Detailed view for LOAG_15462

Basic information

TDR Targets ID: 939909
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.4646 | Length (AA): 130 | MW (Da): 14829 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00209   Sodium:neurotransmitter symporter family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005328   neurotransmitter:sodium symporter activity  
GO:0006836   neurotransmitter transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 130 4xp4 (A) 115 263 56.00 0 0.69 1.2426 1.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128364)

Species Accession Gene Product
Brugia malayi Bm1_23195   Sodium:neurotransmitter symporter family protein
Caenorhabditis elegans CELE_Y54E10BR.7   Protein MOD-5
Caenorhabditis elegans CELE_T23G5.5   Protein DAT-1
Drosophila melanogaster Dmel_CG8380   Dopamine transporter
Drosophila melanogaster Dmel_CG4545   Serotonin transporter
Echinococcus granulosus EgrG_000391300   serotonin transporter
Echinococcus multilocularis EmuJ_000391300   serotonin transporter
Homo sapiens ENSG00000108576   solute carrier family 6 (neurotransmitter transporter), member 4
Homo sapiens ENSG00000142319   solute carrier family 6 (neurotransmitter transporter), member 3
Homo sapiens ENSG00000103546   solute carrier family 6 (neurotransmitter transporter), member 2
Loa Loa (eye worm) LOAG_14913   hypothetical protein
Loa Loa (eye worm) LOAG_15462   hypothetical protein
Loa Loa (eye worm) LOAG_13270   norepinephrine transporter
Loa Loa (eye worm) LOAG_15262   solute carrier family 6 member 4
Loa Loa (eye worm) LOAG_07270   hypothetical protein
Loa Loa (eye worm) LOAG_14180   serotonin transporter b
Mus musculus ENSMUSG00000055368   solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Mus musculus ENSMUSG00000020838   solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Mus musculus ENSMUSG00000021609   solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Onchocerca volvulus OVOC1812  
Schistosoma japonicum Sjp_0013560   Sodium-dependent dopamine transporter, putative
Schistosoma japonicum Sjp_0011420   ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative
Schistosoma japonicum Sjp_0011430   Sodium-dependent noradrenaline transporter, putative
Schistosoma japonicum Sjp_0013570   Sodium-dependent dopamine transporter, putative
Schistosoma japonicum Sjp_0110630   Sodium-dependent dopamine transporter, putative
Schistosoma japonicum Sjp_0121560   IPR000175,Sodium:neurotransmitter symporter,domain-containing
Schistosoma japonicum Sjp_0021470   Sodium-dependent dopamine transporter, putative
Schistosoma japonicum Sjp_0304220   Sodium-dependent dopamine transporter, putative
