Detailed view for LOAG_04778

Basic information

TDR Targets ID: 941339
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.4052 | Length (AA): 434 | MW (Da): 50274 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00566   Rab-GTPase-TBC domain
PF00581   Rhodanese-like domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 280 3qyb (A) 875 1162 22.00 0 1 0.852949 -0.04
90 278 3qye (A) 848 1038 30.00 0.000000019 0.99 0.717884 0.14
326 425 3g5j (A) 2 126 24.00 0 1 0.390115 -1.06
340 431 3tp9 (A) 388 470 18.00 0.0000021 0.59 0.377782 -0.41
340 433 1c25 (A) 380 482 28.00 0.69 0.2 0.31999 0.44
383 430 3aay (A) 76 123 23.00 0.63 0.39 0.287399 0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131839)

Species Accession Gene Product
Babesia bovis BBOV_IV009470   hypothetical protein
Brugia malayi Bm1_38100   Rhodanese-like domain containing protein
Brugia malayi Bm1_38095   Protein kinase domain containing protein
Caenorhabditis elegans CELE_C33F10.2   Protein TBCK-1
Dictyostelium discoideum DDB_G0267760   RabGAP/TBC domain-containing protein
Drosophila melanogaster Dmel_CG4041   CG4041 gene product from transcript CG4041-RB
Echinococcus granulosus EgrG_000625900   TBC domain containing protein kinase
Entamoeba histolytica EHI_038840   Rab GTPase activating protein, putative
Echinococcus multilocularis EmuJ_000625900   TBC domain containing protein kinase
Homo sapiens ENSG00000145348   TBC1 domain containing kinase
Loa Loa (eye worm) LOAG_05467   TBCK protein kinase
Loa Loa (eye worm) LOAG_04778   hypothetical protein
Loa Loa (eye worm) LOAG_04777   hypothetical protein
Mus musculus ENSMUSG00000028030   TBC1 domain containing kinase
Neospora caninum NCLIV_066220   TBC domain-containing kinase (incomplete catalytic triad), putative
Schistosoma japonicum Sjp_0300020   TBC domain-containing protein kinase-like protein, putative
Schistosoma mansoni Smp_139020   protein kinase
Schmidtea mediterranea mk4.008518.02  
Schmidtea mediterranea mk4.008518.01   Protein kinase
Schmidtea mediterranea mk4.018187.00   Protein kinase
Schmidtea mediterranea mk4.008590.02  
Toxoplasma gondii TGME49_250680   TBC domain-containing kinase (incomplete catalytic triad)

Essentiality

LOAG_04778 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_250680 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0005 0.3625 0.3625

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_04778 (Loa Loa (eye worm)), hypothetical protein
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