Detailed view for LOAG_07032

Basic information

TDR Targets ID: 940707
Loa Loa (eye worm), immunoglobulin I-set domain-containing protein
Source Database / ID:  KEGG  

pI: 8.6636 | Length (AA): 912 | MW (Da): 100699 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00041   Fibronectin type III domain
PF07679   Immunoglobulin I-set domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 100 5noi (A) 412 507 47.00 0 1 0.635049 -0.57
7 431 4pbx (A) 135 497 28.00 0 1 0.439409 1.35
36 98 3dmk (B) 615 676 31.00 0 0.75 0.370079 -0.16
118 220 5fm5 (M) 510 612 25.00 0 0.97 0.565939 -1.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128686)

Species Accession Gene Product
Brugia malayi Bm1_06225   Immunoglobulin I-set domain containing protein
Brugia malayi Bm1_06230   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_ZK377.2   Protein SAX-3, isoform A
Drosophila melanogaster Dmel_CG5481   leak
Drosophila melanogaster Dmel_CG13521   roundabout
Drosophila melanogaster Dmel_CG5423   CG5423 gene product from transcript CG5423-RB
Echinococcus granulosus EgrG_000805500   roundabout 2
Echinococcus granulosus EgrG_000748500   roundabout 2
Echinococcus granulosus EgrG_000992700   roundabout 2
Echinococcus multilocularis EmuJ_000805500   roundabout 2
Echinococcus multilocularis EmuJ_000992700   roundabout 2
Echinococcus multilocularis EmuJ_000748500   roundabout 2
Homo sapiens ENSG00000154134   roundabout, axon guidance receptor, homolog 3 (Drosophila)
Homo sapiens ENSG00000185008   roundabout, axon guidance receptor, homolog 2 (Drosophila)
Homo sapiens ENSG00000169855   roundabout, axon guidance receptor, homolog 1 (Drosophila)
Loa Loa (eye worm) LOAG_09203   immunoglobulin I-set domain-containing protein
Loa Loa (eye worm) LOAG_07032   immunoglobulin I-set domain-containing protein
Mus musculus ENSMUSG00000022883   roundabout homolog 1 (Drosophila)
Mus musculus ENSMUSG00000052516   roundabout homolog 2 (Drosophila)
Mus musculus ENSMUSG00000032128   roundabout homolog 3 (Drosophila)
Onchocerca volvulus OVOC5391  
Schistosoma japonicum Sjp_0012540   expressed protein
Schistosoma japonicum Sjp_0024780   Roundabout homolog 2 precursor, putative
Schistosoma japonicum Sjp_0012550   Roundabout homolog 2 precursor, putative
Schistosoma japonicum Sjp_0118600   expressed protein
Schistosoma japonicum Sjp_0055180   ko:K06754 roundabout, axon guidance receptor 2, putative
Schistosoma japonicum Sjp_0103280   Roundabout homolog 2 precursor, putative
Schistosoma mansoni Smp_173100   roundabout
Schistosoma mansoni Smp_024660   cell adhesion molecule
Schmidtea mediterranea mk4.015944.00  
Schmidtea mediterranea mk4.006497.00   RoboA
Schmidtea mediterranea mk4.007418.00  
Schmidtea mediterranea mk4.019809.00  
Schmidtea mediterranea mk4.000335.02  
