Detailed view for LOAG_03116

Basic information

TDR Targets ID: 939162
Loa Loa (eye worm), cytochrome P450

Source Database / ID:  KEGG  

pI: 9.5377 | Length (AA): 503 | MW (Da): 58422 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0005506   iron ion binding  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 502 4lxj (A) 33 527 17.00 0 1 1.11655 0.12
29 467 3e6i (A) 31 458 35.00 0 1 1.28736 -0.6
29 499 4eji (A) 32 494 34.00 0 1 1.42998 -1.09
31 492 1dt6 (A) 30 480 39.00 0 1 1.32909 -0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_165082)

Species Accession Gene Product
Brugia malayi Bm1_42095   cytochrome P450
Loa Loa (eye worm) LOAG_03116   cytochrome P450

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cytochrome P450 2B4 491 aa 35.0% 477 aa Compounds References
Rattus norvegicus Cytochrome P450 2D3 500 aa 33.2% 491 aa Compounds References
Sorghum bicolor Obtusifoliol 14-alpha demethylase 492 aa 22.9% 481 aa Compounds References
Rattus norvegicus Cytochrome P450 2D2 500 aa 32.4% 463 aa Compounds References
Canis familiaris Cytochrome P450 2B11 494 aa 34.5% 449 aa Compounds References
Rattus norvegicus Cytochrome P450 2A2 492 aa 33.2% 473 aa Compounds References
Thlaspi arvense Cytochrome P450 71B1 496 aa 24.3% 485 aa Compounds References
Rattus norvegicus Cytochrome P450 2C23 494 aa 33.2% 476 aa Compounds References
Rattus norvegicus Cytochrome P450 2D18 500 aa 33.0% 470 aa Compounds References
Rattus norvegicus Cytochrome P450 2E1 493 aa 32.6% 506 aa Compounds References
Rattus norvegicus Cytochrome P450 2B1 491 aa 32.6% 423 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0004 0.5 0.5
0.0068 0.4312 0.4312
0.0111 0.3549 1
0.0004 0.5 0.5
0.0049 0.6682 0
0.0051 0.5 0.5
0.0062 0.5 0.5
0.0004 0.5 0.5
0.0346 0.2559 0.2559
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0262 0.3083 0.3083
0.0027 1 1
0.0007 0.5 0.5
0.0059 0.5 0.5
0.0004 0.5 0.5
0.0042 1 1
0.0016 1 1
0.0038 0.5 0.5
0.0075 0.3265 0.1464
0.0004 0.5 0.5
0.007 0.3303 0.3281
0.0079 0.2909 0.2909
0.0145 0.7126 0.7126
0.0388 0.2772 0.2713
0.0038 1 1
0.0004 0.5 0.5
0.015 0.2827 0.278
0.0026 0.5 0.5
0.007 1 1
0.0102 0.3061 0.3138
0.0004 0.5 0.5
0.002 1 1
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0087 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0331 0.3985 0.3985
0.0073 1 1
0.000376403 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0368 0.2796 0.2796
0.0052 0.3769 0.4125
0.0069 0.5 0.5
0.0004 0.5 0.5
0.0073 1 1
0.0033 0.5 0.5
0.0057 0.2766 0.9062
0.0103 0.6953 0.6953
0.0004 0.5 0.5
0.0084 0.3462 0.3388
0.0032 1 1
0.0173 0.3858 0.3508
0.0004 0.5 0.5
0.0217 0.8044 0.9565
0.0012 0.5 0.5
0.007 1 1
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0284 0.2726 0.2726
0.0004 0.5 0.5
0.0057 0.2766 0.9062
0.0032 0.5 0.5
0.0083 0.5 0.5
0.0092 0.467 0.467
0.004 0.5565 0
0.0361 0.2704 0.2512
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0202 0.2702 0.2702
0.0004 0.5 0.5
0.0056 0.6399 0.6946
0.0048 0.6634 0
0.0004 0.5 0.5
0.0075 1 1
0.0137 0.271 0.2774
0.0033 0.5 0.5
0.0007 0.5 0.5
0.004 1 1
0.0004 0.5 0.5
0.0103 1 1
0.0011 0.5 0.5
0.0086 0.5 0.5
0.0033 0.2605 0.2605
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0019 0.271 0.271
0.0023 0.5 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0011 0.5 0.5
0.0008 0.5 0.5
0.0051 0.5 0.5
0.0059 0.6064 0.6758
0.0012 0.5 0.5
0.0082 0.5 0.5
0.015 0.2827 0.278
0.0081 0.5 0.5
0.0015 0.5 0.5
0.0176 0.3425 0.4374
0.0162 0.2769 0.34
0.0004 0.5 0.5
