophila melanogaster | Dmel_CG33870 | CG33870 gene product from transcript CG33870-RA |
Drosophila melanogaster | Dmel_CG33872 | CG33872 gene product from transcript CG33872-RA |
Drosophila melanogaster | Dmel_CG33888 | CG33888 gene product from transcript CG33888-RA |
Drosophila melanogaster | Dmel_CG33904 | CG33904 gene product from transcript CG33904-RA |
Drosophila melanogaster | Dmel_CG33908 | CG33908 gene product from transcript CG33908-RA |
Drosophila melanogaster | Dmel_CG33890 | CG33890 gene product from transcript CG33890-RA |
Drosophila melanogaster | Dmel_CG33900 | CG33900 gene product from transcript CG33900-RA |
Drosophila melanogaster | Dmel_CG33880 | CG33880 gene product from transcript CG33880-RA |
Drosophila melanogaster | Dmel_CG33906 | CG33906 gene product from transcript CG33906-RA |
Drosophila melanogaster | Dmel_CG33868 | CG33868 gene product from transcript CG33868-RA |
Drosophila melanogaster | Dmel_CG33898 | CG33898 gene product from transcript CG33898-RA |
Drosophila melanogaster | Dmel_CG33886 | CG33886 gene product from transcript CG33886-RA |
Drosophila melanogaster | Dmel_CG33910 | CG33910 gene product from transcript CG33910-RA |
Drosophila melanogaster | Dmel_CG33902 | CG33902 gene product from transcript CG33902-RA |
Drosophila melanogaster | Dmel_CG33884 | CG33884 gene product from transcript CG33884-RA |
Drosophila melanogaster | Dmel_CG33878 | CG33878 gene product from transcript CG33878-RA |
Drosophila melanogaster | Dmel_CG33896 | CG33896 gene product from transcript CG33896-RA |
Drosophila melanogaster | Dmel_CG33892 | CG33892 gene product from transcript CG33892-RA |
Drosophila melanogaster | Dmel_CG17949 | CG17949 gene product from transcript CG17949-RA |
Drosophila melanogaster | Dmel_CG33882 | CG33882 gene product from transcript CG33882-RA |
Drosophila melanogaster | Dmel_CG33874 | CG33874 gene product from transcript CG33874-RA |
Drosophila melanogaster | Dmel_CG33894 | CG33894 gene product from transcript CG33894-RA |
Drosophila melanogaster | Dmel_CG33876 | CG33876 gene product from transcript CG33876-RA |
Echinococcus granulosus | EgrG_000322800 | histone H2B |
Echinococcus granulosus | EgrG_000306200 | histone cluster 1, H2bb |
Echinococcus granulosus | EgrG_000323300 | histone H2B |
Echinococcus granulosus | EgrG_000472800 | histone H2B |
Entamoeba histolytica | EHI_182990 | histone H2B, putative |
Entamoeba histolytica | EHI_188730 | histone H2B, putative |
Echinococcus multilocularis | EmuJ_000387800 | histone H2B |
Echinococcus multilocularis | EmuJ_000383700 | histone H2B |
Echinococcus multilocularis | EmuJ_000336700 | histone H2B |
Echinococcus multilocularis | EmuJ_000336500 | histone H2B |
Echinococcus multilocularis | EmuJ_000566500 | histone H2B |
Echinococcus multilocularis | EmuJ_000328600 | histone H2B |
Echinococcus multilocularis | EmuJ_000323300 | histone H2B |
Echinococcus multilocularis | EmuJ_000387300 | histone H2B |
Echinococcus multilocularis | EmuJ_000398500 | histone H2B |
Echinococcus multilocularis | EmuJ_000385200 | histone H2B |
Echinococcus multilocularis | EmuJ_000367300 | histone H2B |
Echinococcus multilocularis | EmuJ_000037500 | histone H2B |
Echinococcus multilocularis | EmuJ_000384300 | histone H2B |
Echinococcus multilocularis | EmuJ_000472800 | histone H2B |
Echinococcus multilocularis | EmuJ_000386300 | histone H2B |
Echinococcus multilocularis | EmuJ_001203100 | histone H2B |
Echinococcus multilocularis | EmuJ_000384800 | histone H2B |
Echinococcus multilocularis | EmuJ_000322800 | histone H2B |
Echinococcus multilocularis | EmuJ_000384000 | histone H2B |
Echinococcus multilocularis | EmuJ_000386000 | histone H2B |
Echinococcus multilocularis | EmuJ_000367600 | histone H2B |
Echinococcus multilocularis | EmuJ_000386800 | histone H2B |
Echinococcus multilocularis | EmuJ_000027400 | histone H2B |
Echinococcus multilocularis | EmuJ_000279100 | histone H2B |
