Detailed view for CT_650

Basic information

TDR Targets ID: 934705
Chlamydia trachomatis, recombinase RecA
Source Database / ID:  KEGG  

pI: 7.3744 | Length (AA): 352 | MW (Da): 37830 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00154   recA bacterial DNA recombination protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0008094   DNA-dependent ATPase activity  
GO:0005524   ATP binding  
GO:0003697   single-stranded DNA binding  
GO:0003677   DNA binding  
GO:0006281   DNA repair  
GO:0006259   DNA metabolic process  

Metabolic Pathways

Homologous recombination (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 350 3cmu (A) 1001 2015 56.00 0 1 1.65052 -0.33
4 351 2g88 (A) 6 346 59.00 0 1 1.56654 0.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130095)

Species Accession Gene Product
Arabidopsis thaliana AT1G79050   DNA repair protein recA-like 1
Arabidopsis thaliana AT2G19490   recA DNA recombination family protein
Chlamydia trachomatis CT_650   recombinase RecA
Dictyostelium discoideum DDB_G0276073   DNA recombination protein
Escherichia coli b2699   DNA recombination and repair protein
Mycobacterium leprae ML0987   RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN].
Mycobacterium tuberculosis Rv2737c   RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)].
Mycobacterium ulcerans MUL_3380   recombinase A
Oryza sativa 4325041   Os01g0901200
Oryza sativa 4333537   Os03g0639700
Treponema pallidum TP0692   recombinase A
Wolbachia endosymbiont of Brugia malayi Wbm0427   recombinase A

Essentiality

CT_650 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2783 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CT_650 (Chlamydia trachomatis), recombinase RecA
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