Detailed view for TVAG_202560

Basic information

TDR Targets ID: 928582
Trichomonas vaginalis, voltage and ligand gated potassium channel, putative
Source Database / ID: 

pI: 7.8234 | Length (AA): 547 | MW (Da): 63249 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain
PF07885   Ion channel

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005249   voltage-gated potassium channel activity  
GO:0006813   potassium ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126589)

Species Accession Gene Product
Brugia malayi Bm1_05590   Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog
Caenorhabditis elegans CELE_ZC84.2   Protein TAX-4
Drosophila melanogaster Dmel_CG42701   Cyclic nucleotide-gated ion channel subunit A
Echinococcus granulosus EgrG_001023300   cyclic nucleotide gated cation channel alpha 3
Echinococcus multilocularis EmuJ_001023300   cyclic nucleotide gated cation channel alpha 3
Homo sapiens ENSG00000144191   cyclic nucleotide gated channel alpha 3
Homo sapiens ENSG00000198515   cyclic nucleotide gated channel alpha 1
Homo sapiens ENSG00000183862   cyclic nucleotide gated channel alpha 2
Loa Loa (eye worm) LOAG_02956   cyclic-nucleotide gated cation channel
Mus musculus ENSMUSG00000067220   cyclic nucleotide gated channel alpha 1
Mus musculus ENSMUSG00000005864   cyclic nucleotide gated channel alpha 2
Mus musculus ENSMUSG00000026114   cyclic nucleotide gated channel alpha 3
Schistosoma japonicum Sjp_0015630   Cyclic nucleotide-gated cation channel, putative
Schistosoma japonicum Sjp_0110920   Cyclic nucleotide-gated cation channel, putative
Schistosoma mansoni Smp_194700   cyclic-nucleotide-gated cation channel
Schmidtea mediterranea mk4.009317.01   Cyclic nucleotide-gated cation channel subunit A
Schmidtea mediterranea mk4.007707.02   Cyclic nucleotide-gated cation channel
Schmidtea mediterranea mk4.014690.00   Cyclic nucleotide-gated cation channel
Schmidtea mediterranea mk4.012464.03  
Schmidtea mediterranea mk4.005662.00   Cyclic nucleotide-gated cation channel
Schmidtea mediterranea mk4.007821.00   Cyclic nucleotide-gated cation channel subunit A
Trichomonas vaginalis TVAG_343570   voltage and ligand gated potassium channel, putative
Trichomonas vaginalis TVAG_202560   voltage and ligand gated potassium channel, putative
Trichomonas vaginalis TVAG_003870   voltage and ligand gated potassium channel, putative
Trichomonas vaginalis TVAG_424290   voltage and ligand gated potassium channel, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus cGMP-gated cation channel alpha 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0182 0.3227 0.5801
0.0141 0.2735 0.4478
0.00187922 0.347879 0.299794
0.0173 0.3241 0.5812

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_202560 (Trichomonas vaginalis), voltage and ligand gated potassium channel, putative
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