Schistosoma japonicum Sjp_0120420   Sodium-dependent dopamine transporter, putative
Schistosoma mansoni Smp_156320   norepinephrine/norepinephrine transporter
Schistosoma mansoni Smp_193800   sodium/chloride dependent transporter
Schmidtea mediterranea mk4.028772.00   Sodium-dependent serotonin transporter
Schmidtea mediterranea mk4.003695.00   Transporter
Schmidtea mediterranea mk4.004541.02  
Schmidtea mediterranea mk4.002395.11   Transporter
Schmidtea mediterranea mk4.003307.01  
Schmidtea mediterranea mk4.007017.01   Sodium-dependent serotonin transporter
Schmidtea mediterranea mk4.053977.00  
Schmidtea mediterranea mk4.000714.06  
Schmidtea mediterranea mk4.018756.02   Sodium-dependent serotonin transporter
Schmidtea mediterranea mk4.005059.00   Putative norepinephrine/norepinephrine transporter
Schmidtea mediterranea mk4.039158.00  
Schmidtea mediterranea mk4.005059.01  
Schmidtea mediterranea mk4.000843.12  
Schmidtea mediterranea mk4.002950.00   Transporter
Treponema pallidum TP0023   sodium- and chloride- dependent transporter

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Dopamine transporter Compounds References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Compounds References
Rattus norvegicus Norepinephrine transporter Compounds References
Macaca mulatta Serotonin transporter Compounds References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Compounds References
Rattus norvegicus Transporter Compounds References
Macaca fascicularis Dopamine transporter Compounds References
Mus musculus solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Compounds References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Compounds References
Macaca mulatta Transporter Compounds References
Mus musculus solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 Compounds References
Bos taurus Dopamine transporter Compounds References
Mus musculus solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Compounds References
Rattus norvegicus Serotonin transporter Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0635 0.3233 1
0.0249 0.2933 0.3336
0.3832 0.2704 0.2868
0.0235 0.2591 0.6684
0.194 0.478 1
0.034 0.8817 1
0.0292 1 1
0.0182 0.5 0.5
0.2935 0.5834 1
0.0177 0.5 0.5
0.0474 0.4476 1
0.0186832 0.5 0.5
0.2604 0.6095 1
0.0394 0.356 0.3897
0.0489 1 1
0.2689 1 1
0.1035 0.648 1
1.5747 0.7424 0.7424
0.0292 0.8767 1
0.0967 0.3384 0.3384
0.7524 1 1
0.1858 0.3682 1
0.0852515 1 1
0.1423 1 1
0.5723 0.4598 0.5305
0.0411 1 1
0.4609 1 1
0.1079 1 1
0.1293 0.3702 1
0.0973 1 1
0.1744 0.3091 1
0.0423 0.4065 1
0.0292 0.5 0.5
0.1244 0.3675 1
0.0449 0.3065 0.3064
0.0292 0.5 0.5
0.0219 0.264 0.3136
0.322 0.669 0.669
0.0365 0.7378 1
