Detailed view for LOAG_07517

Basic information

TDR Targets ID: 937966
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.4096 | Length (AA): 832 | MW (Da): 92460 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
18 582 3vyc (A) 476 1047 9.00 0 0.46 0.630387 -0.3
18 423 1hci (A) 330 741 13.00 0 1 0.485281 0.41
230 418 5vjt (A) 4 194 17.00 0.011 0.1 0.266663 -0.57
340 580 4psj (A) 32 244 30.00 0.89 0.68 0.423263 0.37

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130496)

Species Accession Gene Product
Brugia malayi Bm1_03195   adenylyl cyclase
Brugia malayi Bm1_20045   histidine kinase DhkL
Brugia malayi Bm1_00215   hypothetical protein
Candida albicans CaO19.3345   similar to S. cerevisiae YDR409W
Candida albicans CaO19.7561   same as protein encoded by Efg1p-Dependent Transcript required for morphogenesis, regulated by cell density and tyrosol
Candida albicans CaO19.10853   similar to S. cerevisiae YDR409W
Dictyostelium discoideum DDB_G0277255   hypothetical protein
Dictyostelium discoideum DDB_G0280777   BRD group protein
Dictyostelium discoideum DDB_G0277687   hypothetical protein
Dictyostelium discoideum DDB_G0286967   hypothetical protein
Dictyostelium discoideum DDB_G0289263   hypothetical protein
Dictyostelium discoideum DDB_G0268920   hypothetical protein
Dictyostelium discoideum DDB_G0289151   myb domain-containing protein
Dictyostelium discoideum DDB_G0278073   hypothetical protein
Dictyostelium discoideum DDB_G0268650   hypothetical protein
Dictyostelium discoideum DDB_G0278995   hypothetical protein
Dictyostelium discoideum DDB_G0274995   hypothetical protein
Dictyostelium discoideum DDB_G0268502   hypothetical protein
Dictyostelium discoideum DDB_G0288067   hypothetical protein
Dictyostelium discoideum DDB_G0274255   hypothetical protein
Dictyostelium discoideum DDB_G0272534   hypothetical protein
Dictyostelium discoideum DDB_G0278197   hypothetical protein
Dictyostelium discoideum DDB_G0267636   hypothetical protein
Dictyostelium discoideum DDB_G0293470   transcription factor jumonji, jmjC domain-containing protein
Dictyostelium discoideum DDB_G0274275   hypothetical protein
Dictyostelium discoideum DDB_G0275733   hypothetical protein
Dictyostelium discoideum DDB_G0279051   hypothetical protein
Dictyostelium discoideum DDB_G0279863   hypothetical protein
Dictyostelium discoideum DDB_G0276389   hypothetical protein
Dictyostelium discoideum DDB_G0286467   hypothetical protein
Dictyostelium discoideum DDB_G0267888   hypothetical protein
Dictyostelium discoideum DDB_G0285435   hypothetical protein
Dictyostelium discoideum DDB_G0277357   RmlC-like cupin family protein
Dictyostelium discoideum DDB_G0269962   hypothetical protein
Dictyostelium discoideum DDB_G0278209   hypothetical protein
Dictyostelium discoideum DDB_G0304683   hypothetical protein
Dictyostelium discoideum DDB_G0275867   hypothetical protein
Dictyostelium discoideum DDB_G0271606   hypothetical protein
Dictyostelium discoideum DDB_G0292472   hypothetical protein
Dictyostelium discoideum DDB_G0281825   Rab GTPase domain-containing protein
Dictyostelium discoideum DDB_G0278749   hypothetical protein
Dictyostelium discoideum DDB_G0285119   hypothetical protein
Dictyostelium discoideum DDB_G0284513   hypothetical protein
Dictyostelium discoideum DDB_G0275267   hypothetical protein
Dictyostelium discoideum DDB_G0268052   hypothetical protein
Dictyostelium discoideum DDB_G0279425   hypothetical protein
Dictyostelium discoideum DDB_G0268368   myb domain-containing protein
Dictyostelium discoideum DDB_G0270056   hypothetical protein
Dictyostelium discoideum DDB_G0269172   prespore-specific protein
Dictyostelium discoideum DDB_G0289321   hypothetical protein
Drosophila melanogaster Dmel_CG15740   CG15740 gene product from transcript CG15740-RB
Loa Loa (eye worm) LOAG_07517   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_07517 (Loa Loa (eye worm)), hypothetical protein
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