pI: 6.8699 |
Length (AA): 448 |
MW (Da): 48710 |
Paralog Number:
1010
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
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In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
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Capra hircus | Cathepsin H | 335 aa | 35.7% | 325 aa | Compounds | References |
Oryctolagus cuniculus | Cathepsin K | 329 aa | 34.4% | 323 aa | Compounds | References |
Rattus norvegicus | Cathepsin K | 329 aa | 33.5% | 337 aa | Compounds | References |
Canis familiaris | Cathepsin K | 330 aa | 35.9% | 329 aa | Compounds | References |
Rattus norvegicus | Cathepsin L | 334 aa | 39.5% | 329 aa | Compounds | References |
Leishmania major | cathepsin L-like protease | 443 aa | 44.2% | 412 aa | Compounds | References |
Bos taurus | Cathepsin L | 334 aa | 37.7% | 337 aa | Compounds | References |
Leishmania major | cathepsin L-like protease | 348 aa | 53.9% | 310 aa | Compounds | References |
Dermatophagoides pteronyssinus | Peptidase 1 | 320 aa | 30.4% | 316 aa | Compounds | References |
Rattus norvegicus | Cathepsin S | 330 aa | 33.8% | 308 aa | Compounds | References |
Leishmania major | cathepsin L-like protease | 348 aa | 53.9% | 310 aa | Compounds | References |
Leishmania major | cathepsin L-like protease | 348 aa | 53.5% | 310 aa | Compounds | References |
Leishmania major | cathepsin L-like protease | 348 aa | 53.2% | 310 aa | Compounds | References |
Carica papaya | Papain | 345 aa | 33.5% | 328 aa | Compounds | References |
Leishmania major | cathepsin L-like protease | 348 aa | 52.9% | 310 aa | Compounds | References |
Leishmania major | cathepsin L-like protease | 443 aa | 44.4% | 412 aa | Compounds | References |
Leishmania major | cysteine peptidase A (CPA) | 354 aa | 46.9% | 343 aa | Compounds | References |
Leishmania major | cathepsin L-like protease | 443 aa | 44.4% | 412 aa | Compounds | References |