Detailed view for LOAG_08369

Basic information

TDR Targets ID: 935524
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.2302 | Length (AA): 456 | MW (Da): 52614 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13385   Concanavalin A-like lectin/glucanases superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0008237   metallopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
295 327 1pb5 (A) 4 34 48.00 0 0.51 0.498068 0.2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132115)

Species Accession Gene Product
Brugia malayi Bm1_30645   pregnancy-associated plasma protein-A
Brugia malayi Bm1_30630   hypothetical protein
Homo sapiens ENSG00000182752   pregnancy-associated plasma protein A, pappalysin 1
Homo sapiens ENSG00000116183   pappalysin 2
Loa Loa (eye worm) LOAG_08369   hypothetical protein
Loa Loa (eye worm) LOAG_08366   pregnancy-associated plasma protein-E
Loa Loa (eye worm) LOAG_08368   hypothetical protein
Loa Loa (eye worm) LOAG_13586   pregnancy-associated plasma protein-A
Mus musculus ENSMUSG00000028370   pregnancy-associated plasma protein A
Mus musculus ENSMUSG00000073530   pappalysin 2
Onchocerca volvulus OVOC3524  
Onchocerca volvulus OVOC3526  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08369 (Loa Loa (eye worm)), hypothetical protein
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