pI: 8.219 |
Length (AA): 492 |
MW (Da): 53716 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
8 | 485 | 4ybq (A) | 7 | 479 | 37.00 | 0 | 1 | 1.38934 | -0.22 |
9 | 481 | 4zw9 (A) | 2 | 466 | 43.00 | 0 | 1 | 1.55918 | -1.02 |
11 | 486 | 4ybq (A) | 10 | 479 | 35.00 | 0 | 1 | 1.37328 | -0.47 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127135)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G05150 | sugar transporter ERD6-like 8 |
Arabidopsis thaliana | AT5G16150 | plastidic glucose transporter |
Brugia malayi | Bm1_35495 | Sugar transporter family protein |
Candida albicans | CaO19.2865 | almost identical to C terminus of CaP19.2425 |
Candida albicans | CaO19.2425 | C terminus is almost identical to CaP19.2865 |
Candida albicans | CaO19.10383 | almost identical to C terminus of CaP19.2425 |
Candida albicans | CaO19.9963 | C terminus is almost identical to CaP19.2865 |
Caenorhabditis elegans | CELE_H17B01.1 | Protein FGT-1, isoform A |
Drosophila melanogaster | Dmel_CG1208 | CG1208 gene product from transcript CG1208-RB |
Drosophila melanogaster | Dmel_CG43946 | Glucose transporter 1 |
Echinococcus granulosus | EgrG_000853700 | solute carrier family 2 facilitated glucose |
Echinococcus granulosus | EgrG_000853500 | solute carrier family 2 facilitated glucose |
Echinococcus granulosus | EgrG_000853600 | General substrate transporter |
Echinococcus granulosus | EgrG_000853400 | solute carrier family 2 facilitated glucose |
Echinococcus granulosus | EgrG_000972600 | solute carrier family 2 facilitated glucose |
Echinococcus multilocularis | EmuJ_000972600 | solute carrier family 2, facilitated glucose |
Echinococcus multilocularis | EmuJ_000853400 | solute carrier family 2 facilitated glucose |
Echinococcus multilocularis | EmuJ_000853600 | General substrate transporter |
Echinococcus multilocularis | EmuJ_000853700 | solute carrier family 2 facilitated glucose |
Echinococcus multilocularis | EmuJ_000853500 | solute carrier family 2 facilitated glucose |
Homo sapiens | ENSG00000181856 | solute carrier family 2 (facilitated glucose transporter), member 4 |
Homo sapiens | ENSG00000173262 | solute carrier family 2 (facilitated glucose transporter), member 14 |
Homo sapiens | ENSG00000059804 | solute carrier family 2 (facilitated glucose transporter), member 3 |
Homo sapiens | ENSG00000117394 | solute carrier family 2 (facilitated glucose transporter), member 1 |
Loa Loa (eye worm) | LOAG_09566 | sugar transporter |
Mus musculus | ENSMUSG00000003153 | solute carrier family 2 (facilitated glucose transporter), member 3 |
Mus musculus | ENSMUSG00000018566 | solute carrier family 2 (facilitated glucose transporter), member 4 |
Mus musculus | ENSMUSG00000028645 | solute carrier family 2 (facilitated glucose transporter), member 1 |
Neospora caninum | NCLIV_051560 | Glucose transporter 1A, related |
Oryza sativa | 4325804 | Os01g0133400 |
Plasmodium berghei | PBANKA_0302500 | hexose transporter |
Plasmodium falciparum | PF3D7_0204700 | hexose transporter |
Plasmodium knowlesi | PKNH_0416200 | hexose transporter, putative |
Plasmodium vivax | PVX_003665 | hexose transporter |
Plasmodium yoelii | PY00899 | putative sugar transporter |
Saccharomyces cerevisiae | YBR241C | hypothetical protein |
Schistosoma japonicum | Sjp_0132820 | Solute carrier family 2, facilitated glucose transporter member 3, putative |
Schistosoma japonicum | Sjp_0041820 | Solute carrier family 2, facilitated glucose transporter member 1, putative |
Schistosoma japonicum | Sjp_0212170 | ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative |
Schistosoma japonicum | Sjp_0219380 | IPR005828,General substrate transporter,domain-containing |
Schistosoma japonicum | Sjp_0093040 | ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative |
Schistosoma japonicum | Sjp_0305070 | Solute carrier family 2, facilitated glucose transporter member 4, putative |
Schistosoma mansoni | Smp_046790 | glucose transport protein |
Schistosoma mansoni | Smp_012440 | glucose transport protein |
Schistosoma mansoni | Smp_105410 | glucose transport protein |
Schistosoma mansoni | Smp_127200 | hypothetical protein |
Schmidtea mediterranea | mk4.003679.04 | |
Schmidtea mediterranea | mk4.003768.03 | |
Schmidtea mediterranea | mk4.003863.01 | Glucose transporter type 1 |
Schmidtea mediterranea | mk4.059399.02 | |
Schmidtea mediterranea | mk4.003679.02 | |
Schmidtea mediterranea | mk4.006187.00 | |
Schmidtea mediterranea | mk4.003768.02 | |
Schmidtea mediterranea | mk4.010027.00 | |
Schmidtea mediterranea | mk4.004966.07 | |
Schmidtea mediterranea | mk4.012121.00 | |
Schmidtea mediterranea | mk4.003998.00 | |
Schmidtea mediterranea | mk4.007746.00 | |
Schmidtea mediterranea | mk4.020573.02 | |
Schmidtea mediterranea | mk4.019915.00 | |
Schmidtea mediterranea | mk4.004966.06 | |
Schmidtea mediterranea | mk4.014339.00 | |
Schmidtea mediterranea | mk4.003863.02 | |
Toxoplasma gondii | TGME49_214320 | facilitative glucose transporter GT1 |
Trichomonas vaginalis | TVAG_244110 | conserved hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_214320 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | solute carrier family 2 (facilitated glucose transporter), member 1 | Compounds | References |
Plasmodium falciparum | hexose transporter | Compounds | References |
Homo sapiens | solute carrier family 2 (facilitated glucose transporter), member 3 | Compounds | References |
Rattus norvegicus | Solute carrier family 2, facilitated glucose transporter member 1 | Compounds | References |