0.3425 0.4469 0.4469
0.1531 0.4429 0.8154
0.0292 0.5138 0.722
9.3933 0.296 1
0.0523 1 1
0.2787 1 1
0.1004 1 1
0.3997 0.5857 1
0.0146 0.5 0.5
0.0245 0.3105 0.5091
0.0561 0.5671 1
0.1083 0.7749 0.7749
0.1284 0.3171 0.3171
0.0235 0.2533 0.3136
0.092 0.6031 1
0.117 0.646 0.7269
0.0991 0.3032 0.6203
0.2382 1 1
0.057 0.7128 1
0.0071 0.2861 0.2861
0.1856 1 1
0.4164 1 1
0.4209 0.9965 0.9965
0.4235 1 1
0.0392 0.5289 0.6033
0.0266 1 1
0.2921 1 1
0.0537 1 1
0.1305 1 1
0.1367 1 1
0.6787 0.3791 1
0.2811 1 1
0.0617 0.3617 0.4815
0.0146 0.5 0.5
0.1774 1 1
0.0444 0.3163 0.3163
0.0292 0.5 0.5
0.0292 0.5 0.5
0.1632 0.3316 1
0.0662 0.7264 1
0.3325 0.5026 0.5025
0.0587 0.2583 0.784
0.1751 1 1
0.024 0.5 0.5
0.2856 1 1
0.2099 1 1
0.0151 0.5 0.5
0.0448 0.5105 1
0.0292 1 1
0.3195 0.5 0.5
0.237 1 1
0.0109 1 1
0.0474 0.3468 0.6827
0.0252 0.4851 1
0.1443 1 1
0.0524 0.5 0.5
0.1856 1 1
0.1987 1 1
0.0292 0.5 0.5
0.2137 0.4908 1
0.0182 0.5 0.5
6.958 0.5867 1
0.4458 0.829 1
0.0984 1 1
0.0184 0.255 0.3203
0.0219 0.8084 0.883
0.0292 0.3011 0.3431
0.8182 1 1
1.5747 0.7424 0.7424
0.0417 0.2637 0.2637
0.0182 1 1
0.0584 1 1
0.0824 0.5631 1
1.1247 1 1
0.8833 1 1
0.048 0.2645 0.2851
0.0224 0.4122 0.4122
0.1558 0.9071 1
0.0264 0.5 0.5
0.1669 0.4936 0.7008
2.6113 1 1
0.2036 1 1
0.0096 0.2742 0.4368
0.0485 0.3403 0.3581
0.0442 0.2611 0.3907
0.8795 0.9727 1
0.1093 0.5 0.5
0.1208 1 1
0.531 1 1
0.0423 0.3538 0.8537
0.16 0.9311 1
0.4619 1 1
0.0285 1 1
0.2146 1 1
1.178 1 1
0.0258 0.2782 0.756
0.3321 1 1
0.0146 0.5 0.5
0.1293 0.2809 0.9931
0.3824 0.3725 0.5859
0.0322 0.6448 0.6697
0.0164 1 1
0.0146 0.5 0.5
0.0486 0.7325 0.7325
0.2032 1 1
0.1462 0.5 0.5
0.2733 0.6519 1
0.2182 0.6414 1
0.0109 0.3074 0.3074
0.1242 1 1
0.0292 0.3811 1
0.332 1 1
0.1475 0.3316 0.3289
0.0253 1 1
0.4572 0.474 0.4739
0.0584 0.3536 0.9557
0.0365 0.5 0.5
0.02 1 1
0.095 0.5 0.5
0.0243 0.2509 0.3184
4.7006 0.2766 1
0.0566 0.5 0.5
0.1557 1 1
0.441 0.3152 1
0.1669 0.4936 0.7008
0.1119 1 1
0.0292 0.5 0.5
0.0406 0.7909 1
0.1027 1 1
0.024 0.524 1
0.1929 0.3934 1
0.015 0.6059 0.6868
0.0235 0.6611 0.8765
0.088 0.5826 1
0.0224 0.2605 0.5099
0.0846 0.5 0.5
0.0547 1 1
0.2272 0.4514 0.5066
0.929 1 1
0.0237 0.262 0.2661
0.1669 0.4936 0.7008
0.0073 0.5 0.5
0.0799 1 1
0.2292 0.5 0.5
0.5815 0.6056 0.7368
0.037 1 1
0.254 1 1
0.2161 1 1
0.0723 0.3041 0.3908
0.1246 0.8104 1
0.0764 0.5 0.5
0.2358 1 1
0.423 1 1
0.2332 0.5734 1
0.1108 0.5027 0.5027
0.0482 0.2816 1
0.243 1 1
0.0292 0.3623 1
0.0263 0.4713 0.4713
3.179 1 1
0.112 0.5671 1
0.6544 1 1
0.463 1 1
0.1137 1 1
0.226 1 1
0.0292 0.3409 1
0.022 0.2508 0.8013
0.0228 1 1
0.3132 0.3094 0.3619
0.0073 0.4036 0.4036
0.1277 0.5298 0.9662
0.0292 0.5 0.5
0.0182 0.5 0.5
0.0822 1 1