Echinococcus multilocularis | EmuJ_000336900 | histone H2B |
Echinococcus multilocularis | EmuJ_000385700 | histone H2B |
Giardia lamblia | GL50803_121046 | Histone H2B |
Giardia lamblia | GL50803_121045 | Histone H2B |
Homo sapiens | ENSG00000146047 | histone cluster 1, H2ba |
Homo sapiens | ENSG00000184678 | histone cluster 2, H2be |
Homo sapiens | 8970 | histone cluster 1, H2bj |
Homo sapiens | ENSG00000278588 | histone cluster 1, H2bi |
Homo sapiens | ENSG00000185130 | histone cluster 1, H2bl |
Homo sapiens | ENSG00000277224 | histone cluster 1, H2bf |
Homo sapiens | 8339 | histone cluster 1, H2bg |
Homo sapiens | 85236 | histone cluster 1, H2bk |
Homo sapiens | ENSG00000274641 | histone cluster 1, H2bo |
Homo sapiens | ENSG00000158373 | histone cluster 1, H2bd |
Homo sapiens | 102724334 | histone H2B type F-S-like |
Homo sapiens | ENSG00000168298 | histone cluster 1, H1e |
Homo sapiens | ENSG00000274290 | histone cluster 1, H2be |
Homo sapiens | ENSG00000275713 | histone cluster 1, H2bh |
Homo sapiens | ENSG00000276410 | histone cluster 1, H2bb |
Homo sapiens | 8341 | histone cluster 1, H2bn |
Homo sapiens | 128312 | histone cluster 3, H2bb |
Homo sapiens | ENSG00000273703 | histone cluster 1, H2bm |
Homo sapiens | 8347 | histone cluster 1, H2bc |
Leishmania braziliensis | LbrM.28.0220 | histone H2B variant |
Leishmania braziliensis | LbrM.19.0350 | histone H2B |
Leishmania braziliensis | LbrM.19.0340 | histone H2B |
Leishmania braziliensis | LbrM.09.1400 | histone H2B |
Leishmania braziliensis | LbrM.19.0360 | histone H2B |
Leishmania donovani | LdBPK_190040.1 | histone H2B |
Leishmania donovani | LdBPK_280210.1 | Histone H2B variant V |
Leishmania donovani | LdBPK_171320.1 | histone H2B |
Leishmania donovani | LdBPK_091410.1 | histone H2B |
Leishmania infantum | LinJ.28.0210 | histone H2B variant |
Leishmania infantum | LinJ.09.1410 | histone H2B |
Leishmania infantum | LinJ.19.0030 | histone H2B |
Leishmania infantum | LinJ.19.0040 | histone H2B |
Leishmania infantum | LinJ.17.1320 | histone H2B |
Leishmania major | LmjF.28.0210 | histone H2B variant |
Leishmania major | LmjF.17.1220 | histone H2B |
Leishmania major | LmjF.19.0030 | histone H2B |
Leishmania major | LmjF.19.0040 | histone H2B |
Leishmania major | LmjF.09.1340 | histone H2B |
Leishmania major | LmjF.19.0050 | histone H2B |
Leishmania mexicana | LmxM.19.0030 | histone H2B |
Leishmania mexicana | LmxM.17.1220 | histone H2B |
Leishmania mexicana | LmxM.09.1340 | histone H2B |
Leishmania mexicana | LmxM.28.0210 | histone H2B variant |
Leishmania mexicana | LmxM.19.0050 | histone H2B |
Loa Loa (eye worm) | LOAG_10470 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14097 | histone H2B 2 |
Loa Loa (eye worm) | LOAG_10011 | hypothetical protein |
Mus musculus | ENSMUSG00000018102 | histone cluster 1, H2bc |
Mus musculus | ENSMUSG00000069307 | histone cluster 1, H2bq |
Mus musculus | 319181 | histone cluster 1, H2bg |
Mus musculus | ENSMUSG00000069300 | histone cluster 1, H2bj |
Mus musculus | ENSMUSG00000069308 | histone cluster 1, H2bp |
Mus musculus | ENSMUSG00000062727 | histone cluster 1, H2bk |
Mus musculus | ENSMUSG00000047246 | histone cluster 1, H2be |
Mus musculus | ENSMUSG00000095217 | histone cluster 1, H2bn |
Mus musculus | ENSMUSG00000069268 | histone cluster 1, H2bf |
Mus musculus | ENSMUSG00000075031 | histone cluster 1, H2bb |
Mus musculus | ENSMUSG00000068854 | histone cluster 2, H2be |
Mus musculus | ENSMUSG00000094338 | histone cluster 1, H2bl |
Mus musculus | ENSMUSG00000096807 | histone cluster 1, H2bm |
Mus musculus | 665622 | histone cluster 1 H2br |
Mus musculus | ENSMUSG00000056895 | histone cluster 3, H2ba |
Mus musculus | ENSMUSG00000050799 | histone cluster 1, H2ba |
Mus musculus | ENSMUSG00000064168 | histone cluster 1, H2bh |
Neospora caninum | NCLIV_066910 | Histone H2B, related |
Neospora caninum | NCLIV_001070 | Histone H2B, related |
Neospora caninum | NCLIV_004160 | Histone H2B, related |
