pI: 5.9742 |
Length (AA): 687 |
MW (Da): 78145 |
Paralog Number:
13
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_127530)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G48490 | putative protein kinase |
Arabidopsis thaliana | AT5G62310 | putative serine/threonine protein kinase IRE |
Arabidopsis thaliana | AT1G45160 | protein kinase |
Arabidopsis thaliana | AT3G17850 | protein kinase family protein |
Brugia malayi | Bm1_57280 | KIAA0303 |
Caenorhabditis elegans | CELE_C10C6.1 | Protein KIN-4, isoform B |
Dictyostelium discoideum | DDB_G0272282 | MAST family protein kinase |
Drosophila melanogaster | Dmel_CG6498 | CG6498 gene product from transcript CG6498-RB |
Echinococcus granulosus | EgrG_000454700 | Microtubule-associated serine/threonine-protein kinase |
Entamoeba histolytica | EHI_006750 | protein kinase, putative |
Entamoeba histolytica | EHI_193290 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000712200 | serine:threonine protein kinase greatwall |
Echinococcus multilocularis | EmuJ_000454700 | microtubule associated serine:threonine protein |
Homo sapiens | ENSG00000105613 | microtubule associated serine/threonine kinase 1 |
Homo sapiens | ENSG00000069020 | microtubule associated serine/threonine kinase family member 4 |
Homo sapiens | ENSG00000099308 | microtubule associated serine/threonine kinase 3 |
Homo sapiens | ENSG00000086015 | microtubule associated serine/threonine kinase 2 |
Loa Loa (eye worm) | LOAG_07481 | AGC/MAST/MAST protein kinase |
Mus musculus | ENSMUSG00000031833 | microtubule associated serine/threonine kinase 3 |
Mus musculus | ENSMUSG00000053693 | microtubule associated serine/threonine kinase 1 |
Mus musculus | ENSMUSG00000003810 | microtubule associated serine/threonine kinase 2 |
Mus musculus | ENSMUSG00000034751 | microtubule associated serine/threonine kinase family member 4 |
Oryza sativa | 4333889 | Os03g0711800 |
Oryza sativa | 4352821 | Os12g0621500 |
Schistosoma mansoni | Smp_174820 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.000282.03 | |
Schmidtea mediterranea | mk4.000085.04 | |
Schmidtea mediterranea | mk4.002603.00 | |
Schmidtea mediterranea | mk4.002041.01 | |
Trichomonas vaginalis | TVAG_479710 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_312180 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_347430 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_030400 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_587270 | serine/threonine-protein kinase, putative |
Trichomonas vaginalis | TVAG_011160 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_470980 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_359020 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_346740 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_047880 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_405930 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_504520 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_597230 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_020880 | AGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C10C6.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | microtubule associated serine/threonine kinase 1 | Compounds | References |
Homo sapiens | microtubule associated serine/threonine kinase 3 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 35.8% | 335 aa | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 28.1% | 331 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 26.7% | 303 aa | Compounds | References |
Bos taurus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 37.7% | 316 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 26.3% | 304 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 28.5% | 305 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 25.8% | 291 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 27.8% | 302 aa | Compounds | References |
Oryctolagus cuniculus | cAMP-dependent protein kinase alpha-catalytic subunit | 351 aa | 37.0% | 316 aa | Compounds | References |