pI: 7.0846 |
Length (AA): 147 |
MW (Da): 16217 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
17 | 131 | 5b78 (A) | 197 | 311 | 50.00 | 0.000000000014 | 1 | 1.34701 | -0.06 |
26 | 140 | 5vdc (A) | 1 | 115 | 63.00 | 0 | 1 | 1.52401 | -0.43 |
29 | 132 | 5i3l (A) | 262 | 365 | 67.00 | 0 | 1 | 1.50638 | -0.51 |
85 | 133 | 4qf2 (A) | 1678 | 1726 | 51.00 | 0 | 1 | 0.951933 | -0.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131492)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_54295 | Zinc finger, C2H2 type family protein |
Brugia malayi | Bm1_54300 | Hypothetical C28H8.9 in chromosome III |
Caenorhabditis elegans | CELE_C28H8.9 | Protein DPFF-1, isoform B |
Drosophila melanogaster | Dmel_CG2682 | CG2682 gene product from transcript CG2682-RB |
Echinococcus granulosus | EgrG_000747700 | Zinc finger PHD finger |
Echinococcus multilocularis | EmuJ_000448200 | phd finger protein 10 |
Echinococcus multilocularis | EmuJ_000747700 | |
Homo sapiens | ENSG00000205683 | D4, zinc and double PHD fingers, family 3 |
Homo sapiens | ENSG00000133884 | D4, zinc and double PHD fingers family 2 |
Loa Loa (eye worm) | LOAG_07378 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07379 | hypothetical protein |
Mus musculus | ENSMUSG00000021221 | D4, zinc and double PHD fingers, family 3 |
Mus musculus | ENSMUSG00000024826 | D4, zinc and double PHD fingers family 2 |
Schistosoma japonicum | Sjp_0024980 | Zinc finger protein ubi-d4, putative |
Schistosoma mansoni | Smp_123390 | requim req/dpf2 |
Schmidtea mediterranea | mk4.004813.02 | Requim, req/dpf2, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.