0.000376403 0.5 0.5
0.0067 0.5 0.5
0.0032 1 1
0.00184047 0.269186 0.269186
0.0008 0.5 0.5
0.0065 1 1
0.0119 0.4458 0.4435
0.0053 1 1
0.0004 0.5 0.5
0.0018 1 1
0.0023 1 1
0.0388 0.2772 0.2713
0.0011 0.5 0.5
0.0023 1 1
0.0029 1 1
0.0065 0.3393 0
0.0055 0.2887 0.2887
0.0071 0.9628 1
0.00139338 1 1
0.0004 0.5 0.5
0.0156 0.4244 0.4244
0.0316 0.2652 0.2652
0.0018 0.2876 0.2876
0.0065 0.5 0.5
0.0353 0.4928 1
0.0037 0.2694 0.2694
0.0021 0.4036 0.4036
0.0133 0.2787 0.2785
0.005 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.008 0.2582 0.2582
0.0007 0.5 0.5
0.006 0.2795 0.2778
0.0289 0.2916 0.2916
0.0032 0.5 0.5
0.0034 0.337 0.337
0.0036 0.4353 0
0.0019 0.5 0.5
0.0011 1 1
0.015 0.3435 0.3435
0.0046 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0044 0.4237 0.4237
0.0049 0.293 0.293
0.0019 0.271 0.271
0.0341 0.2689 0.2682
0.033 0.3723 0.384
0.026 0.251 0.2723
0.0015 0.5 0.5
0.0042 0.3378 0.3378
0.0004 0.5 0.5
0.036 0.2841 0.2826
0.0063 0.4653 0.5094
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0018 0.5004 0.4844
0.0012 1 1
0.0058 0.5 0.5
0.0059 0.6064 0.6758
0.00777519 0.280873 0.229211
0.0036 1 1
0.0047 0.6638 0
0.0019 0.5 0.5
0.0007 0.5 0.5
0.0063 0.5 0.5
0.0047 0.6689 0
0.0018 0.5 0.5
0.0569 0.2624 0.2624
0.0004 0.5 0.5
0.0284 0.2924 0.2924
0.0316 0.2652 0.2652
0.0047 0.5 0.5
0.0018 0.3602 0.3602
0.0004 0.5 0.5
0.0081 0.5 0.5
0.0184 0.3352 0.5166
0.0055 0.5 0.5
0.0004 0.5 0.5
0.0046 0.6591 0.6342
0.0004 0.5 0.5
0.0082 0.5 0.5
0.0002 0.5 0.5
0.0004 0.5 0.5
0.0122 0.4249 0.4197
0.0018 0.5 0.5
0.0082 0.5 0.5
0.0075 0.2816 0.2795
0.0051 0.3758 0.4112
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0066 1 1
0.0033 0.3348 0
0.0042 0.5 0.5
0.0018 0.2637 0.257
0.0189 0.5524 0.5128
0.004 1 1
0.0004 0.5 0.5
0.003 0.3514 0.3514
0.0004 0.5 0.5
0.0014 0.5 0.5
0.0235 0.3192 0.3192
0.008 0.5 0.5
0.0008 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0074 1 1
0.0004 0.5 0.5
0.0326 0.2819 0.2819
0.0071 0.5 0.5
0.01 0.5 0.5
0.0015 0.5 0.5
0.0007 0.5 0.5
0.00505219 0.5 0.5
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0025 0.5 0.5
0.0004 0.5 0.5
0.0228 0.2829 0.2829
0.0004 0.5 0.5
0.0068 0.5 0.5
0.0004 0.5 0.5
0.0068 1 1
0.0011 0.5 0.5
0.0052 0.2829 0.2665
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.034 0.2765 0.2765
0.0103 0.4147 0.4168
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0004 1 1
0.0016 0.5 0.5
0.0048 1 1
0.0027 0.5 0.5
0.0067 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.003 0.3271 0.3271
0.0004 0.5 0.5
0.0059 0.6064 0.6758
0.0167 0.2978 0.2978
0.0063 0.3886 0.3886
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0119 0.5 0.5
0.0004 0.5 0.5
0.0323 0.2823 0.2823
0.0268 0.2982 0.2982
0.0045 0.5 0.5
0.0166 0.2888 0.2888
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0127 0.5337 0.5337
0.0166 0.5366 0.5366
0.0008 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0217 0.2742 0.2734
0.0004 0.5 0.5
0.0119 0.4458 0.4435
0.0059 0.6064 0.6758
0.00213675 0.269186 0.269186
0.0046 0.2608 0.5806
0.0004 0.5 0.5
0.0022 0.5 0.5
0.0059 0.5 0.5
0.0121 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0071 0.5 0.5
0.0124 0.2696 0.2696
0.0336 0.2847 0.2847
0.0146 0.6654 0.6654
0.0569 0.2624 0.2624
0.004 1 1
0.0004 0.5 0.5
0.0028 0.2972 0.2956
0.0036 0.5 0.5
0.000218985 0.5 0.5
0.0286 1 1
0.0004 1 1
0.0011 0.5 0.5
0.0011 0.5 0.5
0.0184 0.3508 0.3508
0.0185 0.2528 0.2528
0.0004 0.5 0.5
0.0022 0.5 0.5
0.0353 0.4928 1
0.0173 0.3457 0.3457
0.0004 0.5 0.5
