pI: 4.8854 |
Length (AA): 550 |
MW (Da): 62716 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 550 | 2csx (A) | 3 | 496 | 27.00 | 0 | 1 | 1.11178 | 0.24 |
4 | 550 | 5gl7 (A) | 264 | 806 | 29.00 | 0 | 1 | 1.39405 | -0.61 |
5 | 550 | 1rqg (A) | 3 | 549 | 39.00 | 0 | 1 | 1.43133 | -0.49 |
378 | 544 | 4xkz (A) | 633 | 802 | 15.00 | 0 | 0.72 | 0.562236 | -0.97 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127626)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G13780 | probable methionine--tRNA ligase |
Babesia bovis | BBOV_IV006630 | methionyl-tRNA synthetase, putative |
Brugia malayi | Bm1_12165 | methionyl-tRNA synthetase |
Candida albicans | CaO19.3955 | likely tRNA synthetase similar to S. cerevisiae MES1 (YGR264C) cytoplasmic methionyl tRNA synthetase |
Candida albicans | CaO19.11437 | likely tRNA synthetase similar to S. cerevisiae MES1 (YGR264C) cytoplasmic methionyl tRNA synthetase |
Caenorhabditis elegans | CELE_F58B3.5 | Protein MARS-1, isoform B |
Chlamydia trachomatis | CT_032 | methionine--tRNA ligase |
Dictyostelium discoideum | DDB_G0279113 | methionine-tRNA ligase |
Drosophila melanogaster | Dmel_CG15100 | CG15100 gene product from transcript CG15100-RA |
Escherichia coli | b2114 | methionyl-tRNA synthetase |
Echinococcus granulosus | EgrG_000972000 | methionyl tRNA synthetase cytoplasmic |
Entamoeba histolytica | EHI_079860 | methionyl-tRNA synthetase, putative |
Echinococcus multilocularis | EmuJ_000972000 | methionyl tRNA synthetase, cytoplasmic |
Homo sapiens | ENSG00000166986 | methionyl-tRNA synthetase |
Loa Loa (eye worm) | LOAG_04595 | hypothetical protein |
Loa Loa (eye worm) | LOAG_04596 | multisynthetase complex auxiliary component p43 |
Mus musculus | ENSMUSG00000040354 | methionine-tRNA synthetase |
Oryza sativa | 4341140 | Os06g0508700 |
Oryza sativa | 4348562 | Os10g0400100 |
Saccharomyces cerevisiae | YGR264C | methionine--tRNA ligase MES1 |
Schistosoma japonicum | Sjp_0048360 | Methionyl-tRNA synthetase, cytoplasmic, putative |
Schistosoma japonicum | Sjp_0105270 | ko:K01874 methionyl-tRNA synthetase [EC6.1.1.10], putative |
Schistosoma mansoni | Smp_040770 | methionine-tRNA synthetase |
Schmidtea mediterranea | mk4.002973.01 | |
Schmidtea mediterranea | mk4.034972.04 | |
Schmidtea mediterranea | mk4.002973.00 | Putative methionine-tRNA synthetase |
Schmidtea mediterranea | mk4.000849.02 | Putative methionine-tRNA synthetase |
Treponema pallidum | TP0798 | methionyl-tRNA synthetase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b2114 | Escherichia coli | essential | goodall |
CELE_F58B3.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F58B3.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F58B3.5 | Caenorhabditis elegans | slow growth | wormbase |
YGR264C | Saccharomyces cerevisiae | inviable | yeastgenome |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Escherichia coli | methionyl-tRNA synthetase | Compounds | References |
Homo sapiens | methionyl-tRNA synthetase | Compounds | References |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | Methionyl-tRNA synthetase | Compounds | References |