0.1615 0.6489 1
0.0338 1 1
0.0183 0.5 0.5
0.0318 0.6415 0.7349
0.21218 0.334774 0.344988
0.0789 1 1
0.0272 0.6517 1
0.0711 0.2806 0.608
0.1136 0.5 0.5
0.1394 0.3684 0.3684
0.1845 1 1
0.0147 0.605 0.695
0.0236 0.6346 0.6346
0.0292 0.5 0.5
0.0672 1 1
0.0738 0.9788 0.9788
0.0292 0.4134 1
0.0292 0.2852 0.6701
0.5043 1 1
0.011 1 1
0.0419 0.5 0.5
0.0235 0.284 0.9867
0.0073 0.5 0.5
1.5747 0.7424 0.7424
0.6925 1 1
2.2998 0.6589 1
0.3092 1 1
0.4219 1 1
0.3674 1 1
0.0292 0.3082 0.8337
0.0365 1 1
0.0234 1 1
0.315 1 1
0.0688 0.2717 1
0.0325 0.3245 0.5459
0.0148 1 1
0.0292 0.2881 1
0.1162 0.3808 0.3808
0.0073 0.5 0.5
1.7494 1 1
0.0492 0.5667 1
0.4717 0.7102 0.7102
0.0592 0.7034 1
0.0275 0.4096 0.4096
0.1119 1 1
0.2653 0.6321 0.6321
0.3827 0.3277 0.3292
0.0236 1 1
0.1234 0.648 0.6475
0.1021 0.5 0.5
0.0109 1 1
0.0728 0.547 1
0.0264 0.4318 0.5124
0.084 1 1
0.1316 1 1
0.0284 0.7614 0.7614
0.0292 0.3237 1
0.2206 1 1
0.0396 0.4231 0.4231
0.0294 0.3556 1
0.1816 1 1
0.1412 0.7665 0
0.0292 0.8629 0.9745
0.1979 1 1
0.1293 1 1
0.2093 0.9077 1
0.036 0.2865 0.5614
0.1151 0.5258 1
0.0257 0.4142 0.4142
0.0264 0.5 0.5
2.2261 1 1
0.0147 0.3667 0.3667
0.2653 1 1
0.3832 0.2704 0.2868
0.3981 0.5249 0.5249
0.3796 1 1
0.0871 1 1
0.0292 0.3116 0.9439
0.0305 0.4623 0.3359
0.4237 0.3122 0.5024
0.1968 0.8983 1
0.1301 0.2956 0.3135
0.044 0.3467 0.3456
0.1822 1 1
0.0738 0.5 0.5
0.0268 0.291 1
0.0748 0.2503 0.6643
0.1093 0.2583 1
0.1443 0.9019 0.9315
0.16 1 1
0.6363 1 1
0.0883 0.2572 1
0.0109 1 1
0.0755 0.5 0.5
0.0603 0.2559 0.8937
0.334 1 1
0.1753 0.6529 0.6529
0.0292 1 1
0.052 1 1
0.075 0.2622 0.2622
0.3946 0.5 0.5
0.0295 0.3655 0.9717
0.5387 1 1
0.2294 1 1
0.0153 0.5 0.5
0.2471 0.2943 0.5469
0.0109 0.2712 0.3417
0.1456 1 1
0.2191 1 1
0.0292 0.794 1
0.0787 0.5 0.5
0.0292 0.5 0.5
0.0479 0.2811 1
0.6876 1 1
0.0292 1 1
0.1594 0.9584 1
0.0295223 0.258537 0.258537
0.0147 0.5 0.5
0.1838 0.5 0.5
0.0147 0.5 0.5
0.1142 0.3905 0.3905
0.0318 0.7729 0.7729
0.0488 0.255 0.5
0.7574 1 1
0.0135 0.5 0.5
0.0249 0.2585 0.4195
0.0774 1 1
0.2176 0.5014 0.5014
0.2131 0.4738 1
0.1272 0.5 0.5
0.0788 0.8258 1
0.174059 0.432027 0.651318
0.132 0.6252 0.8175
0.2825 0.4945 1
0.0073 0.5 0.5
0.1514 0.2565 1
0.153 0.545 1
0.0292 1 1
0.136 0.3508 1
0.3876 1 1
0.0152 1 1
0.0292 1 1
0.0119 0.5812 0.5
0.1899 0.8398 0.8398
0.0686 0.6786 1
0.0334 1 1
0.1314 1 1
0.3841 0.574 0.574
0.0182 0.2847 1
0.1043 1 1
0.0182 0.5 0.5
0.0292 0.6632 1
0.1003 1 1
0.0237 0.285 0.4147
0.0776 1 1
0.3933 1 1
0.0292 1 1
0.4876 0.8355 0.8355
0.1826 0.3662 0.3662
0.098 1 1
0.0492 0.5052 1
0.5467 1 1
0.6577 0.7863 1
0.1404 1 1
0.0886 0.3292 1
0.1314 0.9987 0.9987
0.0182 0.5 0.5
0.0292 0.3168 0.4617
0.2946 1 1
0.0521 0.5096 1
0.1534 0.4614 1
