Detailed view for TVAG_452050

Basic information

TDR Targets ID: 927653
Trichomonas vaginalis, Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Source Database / ID: 

pI: 5.1166 | Length (AA): 1455 | MW (Da): 170288 | Paralog Number: 19

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00443   Ubiquitin carboxyl-terminal hydrolase
PF03184   DDE superfamily endonuclease

Gene Ontology

Mouse over links to read term descriptions.
GO:0036459   GO:thiol-dependent ubiquitinyl hydrolase activity  

GO:0016579   protein deubiquitination  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_136101)

Species Accession Gene Product
Trichomonas vaginalis TVAG_218360   conserved hypothetical protein
Trichomonas vaginalis TVAG_397950   conserved hypothetical protein
Trichomonas vaginalis TVAG_452040   conserved hypothetical protein
Trichomonas vaginalis TVAG_514870   conserved hypothetical protein
Trichomonas vaginalis TVAG_RG_DS113824_1   hypothetical protein
Trichomonas vaginalis TVAG_072470   conserved hypothetical protein
Trichomonas vaginalis TVAG_067240   cenp-B, putative
Trichomonas vaginalis TVAG_526520   conserved hypothetical protein
Trichomonas vaginalis TVAG_545670   conserved hypothetical protein
Trichomonas vaginalis TVAG_510270   conserved hypothetical protein
Trichomonas vaginalis TVAG_526510   conserved hypothetical protein
Trichomonas vaginalis TVAG_148110   conserved hypothetical protein
Trichomonas vaginalis TVAG_452050   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_604360   conserved hypothetical protein
Trichomonas vaginalis TVAG_528010   conserved hypothetical protein
Trichomonas vaginalis TVAG_287310   conserved hypothetical protein
Trichomonas vaginalis TVAG_602030   conserved hypothetical protein
Trichomonas vaginalis TVAG_068120   conserved hypothetical protein
Trichomonas vaginalis TVAG_545680   conserved hypothetical protein
Trichomonas vaginalis TVAG_581560   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0004 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_452050 (Trichomonas vaginalis), Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
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