Oryza sativa | 4324512 | Os01g0149600 |
Oryza sativa | 4324498 | Os01g0152700 |
Oryza sativa | 4324510 | Os01g0149400 |
Oryza sativa | 4345904 | Os08g0490900 |
Oryza sativa | 4324500 | Os01g0152900 |
Oryza sativa | 4324502 | Os01g0153100 |
Oryza sativa | 9267011 | Os01g0597201 |
Oryza sativa | 4324495 | Os01g0152300 |
Oryza sativa | 4339681 | Os05g0574300 |
Oryza sativa | 4324504 | Os01g0153300 |
Oryza sativa | 9268195 | Os09g0570850 |
Oryza sativa | 4327384 | Os01g0839500 |
Onchocerca volvulus | OVOC1239 |
|
Onchocerca volvulus | OVOC7893 |
|
Onchocerca volvulus | OVOC1638 |
|
Onchocerca volvulus | OVOC1639 |
|
Onchocerca volvulus | OVOC1235 |
|
Onchocerca volvulus | OVOC4061 |
|
Plasmodium berghei | PBANKA_1420600 | histone H2B variant, putative |
Plasmodium berghei | PBANKA_0941800 | histone H2B, putative |
Plasmodium falciparum | PF3D7_1105100 | histone H2B |
Plasmodium falciparum | PF3D7_0714000 | histone H2B variant |
Plasmodium knowlesi | PKNH_0902700 | histone H2B, putative |
Plasmodium knowlesi | PKNH_1422900 | histone H2B variant, putative |
Plasmodium vivax | PVX_122930 | histone H2B variant, putative |
Plasmodium vivax | PVX_090935 | histone 2B |
Plasmodium yoelii | PY02616 | histone H2B variant 1 |
Saccharomyces cerevisiae | YDR224C | histone H2B |
Saccharomyces cerevisiae | YBL002W | histone H2B |
Schistosoma japonicum | Sjp_0006730 | Histone H2B, gonadal, putative |
Schistosoma japonicum | Sjp_0314840 | expressed protein |
Schistosoma japonicum | Sjp_0036400 | Histone H2B, putative |
Schistosoma japonicum | Sjp_0016080 | Histone H2B, gonadal, putative |
Schistosoma japonicum | Sjp_0036390 | Histone H2B, gonadal, putative |
Schistosoma mansoni | Smp_036220 | histone H2B |
Schistosoma mansoni | Smp_108390 | histone H2B |
Schistosoma mansoni | Smp_121380 | histone H2B |
Schmidtea mediterranea | mk4.023146.01 | |
Schmidtea mediterranea | mk4.015823.02 | |
Schmidtea mediterranea | mk4.000688.07 | Histone H2B |
Schmidtea mediterranea | mk4.000572.09 | Histone H2B |
Schmidtea mediterranea | mk4.019784.02 | |
Schmidtea mediterranea | mk4.002212.01 | Histone H2B |
Schmidtea mediterranea | mk4.045597.00 | |
Schmidtea mediterranea | mk4.005020.01 | Histone H2B |
Schmidtea mediterranea | mk4.000688.06 | Histone H2B |
Schmidtea mediterranea | mk4.021105.00 | Histone H2B |
Schmidtea mediterranea | mk4.000124.04 | Histone H2B |
Schmidtea mediterranea | mk4.014609.00 | |
Schmidtea mediterranea | mk4.000756.08 | Histone H2B |
Schmidtea mediterranea | mk4.006479.00 | Histone H2B |
Schmidtea mediterranea | mk4.000063.03 | Histone H2B |
Schmidtea mediterranea | mk4.000525.05 | |
Schmidtea mediterranea | mk4.014939.01 | Histone H2B |
Schmidtea mediterranea | mk4.008285.00 | |
Schmidtea mediterranea | mk4.013070.00 | |
Schmidtea mediterranea | mk4.011360.01 | |
Trypanosoma brucei gambiense | Tbg972.10.12830 | histone H2B, putative |
Trypanosoma brucei gambiense | Tbg972.10.12840 | histone H2B, putative |
Trypanosoma brucei gambiense | Tbg972.11.8400 | histone H2B variant, putative |
Trypanosoma brucei gambiense | Tbg972.10.12780 | histone H2B, putative |
Trypanosoma brucei gambiense | Tbg972.10.12800 | histone H2B, putative |
Trypanosoma brucei gambiense | Tbg972.10.12740 | histone H2B, putative |
Trypanosoma brucei gambiense | Tbg972.10.12770 | histone H2B, putative |
Trypanosoma brucei gambiense | Tbg972.10.12790 | histone H2B, putative |
Trypanosoma brucei gambiense | Tbg972.10.12810 | histone H2B, putative |
Trypanosoma brucei gambiense | Tbg972.10.12750 | histone H2B, putative |
Trypanosoma brucei gambiense | Tbg972.10.12820 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10560 | histone H2B, putative |
Trypanosoma brucei | Tb927.11.7350 | Histone H2B variant V |
