pI: 5.9875 |
Length (AA): 285 |
MW (Da): 32590 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
49 | 277 | 5o5l (A) | 211 | 427 | 32.00 | 0 | 1 | 1.17021 | -0.25 |
85 | 271 | 1azs (B) | 880 | 1075 | 60.00 | 0 | 1 | 1.46624 | -1.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126919)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_53800 | Adenylyl cyclase protein |
Caenorhabditis elegans | CELE_T01C2.1 | Protein ACY-4 |
Caenorhabditis elegans | CELE_C10F3.3 | Protein ACY-2 |
Drosophila melanogaster | Dmel_CG9533 | rutabaga |
Drosophila melanogaster | Dmel_CG1506 | CG1506 gene product from transcript CG1506-RA |
Drosophila melanogaster | Dmel_CG43373 | CG43373 gene product from transcript CG43373-RB |
Drosophila melanogaster | Dmel_CG10564 | Adenylyl cyclase 78C |
Echinococcus granulosus | EgrG_000483100 | adenylate cyclase 9 |
Echinococcus multilocularis | EmuJ_000483100 | adenylate cyclase 9 |
Homo sapiens | ENSG00000138031 | adenylate cyclase 3 |
Homo sapiens | ENSG00000121281 | adenylate cyclase 7 |
Homo sapiens | ENSG00000164742 | adenylate cyclase 1 (brain) |
Homo sapiens | ENSG00000173175 | adenylate cyclase 5 |
Homo sapiens | ENSG00000129467 | adenylate cyclase 4 |
Homo sapiens | ENSG00000174233 | adenylate cyclase 6 |
Homo sapiens | ENSG00000078295 | adenylate cyclase 2 (brain) |
Homo sapiens | ENSG00000155897 | adenylate cyclase 8 (brain) |
Loa Loa (eye worm) | LOAG_13197 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10493 | adenylyl cyclase 3 |
Loa Loa (eye worm) | LOAG_07072 | hypothetical protein |
Mus musculus | ENSMUSG00000021536 | adenylate cyclase 2 |
Mus musculus | ENSMUSG00000020654 | adenylate cyclase 3 |
Mus musculus | ENSMUSG00000022994 | adenylate cyclase 6 |
Mus musculus | ENSMUSG00000031659 | adenylate cyclase 7 |
Mus musculus | ENSMUSG00000022220 | adenylate cyclase 4 |
Mus musculus | 224129 | adenylate cyclase 5 |
Mus musculus | ENSMUSG00000020431 | adenylate cyclase 1 |
Mus musculus | ENSMUSG00000022376 | adenylate cyclase 8 |
Onchocerca volvulus | OVOC9457 |
|
Onchocerca volvulus | OVOC6299 | Adenylate cyclase type 2 homolog |
Onchocerca volvulus | OVOC9458 | Adenylate cyclase type 3 homolog |
Onchocerca volvulus | OVOC6298 |
|
Schmidtea mediterranea | mk4.004491.00 | Adenylate cyclase type IX, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | adenylate cyclase 6 | Compounds | References |
Rattus norvegicus | Adenylate cyclase | Compounds | References |
Rattus norvegicus | Adenylate cyclase type V | Compounds | References |
Homo sapiens | adenylate cyclase 7 | Compounds | References |
Homo sapiens | adenylate cyclase 1 (brain) | Compounds | References |
Homo sapiens | adenylate cyclase 8 (brain) | Compounds | References |
Homo sapiens | adenylate cyclase 2 (brain) | Compounds | References |
Homo sapiens | adenylate cyclase 3 | Compounds | References |
Rattus norvegicus | Adenylate cyclase type II | Compounds | References |
Homo sapiens | adenylate cyclase 5 | Compounds | References |
Homo sapiens | adenylate cyclase 4 | Compounds | References |
Bos taurus | Adenylate cyclase type I | Compounds | References |