Detailed view for LOAG_03492

Basic information

TDR Targets ID: 940652
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 5.035 | Length (AA): 119 | MW (Da): 13843 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04898   Glutamate synthase central domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0015930   glutamate synthase activity  
GO:0003824   catalytic activity  
GO:0055114   oxidation reduction  
GO:0006807   nitrogen compound metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126892)

Species Accession Gene Product
Arabidopsis thaliana AT5G53460   glutamate synthase 1 [NADH]
Arabidopsis thaliana AT2G41220   ferredoxin-dependent glutamate synthase 2
Arabidopsis thaliana AT5G04140   ferredoxin-dependent glutamate synthase 1
Brugia malayi Bm1_40910   glutamate synthase
Candida albicans CaO19.13636   likely glutamate synthase similar to S. cerevisiae GLT1 (YDL171C)
Candida albicans CaO19.6257   likely glutamate synthase similar to S. cerevisiae GLT1 (YDL171C)
Caenorhabditis elegans CELE_W07E11.1   Protein W07E11.1, isoform B
Drosophila melanogaster Dmel_CG9674   CG9674 gene product from transcript CG9674-RD
Escherichia coli b2468   putative oxidoreductase, FeS binding subunit/NAD/FAD-binding subunit
Escherichia coli b3212   glutamate synthase, large subunit
Escherichia coli b2887   putative oxidoreductase, Fe-S subunit/nucleotide-binding subunit
Escherichia coli b3213   glutamate synthase, 4Fe-4S protein, small subunit
Echinococcus granulosus EgrG_000644000   glutamate synthase
Entamoeba histolytica EHI_110520   glutamate synthase beta subunit, putative
Entamoeba histolytica EHI_045340   glutamate synthase beta subunit, putative
Echinococcus multilocularis EmuJ_000644000   glutamate synthase
Giardia lamblia GL50803_7195   Glutamate synthase
Loa Loa (eye worm) LOAG_03492   hypothetical protein
Mycobacterium leprae ML0062   Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate
Mycobacterium leprae ML0061   Probable ferredoxin-dependent glutamate synthase (large subunit) GltB (L-glutamate synthase) (L-glutamate synthetase) (NADH-glut
Mycobacterium tuberculosis Rv3859c   Probable ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB (L-glutamate synthase) (L-glutamate synthetase) (N
Mycobacterium tuberculosis Rv3858c   Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate
Mycobacterium ulcerans MUL_5036   glutamate synthase subunit beta
Mycobacterium ulcerans MUL_5037   ferredoxin-dependent glutamate synthase large subunit GltB
Oryza sativa 9268275   Os07g0676200
Oryza sativa 4339561   Os05g0555600
Oryza sativa 4344164   Os07g0658400
Oryza sativa 4324398   Os01g0681900
Onchocerca volvulus OVOC5367   Putative glutamate synthase
Plasmodium berghei PBANKA_1009500   NAD(P)H-dependent glutamate synthase, putative
Plasmodium falciparum PF3D7_1435300   NAD(P)H-dependent glutamate synthase, putative
Plasmodium knowlesi PKNH_0421900   NAD(P)H-dependent glutamate synthase, putative
Plasmodium vivax PVX_084770   NAD(P)H-dependent glutamate synthase, putative
Plasmodium yoelii PY03719   NAD(P)H-dependent glutamate synthase-related
Saccharomyces cerevisiae YDL171C   glutamate synthase (NADH)
Schistosoma japonicum Sjp_0087440   Putative glutamate synthase [NADPH], putative
Schistosoma japonicum Sjp_0067700   ko:K00264 glutamate synthase (NADPH) [EC1.4.1.13], putative
Schistosoma mansoni Smp_128380.2   glutamate synthase
Schistosoma mansoni Smp_128380.1   glutamate synthase
Schistosoma mansoni Smp_128380.3   glutamate synthase
Schmidtea mediterranea mk4.005136.00   Putative glutamate synthase
Schmidtea mediterranea mk4.009183.01  
Schmidtea mediterranea mk4.009183.00  
Schmidtea mediterranea mk4.000669.03   Putative glutamate synthase
Treponema pallidum TP0735   oxidoreductase

Essentiality

LOAG_03492 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3926 Mycobacterium tuberculosis essential nmpdr
mtu3925 Mycobacterium tuberculosis essential nmpdr
b2468 Escherichia coli non-essential goodall
b2887 Escherichia coli non-essential goodall
b3212 Escherichia coli non-essential goodall
b3213 Escherichia coli non-essential goodall
CELE_W07E11.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_W07E11.1 Caenorhabditis elegans larval arrest wormbase
CELE_W07E11.1 Caenorhabditis elegans slow growth wormbase
PBANKA_1009500 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LOAG_03492 (Loa Loa (eye worm)), hypothetical protein
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