pI: 7.8734 |
Length (AA): 485 |
MW (Da): 54281 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
53 | 133 | 1wmh (A) | 16 | 96 | 22.00 | 0 | 0.77 | 0.41101 | -0.83 |
69 | 469 | 3uzt (A) | 34 | 439 | 23.00 | 0 | 1 | 0.965804 | 0.78 |
72 | 471 | 3v5w (A) | 37 | 441 | 25.00 | 0 | 1 | 1.01674 | 0.4 |
226 | 479 | 6e2m (B) | 686 | 939 | 40.00 | 0 | 1 | 0.897911 | -0.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128416)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G09000 | mitogen-activated protein kinase kinase kinase ANP1 |
Arabidopsis thaliana | AT3G06030 | mitogen-activated protein kinase kinase kinase 3 |
Arabidopsis thaliana | AT1G54960 | NPK1-related protein kinase 2 |
Brugia malayi | Bm1_11350 | Protein kinase domain containing protein |
Candida albicans | CaO19.8464 | likely MAPKKK similar to S. cerevisiae STE11 (YLR362W) MAPKKK of the pheromone response pathway |
Candida albicans | CaO19.844 | likely MAPKKK similar to S. cerevisiae STE11 (YLR362W) MAPKKK of the pheromone response pathway |
Dictyostelium discoideum | DDB_G0283265 | F-box-containing protein |
Echinococcus granulosus | EgrG_000389600 | mitogen activated protein kinase kinase kinase |
Echinococcus multilocularis | EmuJ_000389600 | mitogen activated protein kinase kinase kinase |
Homo sapiens | ENSG00000169967 | mitogen-activated protein kinase kinase kinase 2 |
Homo sapiens | ENSG00000198909 | mitogen-activated protein kinase kinase kinase 3 |
Homo sapiens | ENSG00000176601 | mitogen-activated protein kinase kinase kinase 19 |
Loa Loa (eye worm) | LOAG_05805 | STE/STE11/MEKK2 protein kinase |
Mus musculus | ENSMUSG00000024383 | mitogen-activated protein kinase kinase kinase 2 |
Mus musculus | ENSMUSG00000020700 | mitogen-activated protein kinase kinase kinase 3 |
Mus musculus | ENSMUSG00000051590 | mitogen-activated protein kinase kinase kinase 19 |
Oryza sativa | 4345595 | Os08g0421800 |
Oryza sativa | 4346940 | Os09g0383300 |
Onchocerca volvulus | OVOC11755 |
|
Saccharomyces cerevisiae | YLR362W | Ste11p |
Schistosoma japonicum | Sjp_0018650 | ko:K04416 mitogen-activated protein kinase kinase kinase 1, putative |
Schistosoma mansoni | Smp_050380 | protein kinase |
Schmidtea mediterranea | mk4.012560.04 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.003911.08 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.000848.07 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.004421.00 | |
Schmidtea mediterranea | mk4.001978.02 | Serine/threonine-protein kinase PAK mbt |
Schmidtea mediterranea | mk4.009148.02 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.000265.07 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.000517.02 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.005767.00 | |
Schmidtea mediterranea | mk4.001734.00 | |
Schmidtea mediterranea | mk4.000652.08 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.017614.00 | |
Schmidtea mediterranea | mk4.000165.17 | |
Schmidtea mediterranea | mk4.000049.07 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.001445.01 | Mitogen-activated protein kinase kinase kinase 19 |
Schmidtea mediterranea | mk4.000848.08 | |
Schmidtea mediterranea | mk4.002610.01 | |
Schmidtea mediterranea | mk4.002795.01 | |
Schmidtea mediterranea | mk4.001800.02 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.006618.00 | |
Schmidtea mediterranea | mk4.001330.04 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.000239.01 | Serine/threonine-protein kinase PAK mbt |
Schmidtea mediterranea | mk4.001605.00 | Serine/threonine-protein kinase flr-4 |
Schmidtea mediterranea | mk4.006212.02 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 3 | Compounds | References |
Homo sapiens | mitogen-activated protein kinase kinase kinase 19 | Compounds | References |
Homo sapiens | mitogen-activated protein kinase kinase kinase 2 | Compounds | References |