Detailed view for LOAG_00505

Basic information

TDR Targets ID: 936910
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.497 | Length (AA): 3436 | MW (Da): 391251 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00307   Calponin homology (CH) domain
PF00435   Spectrin repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005856   cytoskeleton  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
133 246 1wyq (A) 7 118 54.00 0 1 0.661678 -1.29
315 1557 3s51 (A) 16 1268 11.00 0 1 0.235258 0.74
846 1859 4zt0 (C) 149 1220 13.00 0 0.74 0.124611 1.52
1305 1546 5j1g (A) 1004 1230 16.00 0 0.03 0.185931 -1.41
1386 1451 5wst (A) 868 931 39.00 0.1 0.16 0.726008 -3.43
1563 1763 4qmd (A) 1829 2010 21.00 0 1 -0.0470017 0.23
1758 2160 5dzz (A) 2054 2425 25.00 0.000021 1 -0.0289125 1.44
2819 2983 2n03 (A) 4419 4596 28.00 0.041 1 0.199821 0.36
2819 3014 4qmd (A) 1829 2004 30.00 0.83 1 -0.0481569 0.53
3148 3221 1lm5 (A) 2622 2726 42.00 1 1 0.148337 0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127704)

Species Accession Gene Product
Brugia malayi Bm1_47925   Growth-Arrest-Specific Protein 2 Domain containing protein
Brugia malayi Bm1_47935   VAB-10A protein
Caenorhabditis elegans CELE_ZK1151.1   Protein VAB-10, isoform G
Drosophila melanogaster Dmel_CG18076   short stop
Echinococcus granulosus EgrG_000689700   Spectrin alpha actinin
Echinococcus multilocularis EmuJ_000689700   Spectrin alpha actinin
Homo sapiens ENSG00000261150   epiplakin 1
Homo sapiens ENSG00000127603   microtubule-actin crosslinking factor 1
Homo sapiens ENSG00000096696   desmoplakin
Homo sapiens ENSG00000178209   plectin
Homo sapiens ENSG00000151914   dystonin
Loa Loa (eye worm) LOAG_00504   spectraplakin
Loa Loa (eye worm) LOAG_00505   hypothetical protein
Mus musculus ENSMUSG00000054889   desmoplakin
Mus musculus ENSMUSG00000022565   plectin
Mus musculus ENSMUSG00000028649   microtubule-actin crosslinking factor 1
Mus musculus 223650   epiplakin 1
Mus musculus 102637403   predicted gene, 34221
Mus musculus ENSMUSG00000103888   dystonin
Schistosoma japonicum Sjp_0032140   Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, putative
Schistosoma japonicum Sjp_0113880   ko:K10382 dystonin, putative
Schistosoma japonicum Sjp_0129460   expressed protein
Schistosoma japonicum Sjp_0046520   IPR001101,Plectin repeat,domain-containing
Schistosoma japonicum Sjp_0123830   expressed protein
Schistosoma japonicum Sjp_0046530   Bullous pemphigoid antigen 1, isoforms 6/7, putative
Schistosoma japonicum Sjp_0046540   Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, putative
Schistosoma mansoni Smp_168650   hypothetical protein
Schistosoma mansoni Smp_138620   hypothetical protein
Schmidtea mediterranea mk4.004116.02  
Schmidtea mediterranea mk4.007745.02  
Schmidtea mediterranea mk4.007745.01  
Schmidtea mediterranea mk4.025185.00  
Schmidtea mediterranea mk4.025185.01  
Schmidtea mediterranea mk4.003269.00   Putative bollus pemphigoid antigen
Schmidtea mediterranea mk4.021042.02  
Schmidtea mediterranea mk4.007745.03  
Schmidtea mediterranea mk4.004116.03   Short stop
Trypanosoma cruzi TcCLB.503617.20   kinetoplast DNA-associated protein, putative

Essentiality

LOAG_00505 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK1151.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK1151.1 Caenorhabditis elegans larval arrest wormbase
CELE_ZK1151.1 Caenorhabditis elegans larval lethal wormbase
CELE_ZK1151.1 Caenorhabditis elegans slow growth wormbase
CELE_ZK1151.1 Caenorhabditis elegans terminal arrest variable wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Human immunodeficiency virus type 1 group M subtype B (isolate WMJ22)(HIV-1) Protein Rev Compounds References
Homo sapiens plectin Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_00505 (Loa Loa (eye worm)), hypothetical protein
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