Detailed view for LOAG_15422

Basic information

TDR Targets ID: 938168
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 8.2963 | Length (AA): 155 | MW (Da): 17830 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0008417   fucosyltransferase activity  
GO:0006486   protein amino acid glycosylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
35 142 2aqw (A) 183 295 28.00 0.29 0.01 0.711174 1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126881)

Species Accession Gene Product
Arabidopsis thaliana AT1G71990   alpha-(1,4)-fucosyltransferase
Brugia malayi Bm1_43965   alpha1,3-fucosyltransferase homologue
Brugia malayi Bm1_53055   Fucosyl transferase family protein
Caenorhabditis elegans CELE_K12H6.3   Protein FUT-4
Caenorhabditis elegans CELE_F59E12.13   Protein FUT-3
Caenorhabditis elegans CELE_T05A7.10   Protein FUT-5
Caenorhabditis elegans CELE_T05A7.5   Protein FUT-6
Caenorhabditis elegans CELE_K08F8.3   Protein FUT-1
Dictyostelium discoideum DDB_G0284775   hypothetical protein
Dictyostelium discoideum DDB_G0274297   hypothetical protein
Dictyostelium discoideum DDB_G0284467   hypothetical protein
Drosophila melanogaster Dmel_CG40305   CG40305 gene product from transcript CG40305-RB
Drosophila melanogaster Dmel_CG6869   CG6869 gene product from transcript CG6869-RA
Echinococcus granulosus EgrG_000169600   glycoprotein 3 alpha L fucosyltransferase
Echinococcus granulosus EgrG_000780500   Transcription initiation factor TFIID subunit
Echinococcus granulosus EgrG_002035800   glycoprotein 3 alpha L fucosyltransferase
Echinococcus granulosus EgrG_000370400   glycoprotein 3 alpha L fucosyltransferase
Echinococcus granulosus EgrG_000170800   glycoprotein 3 alpha L fucosyltransferase
Echinococcus granulosus EgrG_000370300   alpha13fucosyltransferase
Echinococcus multilocularis EmuJ_000170800   glycoprotein 3 alpha L fucosyltransferase
Echinococcus multilocularis EmuJ_000780500   Transcription initiation factor TFIID subunit
Echinococcus multilocularis EmuJ_000169600   glycoprotein 3 alpha L fucosyltransferase
Echinococcus multilocularis EmuJ_001089700   glycoprotein 3 alpha L fucosyltransferase
Echinococcus multilocularis EmuJ_000370400   glycoprotein 3 alpha L fucosyltransferase
Echinococcus multilocularis EmuJ_000398100   glycoprotein 3 alpha L fucosyltransferase
Echinococcus multilocularis EmuJ_000370300   alpha(13)fucosyltransferase
Echinococcus multilocularis EmuJ_000997900   alpha(13)fucosyltransferase
Homo sapiens ENSG00000171124   fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
Homo sapiens ENSG00000130383   fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
Homo sapiens ENSG00000172461   fucosyltransferase 9 (alpha (1,3) fucosyltransferase)
Homo sapiens ENSG00000156413   fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
Homo sapiens ENSG00000196371   fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Loa Loa (eye worm) LOAG_06811   fucosyl transferase
Loa Loa (eye worm) LOAG_14246   hypothetical protein
Loa Loa (eye worm) LOAG_15422   hypothetical protein
Loa Loa (eye worm) LOAG_00850   hypothetical protein
Mus musculus ENSMUSG00000055373   fucosyltransferase 9
Mus musculus ENSMUSG00000049307   fucosyltransferase 4
Oryza sativa 9270041   Os04g0432366
Oryza sativa 4351626   Os12g0170600
Onchocerca volvulus OVOC6248   Alpha 1,3 fucosyltransferase homolog
Schistosoma japonicum Sjp_0202180   Glycoprotein 3-alpha-L-fucosyltransferase A, putative
Schistosoma japonicum Sjp_0012850   expressed protein
Schistosoma japonicum Sjp_0304270   ko:K03663 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase [EC2.4.1.152], putative
Schistosoma japonicum Sjp_0126380   IPR001503,Glycosyl transferase, family 10,domain-containing
Schistosoma japonicum Sjp_0070210   Glycoprotein 3-alpha-L-fucosyltransferase A, putative
Schistosoma japonicum Sjp_0036210   ko:K07634 galactoside alpha-1,3-fucosyltransferase 6, putative
Schistosoma japonicum Sjp_0083880   Glycoprotein 3-alpha-L-fucosyltransferase A, putative
Schistosoma japonicum Sjp_0044100   ko:K07632 galactoside alpha-1,3-fucosyltransferase 4, putative
Schistosoma japonicum Sjp_0039260   expressed protein
Schistosoma japonicum Sjp_0012280   ko:K07635 galactoside alpha-1,3-fucosyltransferase 7, putative
Schistosoma japonicum Sjp_0012830   ko:K03126 transcription initiation factor TFIID subunit D10, putative
Schistosoma mansoni Smp_154410   alpha(13)fucosyltransferase
Schistosoma mansoni Smp_054300   alpha(13)fucosyltransferase
Schistosoma mansoni Smp_148850   alpha(13)fucosyltransferase
Schistosoma mansoni Smp_129750   alpha(13)fucosyltransferase
Schistosoma mansoni Smp_099090   alpha(13)fucosyltransferase
Schmidtea mediterranea mk4.024075.00   Glycoprotein 3-alpha-L-fucosyltransferase A
Schmidtea mediterranea mk4.004635.06  
Schmidtea mediterranea mk4.009806.03  
Schmidtea mediterranea mk4.014138.01   Glycoprotein 3-alpha-L-fucosyltransferase A
Schmidtea mediterranea mk4.012562.00   Glycoprotein 3-alpha-L-fucosyltransferase A
Schmidtea mediterranea mk4.022564.01  
Schmidtea mediterranea mk4.004009.05   Glycoprotein 3-alpha-L-fucosyltransferase A

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens fucosyltransferase 5 (alpha (1,3) fucosyltransferase) Compounds References
Homo sapiens fucosyltransferase 6 (alpha (1,3) fucosyltransferase) Compounds References
Homo sapiens fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_15422 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment