Detailed view for LOAG_08477

Basic information

TDR Targets ID: 941374
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.2546 | Length (AA): 699 | MW (Da): 79355 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05450   Nicastrin

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016485   protein processing  

Metabolic Pathways

Notch signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 644 4r12 (A) 33 603 18.00 0 1 0.909149 0.99
21 645 4r12 (A) 40 604 21.00 0 1 0.974034 0.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131095)

Species Accession Gene Product
Arabidopsis thaliana AT3G52640   Zn-dependent exopeptidases superfamily protein
Brugia malayi Bm1_35240   hypothetical protein
Brugia malayi Bm1_07315   hypothetical protein
Caenorhabditis elegans CELE_ZC434.6   Protein APH-2, isoform B
Dictyostelium discoideum DDB_G0287801   gamma-secretase subunit
Drosophila melanogaster Dmel_CG7012   nicastrin
Echinococcus granulosus EgrG_000143200   Nicastrin
Echinococcus multilocularis EmuJ_000141400   Nicastrin
Echinococcus multilocularis EmuJ_000143200   Nicastrin
Homo sapiens ENSG00000162736   nicastrin
Loa Loa (eye worm) LOAG_08477   hypothetical protein
Mus musculus ENSMUSG00000003458   nicastrin
Oryza sativa 4330658   Os02g0736500
Schistosoma japonicum Sjp_0060820   ko:K06171 nicastrin, putative
Schistosoma mansoni Smp_167240   hypothetical protein
Schmidtea mediterranea mk4.000362.04  
Schmidtea mediterranea mk4.000362.11  
Schmidtea mediterranea mk4.002707.01  
Schmidtea mediterranea mk4.010567.00  
Schmidtea mediterranea mk4.001134.01  
Schmidtea mediterranea mk4.000362.06  
Trichomonas vaginalis TVAG_267320   Nicastrin precursor, putative
Trichomonas vaginalis TVAG_387630   Nicastrin precursor, putative

Essentiality

LOAG_08477 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZC434.6 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens nicastrin Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0206 0.3776 0.3776
0.0121 0.3043 0.1629
0.0121 0.3043 0.1629
0.0097 0.3043 0.1708
0.0121 0.3043 0.1629
0.0121 0.3043 0.1629
0.0121 0.3043 0.1629
0.0121 0.3043 0.1629
0.0121 0.3043 0.1629
0.0105 0.3043 0.1629
0.0121 0.3043 0.1629
0.0097 0.3043 0.1629
0.0112 0.3043 0.1629
0.0121 0.3043 0.1629
0.0121 0.3043 0.1629
0.0121 0.3043 0.1629
0.011 0.3043 0.1629
0.0112 0.3043 0.1629
0.0121 0.3043 0.1629
0.0121 0.3043 0.1629

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_08477 (Loa Loa (eye worm)), hypothetical protein
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