Detailed view for LOAG_10503

Basic information

TDR Targets ID: 938967
Loa Loa (eye worm), G protein signaling regulator EGL-10

Source Database / ID:  KEGG  

pI: 7.6324 | Length (AA): 534 | MW (Da): 61988 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00610   Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
PF00615   Regulator of G protein signaling domain
PF00631   GGL domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0008277   regulation of G-protein coupled receptor protein signaling pathway  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 515 2pbi (A) 7 421 36.00 0 1 1.12887 0.43
380 513 2d9j (A) 5 138 44.00 0 1 0.928736 -1.46
382 507 1agr (E) 51 177 40.00 0 1 0.909255 -2.07
383 508 2ihd (A) 46 172 36.00 0 1 0.892755 -2.26

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130674)

Species Accession Gene Product
Brugia malayi Bm1_22680   regulator of G-protein signaling egl-10
Caenorhabditis elegans CELE_F28C1.2   Protein EGL-10, isoform C
Drosophila melanogaster Dmel_CG9108   Regulator of G-protein signaling 7
Echinococcus granulosus EgrG_000714100   regulator of G protein signaling 7
Echinococcus multilocularis EmuJ_000714100   regulator of G protein signaling 7
Homo sapiens ENSG00000182732   regulator of G-protein signaling 6
Homo sapiens ENSG00000182901   regulator of G-protein signaling 7
Loa Loa (eye worm) LOAG_10503   G protein signaling regulator EGL-10
Mus musculus ENSMUSG00000021219   regulator of G-protein signaling 6
Mus musculus ENSMUSG00000026527   regulator of G protein signaling 7
Schistosoma japonicum Sjp_0025400   Regulator of G-protein signaling 7, putative
Schistosoma mansoni Smp_138430   regulator of G protein signaling
Schmidtea mediterranea mk4.000440.08   Regulator of G-protein signaling egl-10
Schmidtea mediterranea mk4.000440.07   Regulator of G-protein signaling egl-10

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_10503 (Loa Loa (eye worm)), G protein signaling regulator EGL-10
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