0.0052 0.3825 0.4186
0.0029 0.5 0.5
0.0015 0.5 0.5
0.0203 0.2689 0.2582
0.0004 0.5 0.5
0.0019 0.2756 0.3071
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0235 0.2812 0.2812
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0047 0.6638 0
0.004 1 1
0.0038 0.525 0.7781
0.0193 0.311 0.311
0.0004 0.5 0.5
0.0072 1 1
0.0084 1 0.5
0.0004 0.5 0.5
0.0118 0.3485 0.3485
0.0023 0.5 0.5
0.0054 1 1
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0093 0.3481 0.3481
0.0007 0.5 0.5
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0368 0.2796 0.2796
0.0022 0.3789 0.3789
0.0012 0.5 0.5
0.0076 1 1
0.0078 1 1
0.0099 0.7122 0.7122
0.0032 0.5 0.5
0.002 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0011 0.5 0.5
0.0018 0.5 0.5
0.0037 0.4283 0.4283
0.0078 0.3003 0.3003
0.0004 0.5 0.5
0.0018 0.5004 0.4844
0.0015 0.5 0.5
0.0331 0.3985 0.3985
0.0046 0.5 0.5
0.0093 0.5 0.5
0.0048 0.6597 0
0.0066 0.5 0.5
0.008 1 1
0.0004 0.5 0.5
0.0063 0.2543 0.2497
0.0011 0.5 0.5
0.0072 1 1
0.0004 0.5 0.5
0.0026 0.5 0.5
0.0008 0.5 0.5
0.0091 0.2951 0.2951
0.0062 0.2905 0.29
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.00109509 1 1
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0083 1 1
0.0174 0.2937 0.2937
0.0004 0.5 0.5
0.0004 0.5 0.5
0.00451124 0.405669 0.405669
0.0007 0.5 0.5
0.0114 1 1
0.0094 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0019 0.5 0.5
0.0015 0.5 0.5
0.0016 1 1
0.0021 0.5 0.5
0.0004 0.5 0.5
0.0008 1 1
0.00213675 0.269186 0.269186
0.0004 0.5 0.5
0.00213675 0.269186 0.269186
0.0004 0.5 0.5
0.0106 0.2751 0.2751
0.0025 0.5 0.5
0.0004 0.5 0.5
0.0084 0.5 0.5
0.0011 0.5 0.5
0.0019 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0104 0.5 0.5
0.000218985 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0197 0.6846 0.795
0.0092 1 1
0.0267 0.27 0.27
0.0056 0.3577 0.3577
0.0094 0.2887 0.2871
0.0008 0.5 0.5
0.0146 0.6069 0.6069
0.0026 0.5 0.5
0.0027 1 1
0.0046 0.6591 0.6342
0.0004 0.5 0.5
0.0083 0.6735 0.6735
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0011 1 1
0.0284 0.2924 0.2924
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0033 0.5 0.5
0.0051 0.4977 0.4977
0.0038 0.5102 0.3326
0.0246 0.2667 0.2667
0.0028 0.5 0.5
0.0004 0.5 0.5
0.025 0.2789 0.2789
0.0108 0.2733 0.2733
0.005 0.3622 0.3964
0.0004 0.5 0.5
0.0157 0.3541 0.3541
0.0063 0.5 0.5
0.0028 0.5 0.5
0.0291 0.2657 0.2657
0.005 0.2698 0.2698
0.008 0.2556 0.2556
0.005 1 1
0.0054 0.5 0.5
0.0012 0.5 0.5
0.007 0.5713 0.5
0.0003 0.5 0.5
0.033 0.3723 0.384
0.026 0.251 0.2723
0.0011 1 1
0.0008 0.3317 0.3317
0.0008 0.3317 0.3317
0.0073 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0029 0.36 0.767
0.0004 0.5 0.5
0.0045 0.5 0.5
0.007 0.5 0.5
0.0087 1 1
0.004 1 1
0.0044 0.6112 0
0.0012 0.5 0.5
0.0216 0.2583 0.2246
0.0443 0.3118 0.3114
0.0036 0.5 0.5
0.0004 0.5 0.5
0.0249 0.3082 0.3071
0.0004 0.5 0.5
0.0069 1 1
0.0003 0.5 0.5
0.0164 0.3784 0.2701
0.0099 0.7062 0.7062
0.0007 1 1
0.0022 0.3489 0.3489
0.0071 0.3514 0.3514
0.0069 0.2847 0.2847
0.0065 1 1
0.0035 0.4422 1
0.0323 0.3673 0.3673
0.0133 0.256 0.2561
0.0071 0.2928 0.2914
0.0007 1 1
0.0023 0.9674 0.9674
0.033 0.3723 0.384
0.0324 0.2701 0.2701
0.0012 0.5 0.5
0.0004 1 1
0.0114 1 1
0.000396385 0.5 0.5
0.0077 0.5 0.5
0.0044 0.2627 0.2627
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.00213675 0.269186 0.269186

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_03116 (Loa Loa (eye worm)), cytochrome P450
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