Schmidtea mediterranea mk4.013350.00  
Schmidtea mediterranea mk4.019809.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0116 0.2785 0.2785
0.0106 0.3726 0.3726
0.0403 0.706 1
0.0348 0.3967 0.6187
0.0104 0.8804 1
0.0084 0.4625 1
0.0203 0.2854 0.4375
0.0461 0.2819 0.999
0.0146 0.4001 0.565
0.0086 0.3597 1
0.0092 0.3268 0.472
0.0351 0.6072 1
0.0255 0.706 1
0.017 0.2614 1
0.013 0.8813 0.968
0.018 0.3131 0.3131
0.0177 0.2559 0.3647
0.0084 0.6788 1
0.0083 1 1
0.0336 0.3462 1
0.045 0.3044 0.3071
0.0164 0.7647 0.7789
0.0178 0.5983 0.5
0.0305 0.5153 0.6743
0.0009 0.5 0.5
0.0156 0.6042 1
0.0212 0.4381 0.5803
0.045 0.3044 0.3071
0.0471 0.341 1
0.0132 0.2972 0.4456
0.008 0.4641 0.4641
0.0085 0.4509 0.5086
0.022 0.257 0.5242
0.012 0.7362 0.9962
0.045 0.3044 0.3071
0.0461 0.2819 0.999
0.0089 0.4623 0.4623
0.0475 0.706 1
0.0008 1 1
0.0251 0.7407 1
0.0093 0.3031 0.3031
0.0038 0.4237 0.4237
0.0414 0.6115 1
0.0334 0.4633 0.6876
0.0088 1 1
0.0088 1 1
0.0378 0.586 1
0.0047 0.445 0.445
0.0176 0.3962 0.525
0.0184 0.706 1
0.0209 0.4772 0.64
0.0078 0.2971 0.2971
0.0255 0.706 1
0.012 0.3366 0.3358
0.0034 0.2581 0
0.0266 0.2855 1
0.0374 0.7576 1
0.0116 0.6967 0.9164
0.0338 0.7566 1
0.0006 1 1
0.0348 0.3967 0.6187
0.037 0.706 1
0.0084 0.6788 1
0.0329 0.5062 0.661
0.0216 0.706 1
0.00855091 0.284971 0.227311
0.0154 0.5295 0.5414
0.0271 0.3613 1
0.0461 0.2819 0.999
0.0348 0.3967 0.6187
0.0322 0.4001 0.565
0.0155 0.3568 1
0.0071 0.8198 0.8198
0.0111 0.334 0.3848
0.0152 0.2836 0.2813
0.0156 0.6042 1
0.0193 0.3374 0.3369
0.045 0.3044 0.3071
0.0343 0.706 1
0.0042 0.415 0.4661
0.0378 0.586 1
0.0008 1 1
0.0329 0.4001 0.565
0.0301 0.2854 0.4375
0.0488 0.3798 1
0.0236 0.3002 0.4552
0.0312 0.5397 1
0.0223 0.4639 0
0.0374 0.7576 1
0.0223 0.4639 0
0.0129 0.3276 0.323
0.0251 0.7407 1
0.0177 0.292 0.41
0.0095 0.4151 1
0.012 0.7362 0.9962
0.043 0.5151 1
0.0334 0.4633 0.6876
0.0461 0.2819 0.999
0.0305 0.4857 0.6478
0.0348 0.3967 0.6187
0.0209 0.4772 0.64
0.045 0.3044 0.3071
0.045 0.3044 0.3071
0.0074 0.2516 0.2516
0.022 0.257 0.5242
0.0089 0.442 0.3487
0.0313 0.5953 1
0.0348 0.3967 0.6187
0.0347 0.7058 0.8826
0.0178 0.5983 0.5
0.02 0.7068 1
0.0008 1 1
0.014 0.4544 0.4544
0.0326 0.5076 0.6676
0.0133 0.3628 0.3564
0.0114 0.6153 1
0.0212 0.4381 0.5803
0.0272 0.706 1
0.0272 0.4658 0.6294
0.0343 0.706 1
0.0414 0.6115 1
0.0189 0.4064 0.5376
0.0448 0.7636 1
0.00855091 0.284971 0.227311
0.0106 0.4418 0.5909
0.0006 1 1
0.045 0.3044 0.3071
0.0089 0.442 0.3487
0.0006 1 1
0.0204 0.2615 0.2948
0.0471 0.341 1
0.00855091 0.284971 0.227311
0.045 0.3044 0.3071
0.0016 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LOAG_07032 (Loa Loa (eye worm)), immunoglobulin I-set domain-containing protein
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