Detailed view for TVAG_090450

Basic information

TDR Targets ID: 930051
Trichomonas vaginalis, Clan SB, family S8, subtilisin-like serine peptidase
Source Database / ID: 

pI: 5.563 | Length (AA): 857 | MW (Da): 95160 | Paralog Number: 21

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00082   Subtilase family

Gene Ontology

Mouse over links to read term descriptions.
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132402)

Species Accession Gene Product
Oryza sativa 4335100   Os04g0182300
Trypanosoma brucei gambiense Tbg972.3.4650   subtilisin-like serine peptidase, putative,serine peptidase, clan SB, family S8-like protein, putative
Trypanosoma brucei Tb927.3.4230   serine peptidase, clan SB, family S8-like protein
Trichomonas vaginalis TVAG_090450   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_162950   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_079860   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_090250   conserved hypothetical protein
Trichomonas vaginalis TVAG_109360   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_035830   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_045540   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_213290   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_230700   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_035840   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_151300   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_482670   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_376790   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_124770   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_054370   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_227060   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_418990   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_584430   conserved hypothetical protein
Trichomonas vaginalis TVAG_062550   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_379760   Clan SB, family S8, subtilisin-like serine peptidase
Trichomonas vaginalis TVAG_233670   conserved hypothetical protein
Trichomonas vaginalis TVAG_003700   Clan SB, family S8, subtilisin-like serine peptidase

Essentiality

TVAG_090450 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.4230 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.4230 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.4230 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.4230 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bacillus lentus Subtilisin 269 aa 24.7% 219 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_090450 (Trichomonas vaginalis), Clan SB, family S8, subtilisin-like serine peptidase
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