Detailed view for LOAG_10440

Basic information

TDR Targets ID: 937992
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.9525 | Length (AA): 90 | MW (Da): 10025 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 89 5eil (A) 25 109 29.00 0 0.94 1.36609 -0.43
3 89 1n0r (A) 26 108 28.00 0 1 1.35487 -0.58
7 63 5lea (A) 167 222 36.00 0.14 1 1.22993 -1.57
14 63 5enq (D) 93 130 50.00 0.23 0.6 0.762156 0.33
42 75 2etb (A) 291 324 29.00 0 0.97 0.744478 -0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129953)

Species Accession Gene Product
Babesia bovis BBOV_I003310   ankyrin repeat domain containing protein
Brugia malayi Bm1_46560   Ankyrin repeat
Caenorhabditis elegans CELE_F40G9.17   Protein F40G9.17
Cryptosporidium hominis Chro.70014   hypothetical protein
Cryptosporidium parvum cgd7_20   hypothetical protein
Dictyostelium discoideum DDB_G0289189   26S proteasome non-ATPase regulatory subunit 10
Echinococcus granulosus EgrG_000872400   26S proteasome non ATPase regulatory subunit 10
Entamoeba histolytica EHI_134800   ankyrin repeat protein, putative
Echinococcus multilocularis EmuJ_000872400   26S proteasome non ATPase regulatory subunit 10
Homo sapiens ENSG00000101843   proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Loa Loa (eye worm) LOAG_10440   hypothetical protein
Loa Loa (eye worm) LOAG_01436   hypothetical protein
Mus musculus ENSMUSG00000031429   proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Saccharomyces cerevisiae YGR232W   Nas6p
Schistosoma japonicum Sjp_0036030   ko:K06694 26S proteasome non-ATPase regulatory subunit 10, putative
Schistosoma japonicum Sjp_0117620   IPR002110,Ankyrin,domain-containing
Schistosoma mansoni Smp_064320.5   26S proteasome subunit
Schistosoma mansoni Smp_064320.1   26S proteasome subunit
Schmidtea mediterranea mk4.000743.07  
Schmidtea mediterranea mk4.000079.12   26S proteasome non-ATPase regulatory subunit 10
Trichomonas vaginalis TVAG_021950   ankyrin repeat-containing protein, putative
Trichomonas vaginalis TVAG_212010   ankyrin, putative

Essentiality

LOAG_10440 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F40G9.17 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_10440 (Loa Loa (eye worm)), hypothetical protein
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