pI: 5.0411 |
Length (AA): 251 |
MW (Da): 27299 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127593)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G14290 | 20S proteasome alpha subunit E2 |
Arabidopsis thaliana | AT1G53850 | proteasome subunit alpha type-5-A |
Babesia bovis | BBOV_I001480 | proteasome alpha 5 subunit, putative |
Brugia malayi | Bm1_37390 | 20S proteasome alpha5 subunit |
Candida albicans | CaO19.8328 | similar to S. cerevisiae PUP2 (YGR253C) proteasome subunit |
Candida albicans | CaO19.709 | similar to S. cerevisiae PUP2 (YGR253C) proteasome subunit |
Caenorhabditis elegans | CELE_F25H2.9 | Protein PAS-5 |
Cryptosporidium hominis | Chro.50200 | proteasome subunit alpha type 5 |
Cryptosporidium parvum | cgd5_1820 | proteasome subunit alpha type 5 |
Dictyostelium discoideum | DDB_G0268538 | 20S proteasome subunit alpha-5 |
Drosophila melanogaster | Dmel_CG10938 | Proteasome alpha5 subunit |
Echinococcus granulosus | EgrG_001182700 | subfamily T1A non peptidase ue |
Entamoeba histolytica | EHI_023020 | proteasome subunit alpha type 5, putative |
Entamoeba histolytica | EHI_004760 | proteasome subunit alpha type 5, putative |
Echinococcus multilocularis | EmuJ_001182700 | subfamily T1A non peptidase ue |
Giardia lamblia | GL50803_2980 | 20S proteasome alpha subunit 5 |
Homo sapiens | ENSG00000143106 | proteasome (prosome, macropain) subunit, alpha type, 5 |
Leishmania braziliensis | LbrM.33.0890 | proteasome alpha 5 subunit, putative |
Leishmania donovani | LdBPK_212200.1 | proteasome subunit alpha type-5, putative |
Leishmania infantum | LinJ.21.2200 | proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) |
Leishmania major | LmjF.21.1830 | proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) |
Leishmania mexicana | LmxM.21.1830 | proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) |
Loa Loa (eye worm) | LOAG_01073 | 20S proteasome alpha5 subunit |
Mus musculus | ENSMUSG00000068749 | proteasome (prosome, macropain) subunit, alpha type 5 |
Neospora caninum | NCLIV_065750 | Alpha 2 subunit of 20S proteasome (ISS), related |
Oryza sativa | 4350922 | Os11g0615700 |
Plasmodium berghei | PBANKA_0211500 | proteasome subunit alpha type-5, putative |
Plasmodium falciparum | PF3D7_0727400 | proteasome subunit alpha type-5, putative |
Plasmodium knowlesi | PKNH_0212000 | proteasome subunit alpha type-5, putative |
Plasmodium vivax | PVX_081675 | proteasome subunit alpha type-5, putative |
Plasmodium yoelii | PY02094 | proteasome subunit alpha type 5 |
Saccharomyces cerevisiae | YGR253C | proteasome core particle subunit alpha 5 |
Schistosoma mansoni | Smp_032580.2 | subfamily T1A non-peptidase homologue (T01 family) |
Schistosoma mansoni | Smp_032580.3 | subfamily T1A non-peptidase homologue (T01 family) |
Schistosoma mansoni | Smp_032580.1 | subfamily T1A non-peptidase homologue (T01 family) |
Schmidtea mediterranea | mk4.001348.01 | Proteasome subunit alpha type |
Schmidtea mediterranea | mk4.006696.00 | Proteasome subunit alpha type |
Trypanosoma brucei gambiense | Tbg972.10.140 | proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5 |
Trypanosoma brucei | Tb927.10.230 | proteasome subunit alpha type-5, putative |
Trypanosoma congolense | TcIL3000_10_90 | proteasome subunit alpha type-5, putative |
Trypanosoma cruzi | TcCLB.511145.43 | proteasome subunit alpha type-5, putative |
Trypanosoma cruzi | TcCLB.504069.53 | proteasome subunit alpha type-5, putative |
Toxoplasma gondii | TGME49_249590 | proteasome subunit alpha type 5-2, putative |
Theileria parva | TP01_1231 | proteasome subunit alpha type 5, putative |
Trichomonas vaginalis | TVAG_293540 | Family T1, proteasome alpha subunit, threonine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.230 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.230 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.230 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.230 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F25H2.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F25H2.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F25H2.9 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_F25H2.9 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F25H2.9 | Caenorhabditis elegans | sterile | wormbase |
YGR253C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0211500 | Plasmodium berghei | Essential | plasmo |
TGME49_249590 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, alpha type, 5 | Compounds | References |