Detailed view for LOAG_09863

Basic information

TDR Targets ID: 939380
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 10.1981 | Length (AA): 221 | MW (Da): 24897 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005544   calcium-dependent phospholipid binding  
GO:0006887   exocytosis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 221 2r83 (A) 163 376 20.00 0.0000000011 0.77 1.1592 0.53
105 221 2q3x (A) 1449 1562 28.00 0 0.99 0.858712 -0.73
107 221 1v27 (A) 1 113 25.00 0 0.78 0.834662 -0.45
107 221 1dqv (A) 295 399 34.00 0 1 0.894662 -0.52
118 205 3b7y (A) 109 193 42.00 0.0013 0.94 0.65959 0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130110)

Species Accession Gene Product
Arabidopsis thaliana AT1G05500   synaptotagmin-5
Arabidopsis thaliana AT5G11100   synaptotagmin-4
Brugia malayi Bm1_28640   C2 domain containing protein
Caenorhabditis elegans CELE_T12A2.15   Protein ESYT-2, isoform B
Drosophila melanogaster Dmel_CG6643   Extended synaptotagmin-like protein 2 ortholog (H. sapiens)
Echinococcus granulosus EgrG_000810900   extended synaptotagmin 2
Echinococcus multilocularis EmuJ_000810900   extended synaptotagmin 2
Homo sapiens ENSG00000117868   extended synaptotagmin-like protein 2
Homo sapiens ENSG00000158220   extended synaptotagmin-like protein 3
Loa Loa (eye worm) LOAG_03951   C2 domain-containing protein
Loa Loa (eye worm) LOAG_09863   hypothetical protein
Mus musculus ENSMUSG00000037681   extended synaptotagmin-like protein 3
Mus musculus ENSMUSG00000021171   extended synaptotagmin-like protein 2
Oryza sativa 4345217   Os08g0300200
Schistosoma japonicum Sjp_0300400   Extended synaptotagmin-2, putative
Schistosoma mansoni Smp_050640   glut4 vesicle protein-related
Schistosoma mansoni Smp_050630   synaptotagmin
Schmidtea mediterranea mk4.000010.01   Glut4 vesicle protein-related

Essentiality

LOAG_09863 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T12A2.15 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.005 0.2612 0.9039
0.0109 0.4866 1
0.0072 0.2639 0.9142
0.0107 0.5 0.5
0.0057 0.3491 0.3491
0.0058 0.5 0.5
0.0071 0.2549 1
0.0121 1 1
0.0018 0.5 0.5
0.0125 0.3893 0.3893

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_09863 (Loa Loa (eye worm)), hypothetical protein
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