pI: 9.0157 |
Length (AA): 427 |
MW (Da): 47107 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128027)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G22310 | ubiquitin carboxyl-terminal hydrolase 4 |
Arabidopsis thaliana | AT4G39910 | ubiquitin-specific protease 3 |
Brugia malayi | Bm1_16930 | ubiquitin carboxyl-terminal hydrolase 46 |
Candida albicans | CaO19.9575 | ubiquitin carboxyl-terminal hydrolase |
Candida albicans | CaO19.2026 | ubiquitin carboxyl-terminal hydrolase |
Caenorhabditis elegans | CELE_R10E11.3 | Protein USP-46, isoform A |
Dictyostelium discoideum | DDB_G0290453 | peptidase C19 family protein |
Drosophila melanogaster | Dmel_CG7023 | Ubiquitin-specific protease 12/46 ortholog |
Echinococcus granulosus | EgrG_001076800 | set and mynd domain containing protein |
Echinococcus granulosus | EgrG_000915600 | ubiquitin carboxyl terminal hydrolase 12 |
Echinococcus multilocularis | EmuJ_000915600 | ubiquitin carboxyl terminal hydrolase 12 |
Echinococcus multilocularis | EmuJ_001076800 | set and mynd domain containing protein |
Homo sapiens | ENSG00000152484 | ubiquitin specific peptidase 12 |
Homo sapiens | ENSG00000109189 | ubiquitin specific peptidase 46 |
Leishmania braziliensis | LbrM.21.0460 | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Leishmania donovani | LdBPK_210460.1 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative |
Leishmania infantum | LinJ.21.0460 | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Leishmania major | LmjF.21.0400 | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Leishmania mexicana | LmxM.21.0400 | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Loa Loa (eye worm) | LOAG_08169 | ubiquitin carboxyl-terminal hydrolase 46 |
Mus musculus | ENSMUSG00000029640 | ubiquitin specific peptidase 12 |
Mus musculus | 69727 | ubiquitin specific peptidase 46 |
Oryza sativa | 4336009 | Os04g0452400 |
Oryza sativa | 4331901 | Os03g0190800 |
Oryza sativa | 4329740 | Os02g0573400 |
Saccharomyces cerevisiae | YBL067C | Ubp13p |
Saccharomyces cerevisiae | YER098W | Ubp9p |
Schistosoma japonicum | Sjp_0202330 | SET and MYND domain-containing protein 4, putative |
Schistosoma japonicum | Sjp_0106640 | ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative |
Schistosoma mansoni | Smp_000710 | ubiquitin-specific peptidase 46 (C19 family) |
Schmidtea mediterranea | mk4.007842.04 | |
Schmidtea mediterranea | mk4.001889.03 | Ubiquitin carboxyl-terminal hydrolase |
Schmidtea mediterranea | mk4.010148.00 | |
Trypanosoma brucei gambiense | Tbg972.10.2680 | ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Trypanosoma brucei | Tb11.v5.0701 | ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma brucei | Tb927.10.2210 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma congolense | TcIL3000_10_1820 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma cruzi | TcCLB.511367.260 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative |
Theileria parva | TP02_0111 | hypothetical protein |
Trichomonas vaginalis | TVAG_268770 | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.2210 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.2210 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.2210 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.2210 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | Compounds | References |