0.229 0.2698 1
0.2401 1 1
0.3004 1 1
0.0634 0.4589 0.7934
0.0071 1 1
0.2426 0.534 1
0.7294 1 1
0.0257 0.2981 1
0.0292 0.5 0.5
0.0477 1 1
0.3067 0.3628 0.7844
0.091 0.5 0.5
0.0269 0.5872 0.5872
0.0356 0.6082 0.6082
0.0242 0.6339 0.8522
0.1008 0.6083 1
0.0284 0.565 0.565
0.0258 0.2779 1
0.056164 1 1
0.2335 0.5 0.5
0.0327 0.3232 1
0.0235 0.3684 0.401
0.0065 0.2734 0.2734
0.5815 0.6056 0.7368
0.1511 0.442 1
0.0132 0.2712 0
0.1068 1 1
0.2309 0.3578 1
0.4835 0.385 0.5281
0.3314 0.3985 0.8182
0.0039 0.3016 0.3016
0.0745 1 1
0.1858 0.8639 1
0.0584 0.4199 1
0.1671 0.8342 0.9532
0.1032 0.5 0.5
0.2054 1 1
0.0125 0.2938 0.3693
0.0146 0.5 0.5
0.0276 0.4572 1
0.5469 0.936 0.936
0.6194 0.787 0.7932
0.0088 0.4819 0.9081
0.0169 0.2904 0.7926
0.0365 0.2791 0.5797
0.3067 0.3628 0.7844
0.0567 0.4161 0.8384
0.2058 1 1
0.0246 1 1
0.4778 1 1
0.0268 0.5455 0.6156
0.0573 0.5 0.5
0.0304 0.6115 0.6115
0.0242 0.3478 0.3478
0.1785 1 1
0.2323 0.5 0.5
0.0318 0.2995 0.4575
0.0109 0.359 0.5
0.1466 0.7756 0.9789
0.0491 0.6054 1
0.3844 1 1
0.0486 0.8105 0.8105
0.0092 0.2881 0.2881
0.2873 0.3987 1
0.1541 0.2614 1
0.2301 0.2868 1
0.0617 0.3617 0.4815
0.1434 1 1
0.0292 0.5 0.5
0.0292 1 1
0.0182 0.3912 0.5395
0.4914 1 1
0.0292 0.6337 0.7079
0.0109 1 1
0.0365 0.6155 1
0.2729 0.2508 0
0.0257 0.2581 0.4085
0.0264 0.3069 1
0.4758 0.4944 0.4944
0.0169 0.5 0.5
0.0239 0.5 0.5
0.0669 0.5501 0.5501
0.0146 0.5 0.5
0.0387 1 1
0.1164 1 1
0.0281 0.2794 0.2794
0.0292 0.3817 0.4503
0.1274 0.5 0.5
0.0957 0.3313 0.3309
0.2343 1 1
0.0525 0.7044 1
0.4362 0.9361 1
1.1309 0.5471 1
0.033 0.4512 0.4502
0.0234 0.6159 0.9574
0.0424 0.6139 0.81
0.1842 0.3369 0.6008
0.518 1 1
0.0423 0.3626 0.3626
0.1078 1 1
0.1723 0.5408 0.5408
0.0328 0.5 0.5
0.0282 1 1
0.0292 0.3329 0.9017
0.0965 0.2995 1
5.1757 0.4115 1
0.1596 0.3766 0.3742
0.0476 1 1
0.1669 0.4936 0.7008
0.0373 0.5 0.5
0.025 1 1
0.0091 0.2647 0.2647
0.1243 0.754 1
0.6791 1 1
0.0248 0.3386 1
0.130453 1 1
0.2244 1 1
0.0852 0.5 0.5
0.0528 0.6567 1
0.0243555 0.277164 0.351739
0.2001 1 1
0.0477 1 1
0.0365 0.5 0.5
0.6525 1 1
0.2539 0.5972 1
0.9408 0.3184 1
0.0292 0.8839 1
0.155 0.4823 0.4823
0.0182 0.5 0.5
0.006 1 1
0.044 0.3467 0.3456
0.0522 0.259 0.259
0.2804 1 1
0.1299 0.28 1
0.0542 1 1
0.0385 0.682 0.6816
0.3452 1 1
0.0562 0.5687 1
0.1132 0.3605 0.3605
0.0552 0.6844 1
0.024 0.2577 0.3145
0.0682 0.6932 1
0.0561 0.2538 0.3737
0.0729 0.4867 0.4863
10.8938 0.3665 1
0.0185 0.4274 0.4274
0.0511 0.5 0.5
0.0182 0.5 0.5
0.0091 1 1
0.3446 0.2717 0.2717
0.0249 0.2803 1
0.0276 0.2952 0.3738
0.0206 0.2691 0.3474
0.0629 1 1
0.0575 0.3084 0.3079
0.1663 1 1
0.0292 0.332 0.4524
0.0395 0.8427 0.9146
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