Detailed view for CT_685

Basic information

TDR Targets ID: 935085
Chlamydia trachomatis, iron-sulfur assembly protein SufC
Source Database / ID:  KEGG  

pI: 4.7767 | Length (AA): 255 | MW (Da): 28429 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0016887   ATPase activity  
GO:0005524   ATP binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 250 2zu0 (C) 1 246 44.00 0 1 1.52489 -0.54
1 245 2zu0 (C) 1 241 50.00 0 1 1.64938 -1.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130065)

Species Accession Gene Product
Arabidopsis thaliana AT3G10670   plastidic SufC-like ATP-binding cassette/ATPase
Chlamydia trachomatis CT_685   iron-sulfur assembly protein SufC
Escherichia coli b1682   SufBCD Fe-S cluster assembly scaffold protein, ATP-binding protein
Mycobacterium leprae ML0595   Probable conserved ATP-binding protein ABC transporter
Mycobacterium tuberculosis Rv1463   Probable conserved ATP-binding protein ABC transporter
Mycobacterium ulcerans MUL_1864   ABC transporter ATP-binding protein
Neospora caninum NCLIV_047030   ABC transporter, putative
Oryza sativa 4332739   Os03g0332700
Plasmodium berghei PBANKA_1029200   FeS assembly ATPase SufC
Plasmodium falciparum PF3D7_1413500   FeS assembly ATPase SufC
Plasmodium knowlesi PKNH_1344800   FeS assembly ATPase SufC, putative
Plasmodium vivax PVX_085775   FeS assembly ATPase SufC, putative
Schmidtea mediterranea mk4.059263.00  
Toxoplasma gondii TGME49_225800   iron-sulfur assembly ATPase
Treponema pallidum TP0611   ABC transporter, ATP-binding protein

Essentiality

CT_685 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1486 Mycobacterium tuberculosis essential nmpdr
b1682 Escherichia coli non-essential goodall
PBANKA_1029200 Plasmodium berghei Essential plasmo
TGME49_225800 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier CT_685 (Chlamydia trachomatis), iron-sulfur assembly protein SufC
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