Trypanosoma brucei | Tb927.10.10590 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10460 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10490 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10540 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10480 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10580 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10470 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10530 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10570 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10510 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10550 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10500 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10520 | histone H2B, putative |
Trypanosoma brucei | Tb927.10.10445 | Core histone H2A/H2B/H3/H4, putative |
Trypanosoma congolense | TcIL3000_10_8920 | histone H2B, putative |
Trypanosoma congolense | TcIL3000_10_8910 | histone H2B, putative |
Trypanosoma cruzi | TcCLB.511635.10 | histone H2B, putative |
Trypanosoma cruzi | TcCLB.511153.64 | Histone H2B variant V |
Trypanosoma cruzi | TcCLB.506779.150 | Histone H2B variant V |
Trypanosoma cruzi | TcCLB.511635.20 | histone H2B, putative |
Toxoplasma gondii | TGME49_251870 | histone H2Bb |
Toxoplasma gondii | TGME49_209910 | histone H2Bv |
Toxoplasma gondii | TGME49_305160 | histone H2Ba |
Theileria parva | TP04_0404 | histone H2B-III, putative |
Theileria parva | TP04_0071 | histone H2B, putative |
Trichomonas vaginalis | TVAG_268820 | histone H2b, putative |
Trichomonas vaginalis | TVAG_321390 | histone H2b, putative |
Trichomonas vaginalis | TVAG_380920 | histone H2b, putative |
Trichomonas vaginalis | TVAG_195300 | histone H2b, putative |
Trichomonas vaginalis | TVAG_329270 | histone H2b, putative |
Trichomonas vaginalis | TVAG_226780 | histone H2b, putative |
Trichomonas vaginalis | TVAG_464720 | histone H2b, putative |
Trichomonas vaginalis | TVAG_045410 | histone H2b, putative |
Trichomonas vaginalis | TVAG_105960 | histone H2b, putative |
Trichomonas vaginalis | TVAG_026390 | histone H2b, putative |
Trichomonas vaginalis | TVAG_447850 | histone H2b, putative |
Trichomonas vaginalis | TVAG_144040 | histone H2b, putative |
Trichomonas vaginalis | TVAG_228640 | histone H2b, putative |
Trichomonas vaginalis | TVAG_075290 | histone H2b, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.10590 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.10590 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.10590 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.10590 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.10460 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.10460 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.10460 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.10460 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.5250 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5250 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5250 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.5250 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T10C6.11 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_T10C6.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T10C6.11 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_T10C6.11 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T10C6.11 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T10C6.11 | Caenorhabditis elegans | sterile | wormbase |
CELE_F45F2.12 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F45F2.12 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F45F2.12 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F45F2.12 | Caenorhabditis elegans | sterile | wormbase |
CELE_ZK131.5 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_ZK131.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK131.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZK131.5 | Caenorhabditis elegans | slow growth | wormbase |
CELE_ZK131.5 | Caenorhabditis elegans | sterile | wormbase |
