Detailed view for LOAG_06892

Basic information

TDR Targets ID: 939486
Loa Loa (eye worm), protein-tyrosine phosphatase 1
Source Database / ID:  KEGG  

pI: 6.6412 | Length (AA): 421 | MW (Da): 47756 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00102   Protein-tyrosine phosphatase
PF00595   PDZ domain (Also known as DHR or GLGF)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016791   phosphoric monoester hydrolase activity  
GO:0005515   protein binding  
GO:0004725   protein tyrosine phosphatase activity  
GO:0016311   dephosphorylation  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 110 2cs5 (A) 11 114 62.00 0 1 1.01938 -0.86
13 99 2r4h (A) 6 86 26.00 0 1 0.632851 -1.75
37 82 1ihj (A) 48 92 33.00 0.28 0.88 0.511864 -0.13
44 397 6cmp (B) 101 514 33.00 0 1 1.08546 -0.03
128 411 4ri5 (A) 0 908 57.00 0 1 1.49018 -1.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131438)

Species Accession Gene Product
Brugia malayi Bm1_30020   Protein-tyrosine phosphatase 1
Caenorhabditis elegans CELE_C48D5.2a   Protein PTP-1, isoform B
Caenorhabditis elegans CELE_C48D5.2   Protein PTP-1, isoform A
Drosophila melanogaster Dmel_CG1228   CG1228 gene product from transcript CG1228-RH
Echinococcus granulosus EgrG_000912800   tyrosine protein phosphatase non receptor type
Echinococcus multilocularis EmuJ_000912800   tyrosine protein phosphatase non receptor type
Homo sapiens ENSG00000088179   protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Homo sapiens ENSG00000070159   protein tyrosine phosphatase, non-receptor type 3
Loa Loa (eye worm) LOAG_06892   protein-tyrosine phosphatase 1
Mus musculus ENSMUSG00000038764   protein tyrosine phosphatase, non-receptor type 3
Mus musculus ENSMUSG00000026384   protein tyrosine phosphatase, non-receptor type 4
Schistosoma mansoni Smp_132370   protein-tyrosine phosphatase non-receptor type nt5
Schmidtea mediterranea mk4.004419.02   Putative 4.1 G protein
Schmidtea mediterranea mk4.024215.00   Tyrosine-protein phosphatase 1
Schmidtea mediterranea mk4.004968.00   Tyrosine-protein phosphatase 1
Schmidtea mediterranea mk4.022788.00  
Schmidtea mediterranea mk4.011495.00  
Schmidtea mediterranea mk4.028102.00  
Schmidtea mediterranea mk4.017124.01   Tyrosine-protein phosphatase 1
Schmidtea mediterranea mk4.006795.00   Putative 4.1 G protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) Compounds References
Homo sapiens protein tyrosine phosphatase, non-receptor type 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0011 1 0.5
0.0011 1 1
0.0011 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_06892 (Loa Loa (eye worm)), protein-tyrosine phosphatase 1
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