Detailed view for LOAG_08037

Basic information

TDR Targets ID: 938672
Loa Loa (eye worm), aspartic protease BmAsp-1
Source Database / ID:  KEGG  

pI: 5.0838 | Length (AA): 413 | MW (Da): 46715 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00026   Eukaryotic aspartyl protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0004190   aspartic-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 410 1miq (A) 92 323 21.00 0 1 1.0698 0.5
23 410 5mlg (A) 10 378 30.00 0 1 1.19167 -0.28
61 172 4od9 (A) 7 94 43.00 0 0.27 0.321986 1.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_187723)

Species Accession Gene Product
Brugia malayi Bm1_34740   aspartic protease BmAsp-1, identical
Caenorhabditis elegans CELE_Y39B6A.22   Protein ASP-15
Caenorhabditis elegans CELE_Y39B6A.23   Protein ASP-16
Loa Loa (eye worm) LOAG_08037   aspartic protease BmAsp-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Pepsinogen C 392 aa 30.8% 416 aa Compounds References
Sus scrofa Pepsin A 385 aa 29.3% 406 aa Compounds References
Bos taurus Cathepsin D 390 aa 26.9% 417 aa Compounds References
Macaca mulatta Renin 406 aa 27.3% 406 aa Compounds References
Penicillium janthinellum Penicillopepsin 323 aa 22.3% 355 aa Compounds References
Rattus norvegicus Renin 402 aa 26.5% 408 aa Compounds References
Rhizopus microsporus var. chinensis Rhizopuspepsin 393 aa 25.7% 350 aa Compounds References
Oryctolagus cuniculus Renin 280 aa 27.2% 312 aa Compounds References
Callithrix jacchus Renin 400 aa 26.8% 400 aa Compounds References
Macaca fascicularis Renin 406 aa 27.3% 406 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0106 0.5 0.5
0.0021 1 1
0.0021 1 1
0.0021 0.443 0.443
0.0021 0.4249 0.4249
0.0021 0.7491 0.7491
0.0021 1 1
0.0021 1 1
0.0021 1 1
0.0068 1 1
0.0021 1 1
0.002 0.5 0.5
0.0021 1 1
0.0021 1 1
0.0106 0.5 0.5
0.0021 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08037 (Loa Loa (eye worm)), aspartic protease BmAsp-1
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