Detailed view for LOAG_05368

Basic information

TDR Targets ID: 941276
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.1222 | Length (AA): 536 | MW (Da): 58895 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF12053   N-terminal of Par3 and HAL proteins

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
34 73 4i6p (A) 44 81 50.00 0.092 0.94 0.458027 1.49
295 505 3gsl (A) 72 250 27.00 0.027 1 0.483057 0.29
307 356 1uju (A) 40 85 35.00 0.27 0.86 0.453684 -0.16
419 506 2v90 (A) 250 336 24.00 0 1 0.598679 -1.57

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131608)

Species Accession Gene Product
Brugia malayi Bm1_41135   Abnormal embryonic partitioning of cytoplasm protein 3
Caenorhabditis elegans CELE_F54E7.3   Protein PAR-3, isoform B
Drosophila melanogaster Dmel_CG5055   bazooka
Echinococcus granulosus EgrG_000833800   partitioning defective 3
Echinococcus granulosus EgrG_000262700   Partitioning defective 3 protein B
Echinococcus multilocularis EmuJ_001026800   partitioning defective 3
Echinococcus multilocularis EmuJ_000833800   partitioning defective 3
Homo sapiens ENSG00000116117   par-3 family cell polarity regulator beta
Homo sapiens ENSG00000148498   par-3 family cell polarity regulator
Loa Loa (eye worm) LOAG_05368   hypothetical protein
Loa Loa (eye worm) LOAG_05369   hypothetical protein
Mus musculus ENSMUSG00000025812   par-3 family cell polarity regulator
Mus musculus ENSMUSG00000052062   par-3 family cell polarity regulator beta
Schmidtea mediterranea mk4.001269.00   Cell polarity protein

Essentiality

LOAG_05368 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F54E7.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_F54E7.3 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_05368 (Loa Loa (eye worm)), hypothetical protein
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