pI: 7.0998 |
Length (AA): 256 |
MW (Da): 29141 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 255 | 5te0 (A) | 35 | 275 | 30.00 | 0 | 1 | 1.20699 | 0.1 |
9 | 170 | 2vd5 (A) | 63 | 217 | 31.00 | 0.000013 | 0.94 | 0.789012 | 0.76 |
11 | 174 | 5ng0 (B) | 12 | 172 | 19.00 | 0 | 0.96 | 0.825925 | -0.22 |
12 | 251 | 2buj (A) | 15 | 257 | 33.00 | 0 | 1 | 1.2194 | 0.09 |
123 | 224 | 4d1z (A) | 103 | 192 | 44.00 | 0.000043 | 0.27 | 0.269637 | 1.14 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129834)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G08160 | serine/threonine protein kinase 3 |
Brugia malayi | Bm1_11730 | Protein kinase domain containing protein |
Candida albicans | CaO19_7164 | hypothetical protein |
Candida albicans | CaO19.7164 | potential protein kinase similar to S. cerevisiae YPL236C |
Caenorhabditis elegans | CELE_D2045.7 | Protein D2045.7 |
Dictyostelium discoideum | DDB_G0291350 | NAK family protein kinase |
Drosophila melanogaster | Dmel_CG1227 | CG1227 gene product from transcript CG1227-RA |
Homo sapiens | ENSG00000115661 | serine/threonine kinase 16 |
Loa Loa (eye worm) | LOAG_14450 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00944 | NAK/MPSK protein kinase |
Mus musculus | ENSMUSG00000026201 | serine/threonine kinase 16 |
Oryza sativa | 4346472 | Os09g0237600 |
Oryza sativa | 4346899 | Os09g0372800 |
Saccharomyces cerevisiae | YPL236C | Env7p |
Schistosoma japonicum | Sjp_0060270 | ko:K08856 serine/threonine kinase 16, putative |
Schistosoma mansoni | Smp_126460 | serine/threonine protein kinase |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | serine/threonine kinase 16 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 24.6% | 167 aa | Compounds | References |