CELE_ZK131.9 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_ZK131.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_ZK131.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_ZK131.9 | Caenorhabditis elegans | slow growth | wormbase |
CELE_ZK131.9 | Caenorhabditis elegans | sterile | wormbase |
CELE_K06C4.4 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_K06C4.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K06C4.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K06C4.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K06C4.4 | Caenorhabditis elegans | sterile | wormbase |
CELE_K06C4.12 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_K06C4.12 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K06C4.12 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K06C4.12 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K06C4.12 | Caenorhabditis elegans | sterile | wormbase |
CELE_F35H10.11 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F35H10.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F35H10.11 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F35H10.11 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F17E9.9 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F17E9.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F17E9.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F17E9.9 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C50F4.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C50F4.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C50F4.5 | Caenorhabditis elegans | sterile | wormbase |
CELE_F08G2.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F08G2.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F08G2.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F08G2.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F08G2.1 | Caenorhabditis elegans | sterile | wormbase |
CELE_B0035.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_B0035.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_B0035.8 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_B0035.8 | Caenorhabditis elegans | slow growth | wormbase |
CELE_B0035.8 | Caenorhabditis elegans | sterile | wormbase |
CELE_F07B7.4 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F07B7.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F07B7.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F07B7.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F07B7.4 | Caenorhabditis elegans | sterile | wormbase |
CELE_F07B7.11 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_F07B7.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F07B7.11 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F07B7.11 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F07B7.11 | Caenorhabditis elegans | sterile | wormbase |
CELE_F54E12.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F54E12.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F54E12.4 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F54E12.4 | Caenorhabditis elegans | sterile | wormbase |
CELE_F55G1.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F55G1.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F55G1.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_H02I12.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H02I12.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_H02I12.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_H02I12.6 | Caenorhabditis elegans | sterile | wormbase |
YDR224C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0941800 | Plasmodium berghei | Essential | plasmo |
PBANKA_1420600 | Plasmodium berghei | Essential | plasmo |
TGME49_305160 | Toxoplasma gondii | Probably essential | sidik |
TGME49_251870 | Toxoplasma gondii | Probably essential | sidik |
TGME49_209910 | Toxoplasma gondii | Probably essential | sidik |
TGME49_305160 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_251870 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_209910 | Toxoplasma gondii | Probably non-essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.