Detailed view for LOAG_05022

Basic information

TDR Targets ID: 938219
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 4.6719 | Length (AA): 430 | MW (Da): 47927 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00018   SH3 domain
PF00790   VHS domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0006886   intracellular protein transport  

Metabolic Pathways

Endocytosis (KEGG)
Jak-STAT signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 183 2l0t (B) 8 162 44.00 0 1 0.984442 -1.37
32 171 3ldz (A) 5 142 43.00 0 1 1.00958 -2.2
229 291 2l0a (A) 10 72 67.00 0 1 0.964512 -1
239 273 1g2b (A) 9 43 37.00 0.018 0.78 0.392395 1.27

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129713)

Species Accession Gene Product
Brugia malayi Bm1_33810   Variant SH3 domain containing protein
Candida albicans CaO19.3233   similar to S. cerevisiae YHL002W
Candida albicans CaO19.10743   similar to S. cerevisiae YHL002W
Caenorhabditis elegans CELE_C34G6.7   Protein STAM-1, isoform B
Drosophila melanogaster Dmel_CG6521   Signal transducing adaptor molecule
Echinococcus granulosus EgrG_000305200   expressed protein
Echinococcus multilocularis EmuJ_000305200   expressed protein
Homo sapiens ENSG00000115145   signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Homo sapiens ENSG00000136738   signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Loa Loa (eye worm) LOAG_05022   hypothetical protein
Mus musculus ENSMUSG00000026718   signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Mus musculus ENSMUSG00000055371   signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
Saccharomyces cerevisiae YHL002W   ESCRT-0 subunit protein HSE1
Schistosoma japonicum Sjp_0069020   ko:K04705 signal transducing adaptor molecule, putative
Schistosoma mansoni Smp_126520   signal transducing adapter molecule (stam)
Schmidtea mediterranea mk4.003336.02   Signal transducing adapter molecule 1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0075 0.2576 0.2576
0.0137 0.2846 0.2741
0.0065 0.3464 0.32
0.0059 0.3 0.3006
0.0039 0.2713 0.2713
0.0048 0.3625 0.3625
0.0027 0.3179 0.3179
0.0065 0.3464 0.32
0.00394418 0.278418 0.262031
0.0029 0.4037 0.4037
0.0282 0.283 0.4202
0.0068 0.2794 0.2794
0.0048 0.281 0.281
0.0282 0.283 0.4202
0.0029 0.4037 0.4037
0.0064 0.3347 0.3362
0.0322685 0.273741 0.262341
0.0336199 0.276589 0.265254
0.0039 0.2713 0.2713
0.0027 0.3179 0.3179
0.0137 0.3036 0.3036
0.0378 0.315 0.3101
0.0061 1 1
0.00394418 0.278418 0.262031
0.0351989 0.270507 0.26116

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_05022 (Loa Loa (eye worm)), hypothetical protein
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